Haemorheological parameters of umbilical cord blood of Nigerian newborns: correlations with maternal parameters

Dapper, DV; Didia, BC

doi:10.4314/wajm.v25i3.28283

Cited by 16 publications

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“…The present study showed significant positive correlation between maternal and fetal hemoglobin concentrations like Dapper DV et al [ 12 ] in Nigeria, McElroy PD et al [ 13 ] in Kenya, and Alizadeh L et al [ 14 ] in Iran. No significant correlation was observed between maternal and fetal white cell count and MCHC [ 12 – 14 ]. A positive linear Pearson correlation was observed between mean hemoglobin and PCV of cord blood and maternal blood.…”

Section: Discussionsupporting

confidence: 60%

Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study

Timilsina

Karki

Gautam

et al. 2018

BMC Pregnancy Childbirth

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BackgroundComplete blood count is one of the routinely advised blood investigation during pregnancy. It is also utilized as a diagnostic tool for neonatal anemia, sepsis and determining hemostatic status of the newborn. The present study aims at estimating the complete blood count of maternal and umbilical cord blood at the time of delivery and to establish its correlation.MethodThis cross sectional study included 114 mothers and their healthy neonates born through normal vaginal delivery. Complete blood count of umbilical cord blood and maternal blood was estimated using automatic hematology analyzer.ResultsThe mean maternal and neonatal hemoglobin concentration was 11.14 ± 1.39 g/dL and 16.34 ± 2.01 g/dL respectively. A significant positive correlation was found between maternal and fetal hemoglobin concentration (p < 0.001 and Pearson R = 0.496). The correlation between maternal and fetal WBC, RBC and Platelet count was not statistically significant. A significant positive correlation was found between maternal and fetal MCV and MCH while PCV showed a non-significant positive correlation.ConclusionThere was moderately positive correlation between maternal and fetal hemoglobin, MCV and MCH. The cord blood hemoglobin was lower in babies born to anemic mothers. The decrease in hemoglobin followed the severity of anemia, however, the correlation did not exist in anemic mothers. It suggested that fetal hematological parameters are not reflective of maternal hemogram.

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Section: Discussionsupporting

confidence: 60%

Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study

Timilsina

Karki

Gautam

et al. 2018

BMC Pregnancy Childbirth

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“…[21][22][23] The importance of estimation of alkali resistant hemoglobin cannot be over emphasized in a resource poor country like India which also has the dubious distinction of having a prevalence of thalassemia. 24,25 While majority of the hemoglobin in the fetus is alkali resistant, the proportion rapidly decreases in the first year of life. Literature search failed to yield any recent studies to measure alkali resistant hemoglobin estimates in India.…”

Section: Discussionmentioning

confidence: 99%

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

2016

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Background: The importance of complete hemogram along with the hematological indices in the diagnosis of neonatal health cannot be overemphasized. There is a severe paucity of relevant data regarding neonatal hematological profile in relation to gestational age and maternal diseases in this part of the country. With this perspective, the authors intended to do a pilot study to analyse the haematological profile of neonates of different gestational ages and different maternal diseases born in a teriary care hospital in Eastern India.Methods: This is a cross sectional study design based on cord blood sample of newborns and their mothers recruited from those admitted in the gynae and obstetric department in IPGME&R. The umbilical cord blood was collected from the newborn babies and then examined for different haematological parameters. The data obtained was statistically analysed.Results: While there has been a sequential rise of fetal red cell count, hemoglobin and the total white cell count neutrophils with gestational age, the mean corpuscular cell volume decreased. All these values were comprised to varying degrees in maternal diseases except for nucleated rell blood cells which conspicuously increased in neonates of diabetic mothers.Conclusions: In this study, a small attempt was made to assess the haematological profile (including alkali resistant hemoglobin) of the newborns in relation to gestational age and maternal diseases in the population attending a tertiary care hospital in Eastern India.

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“…The majority of studies were cross-sectional: 54 studies [21À74], 9 were prospective cohort studies [75À83], and two were retrospective cohort studies [84,85]. 24 studies were conducted in Asia [21À23, 32,35À37,39,40,42,49,50, 53,54,57,58,65,66,70,75,76,78,80,83], 18 in Europe [26,28,30,41,43,45,46,48,51,55,56,61,63,68,69,71,79], 8 in North America [44,52,72,73,81,82,85,86], 7 in Africa [24,27,29,31,38,47,59], 6 in South America [25,34,64,67,74,84], and 2 were conducted in Australia and Oceania. [33,60] Thirty-four studies were conducted in malaria-endemic countries [21-25,31,32,34À38,41,42,47À49,52,53,55,57À60,64À67,70,72, 74,76,78,84].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

A systematic review and meta-analysis of the correlation between maternal and neonatal iron status and haematologic indices

Sanni

Chambers

et al. 2020

EClinicalMedicine

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Background Iron deficiency (ID) is the leading single-nutrient deficiency in the world. Anaemia is a common outcome of ID that affects half of pregnancies worldwide with serious consequences for child development. Whether haematologic indices and biomarkers of iron status in pregnant women correlate with those of their neonates is unclear. This systematic review evaluated studies comparing haematologic and iron status indices in pregnant women and their newborns/neonates. Methods We searched MEDLINE, EMBASE, CINAHL, and Web of Science from database inception until March 2020 for primary studies comparing haematologic and iron status indices between women and their newborns up to 48 h after birth. We summarized the results descriptively and calculated pooled correlation coefficients in mothers and newborns/neonates using the Schmidt-Hunter method. The protocol was registered at PROSPERO International Prospective Register of Systematic Reviews (Registration number: CRD42018093094). Findings Sixty-five studies were included. Pooled correlation coefficients for biomarkers of iron status in mothers and newborns/neonates were 0.13 (ferritin), 0.42 (hepcidin), 0.30 (serum/plasma iron), 0.09 (transferrin), 0.20 (transferrin saturation), and 0.16 (total iron binding capacity). Pooled correlation coefficients for haematological indices in mothers and newborns/neonates were 0.15 (haemoglobin), 0.15 (haematocrit), 0.25 (mean cell/corpuscular haemoglobin), 0.22 (mean cell/corpuscular volume). Interpretation Maternal biomarkers of iron and haematologic status correlate poorly with those in newborns/neonates. These results underscore a need for alternative approaches to estimate foetal/neonatal iron status and haematological indices. Funding MBO and SLB hold Canada Research Chairs, and grants from the Women and Children's Health Research Institute and Canadian Institutes of Health Research.

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Haemorheological parameters of umbilical cord blood of Nigerian newborns: correlations with maternal parameters

Cited by 16 publications

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Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study

Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

A systematic review and meta-analysis of the correlation between maternal and neonatal iron status and haematologic indices

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