Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases

Magdaleno‐Tapial, Jorge; Valenzuela‐Oñate, Cristian; Weth, M.M. Giacaman-von der; Ferrer-Guillén, Blanca; Martínez‐Doménech, Álvaro; Martínez, Marta García-Legaz; Salvador, José María Ortiz; Subiabre-Ferrer, Daniela; Hernández-Bel, P.

doi:10.1016/j.adengl.2018.11.011

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…From a treatment standpoint, there is limited information on the effect of antibiotics on HI in the genital tract. Antimicrobial susceptibility testing of HI strains from the urogenital tract suggest some strains may be resistant to azithromycin and tetracyclines, antibiotics typically used to treat urethritis [33,34]. Longitudinal studies examining the association between HI and NGU with careful collection of sexual behavior data are needed to further understand acquisition, transmission, and treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

Urethral Microbiota in Men: Association of Haemophilus influenzae and Mycoplasma penetrans With Nongonococcal Urethritis

Srinivasan

Chambers

Tapia

et al. 2020

Clinical Infectious Diseases

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Background Nongonococcal urethritis (NGU) is a common syndrome with no known etiology in up to 50% of cases. We estimated associations between urethral bacteria and NGU in men who have sex with men (MSM) and men who have sex with women (MSW). Methods Urine was collected from NGU cases (129 MSM; 121 MSW) and controls (70 MSM; 114 MSW) attending a Seattle STD clinic. Cases had ≥5 polymorphonuclear leukocytes on Gram stain plus symptoms or discharge; controls had <5 PMNs, no symptoms, no discharge. NGU was considered idiopathic when Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, adenovirus, and herpes simplex virus were absent. The urethral microbiota was characterized using 16S rRNA gene sequencing. Compositional lasso analysis was conducted to identify associations between bacterial taxa and NGU, and to select bacteria for targeted quantitative PCR (qPCR). Results Among NGU cases, 45.2% were idiopathic. Based on compositional lasso analysis, we selected Haemophilus influenzae (HI) and Mycoplasma penetrans (MP) for targeted qPCR. Compared to 182 men without NGU, the 249 men with NGU were more likely to have HI (14% vs. 2%) and MP (21% vs. 1%) (both p≤0.001). In stratified analyses, detection of HI was associated with NGU among MSM (12% vs. 3%, p=0.036) and MSW (17% vs. 1%, p<0.001), but MP was associated with NGU only among MSM (13% vs. 1%, p=0.004). Associations were stronger in men with idiopathic NGU. Conclusions HI and MP are potential causes of male urethritis. MP was more often detected among MSM than MSW with urethritis.

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Section: Discussionmentioning

confidence: 99%

Urethral Microbiota in Men: Association of Haemophilus influenzae and Mycoplasma penetrans With Nongonococcal Urethritis

Srinivasan

Chambers

Tapia

et al. 2020

Clinical Infectious Diseases

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“…Other bacterial pathogens have been implicated as potential causes of clinical urethritis, either in clustered case series or as sporadic cases such as Haemophilus influenzae and Haemophilus parainfluenzae (719)(720)(721)(722)(723). Haemophilus was identified in 12.6% of cases among 413 men (mostly MSM reporting insertive oral sex) ( 724), and high rates of azithromycin resistance (39.5%) were identified among Haemophilus urethritis patients (725). Individual case reports have linked NGU to multiple bacterial species, including Corynebacterium propinquum (726), Kurthia gibsonii (727), Corynebacterium glucuronolyticum (728,729), Corynebacterium striatrium (730), Aerococcus urinae (731), and Neisseria elongata (732).…”

Section: Etiologymentioning

confidence: 99%

“…M. genitalium is estimated to account for 10%-25% of cases (696,697,701,703,704,706,733,743), and T. vaginalis for 1%-8% of cases depending on population and location (703,706,708,710,712). Other etiologies include different bacteria, such as Haemophilus species (724,725), N. meningitidis (713,716), HSV (706,717), and adenovirus (744). However, even when extensive testing is performed, no pathogens are identified in approximately half of cases (701,733).…”

Section: Nongonococcal Urethritismentioning

confidence: 99%

Sexually Transmitted Infections Treatment Guidelines, 2021

Workowski¹,

Bachmann²,

Chan³

et al. 2021

MMWR Recomm. Rep.

1,726

2,621

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These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019. The information in this report updates the 2015 guidelines. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4) management of Mycoplasma genitalium; 5) human papillomavirus vaccine recommendations and counseling messages; 6) expanded risk factors for syphilis testing among pregnant women; 7) one-time testing for hepatitis C infection; 8) evaluation of men who have sex with men after sexual assault; and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. Physicians and other health care providers can use these guidelines to assist in prevention and treatment of STIs. BOX 1. The Five P's approach for health care providers obtaining sexual histories: partners, practices, protection from sexually transmitted infections, past history of sexually transmitted infections, and pregnancy intention Additional information about external condoms is available at https://www.cdc.gov/condomeffectiveness. Internal CondomsCondoms for internal vaginal use, also known as female condoms, are available worldwide (e.g., the FC2 Female Condom, Reddy condom, Cupid female condom, and Woman's condom) (31,32). Use of internal condoms can provide protection from acquisition and transmission of STIs, although data are limited. Internal condoms are more costly compared with external condoms; however, they offer the advantage of being controlled by the receptive partner as an STI and HIV prevention method, and the newer versions might be acceptable to all persons. Although the internal condom also has been used during receptive anal intercourse, efficacy associated with this practice remains unknown (33). Additional information about the internal condom is available at http://www.ashasexualhealth. org/pdfs/Male_and_Female_Condoms.pdf. Cervical DiaphragmsIn observational studies, diaphragm use has been demonstrated to protect against cervical gonorrhea, chlamydia, and trichomoniasis (34). However, a trial examining the effect of a diaphragm plus lubricant on HIV acquisition among women in Africa reported no additional protective effect when compared with the use of male condoms alone. Likewise, no difference by study arm in the rate of acquisition of chlamydia, gonorrhea, or herpes occurred (35,36). Diaphragms should not be relied on as the sole source of protection against HIV and other STIs.

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“…pittmaniae , and H . sputorum have been reported to be the etiological agent of nongonococcal urethritis, of which the most common one was identified as Haemophilus parainfluenzae ( 7 , 27 , 29 , 30 ). As the first isolation of H .…”

Section: Discussionmentioning

confidence: 99%

Comparative Genomic Analysis Reveals Genetic Diversity and Pathogenic Potential of Haemophilus seminalis and Emended Description of Haemophilus seminalis

et al. 2023

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As a versatile opportunistic pathogen, the accurate identification of Haemophilus species is a challenge in clinical practice. In this study, we characterized the phenotypic and genotypic features of four H. seminalis strains that were isolated from human sputum specimens and propose the “ H . intermedius ” and hemin (X-factor)-independent H. haemolyticus isolates as belonging to H. seminalis .

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Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases

Cited by 4 publications

References 7 publications

Urethral Microbiota in Men: Association of Haemophilus influenzae and Mycoplasma penetrans With Nongonococcal Urethritis

Urethral Microbiota in Men: Association of Haemophilus influenzae and Mycoplasma penetrans With Nongonococcal Urethritis

Sexually Transmitted Infections Treatment Guidelines, 2021

Comparative Genomic Analysis Reveals Genetic Diversity and Pathogenic Potential of Haemophilus seminalis and Emended Description of Haemophilus seminalis

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