Haemosiderin‐laden mesothelial cells in ascitic fluid: A soft pointer for endometriosis in a female of reproductive age

Stephen, Norton; Gochhait, Debasis; Anbalagan, Anandhi; Siddaraju, Neelaiah

doi:10.1111/cyt.12968

Cited by 1 publication

(2 citation statements)

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“…The presence and treatment of endometriosis were documented in all operative reports. To ensure consistency and accuracy when reporting results, the pathology reports for each patient were carefully examined and assessed multiple times using a standardized phrase list to recognize and collect any data about the potential presence of endometriosis, including the presence of histological markers suggestive of endometriosis, such as hemosiderin-laden macrophages, mesothelial-lined fibrous tissue, fibrosis, and fibrotic adhesions with chronic inflammation [57][58][59][60][61]. Following the evaluation, the endometriosis and/or suspicious lesions were excised and sent to the Department of Pathology at Stanford University Medical Center for histological evaluation.…”

Section: Surgical and Histological Evaluationmentioning

confidence: 99%

“…However, emerging insights indicate that certain disease variants lack endometrial-like epithelial and stromal cells [57]. In such cases, the presence of hemosiderin-laden macrophages alone indicates endometriosis [58][59][60]. In addition, a consistent presence of smooth muscle and fibrous tissue is evident across many different types of endometriosis [57,61].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence of Endometriosis in Patients with Unexplained Infertility

Nezhat,

Khoyloo,

Tsuei

et al. 2024

JCM

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Endometriosis, a systemic ailment, profoundly affects various aspects of life, often eluding detection for over a decade. This leads to enduring issues such as chronic pain, infertility, emotional strain, and potential organ dysfunction. The prolonged absence of diagnosis can contribute to unexplained obstetric challenges and fertility issues, necessitating costly and emotionally taxing treatments. While biopsy remains the gold standard for diagnosis, emerging noninvasive screening methods are gaining prominence. These tests can indicate endometriosis in cases of unexplained infertility, offering valuable insights to patients and physicians managing both obstetric and non-obstetric conditions. In a retrospective cross-sectional study involving 215 patients aged 25 to 45 with unexplained infertility, diagnostic laparoscopy was performed after unsuccessful reproductive technology attempts. Pathology results revealed tissue abnormalities in 98.6% of patients, with 90.7% showing endometriosis, confirmed by the presence of endometrial-like glands and stroma. The study underscores the potential role of endometriosis in unexplained infertility cases. Although the study acknowledges selection bias, a higher than previously reported prevalence suggests evaluating endometriosis in patients who have not responded to previous reproductive interventions may be justified. Early detection holds significance due to associations with ovarian cancer, prolonged fertility drug use, pregnancy complications, and elevated post-delivery stroke risk.

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