Haemostatic Changes Induced by Adsorbent Haemoperfusion

Winchester, James F.

doi:10.1007/978-1-349-03458-1_32

Cited by 12 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current charcoal hemoperfusion devices produce platelet losses of 30% or more [22]. Transient leukopenia, similar to that observed during hemodialysis, occurs during hemoperfusion in man, and may be a result of complement activation by surface contact, with margination of leukocytes similar to that observed during hemodialysis.…”

Section: Side Effects Of Charcoal Hemoperfusionmentioning

confidence: 81%

History of Sorbents in Uremia

Winchester

Ronco

Brady

et al. 2001

Contributions to Nephrology

View full text Add to dashboard Cite

Section: Side Effects Of Charcoal Hemoperfusionmentioning

confidence: 81%

History of Sorbents in Uremia

Winchester

Ronco

Brady

et al. 2001

Contributions to Nephrology

View full text Add to dashboard Cite

“…Current charcoal hemoperfusion devices produce platelet losses of 30% or less [13]. Transient leukopenia, similar to that observed during hemodialysis, occurs during hemoperfusion in man, and may be a result of complement activation by surface contact, with margination of leukocytes similar to that observed during hemodialysis.…”

Section: Side Effects Of Charcoal Hemoperfusionmentioning

confidence: 81%

Sorbent Augmented Dialysis: Minor Addition or Major Advance in Therapy?

et al. 2000

View full text Add to dashboard Cite

“…In humans, a wide range of platelet losses during clinical hemoperfusion has been reported, depending on the system adopted and the condition being treated; a n average 30% reduction in platelet counts occurs. 35 Chang's hemoperfusion over albumin-collodion-coated charcoal4 stands alone in not causing platelet loss in vivo.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic Changes Induced In Vitro by Hemoperfusion Over Activated Charcoal

et al. 1978

View full text Add to dashboard Cite

The effect of hemoperfusion over charcoal on changes in platelet counts, coagulation factor concentrations and standard coagulation tests were determined during a two-hour in vitro perfusion of normal blood through a column containing 20 gm of activated charcoal, either uncoated or coated with 0.5% acrylonitrile/dimethylaminoethyl methacrylate copolymer (AN/DMAEMA). With citrated whole blood, platelet counts fell by 15% during hemoperfusion over coated or uncoated charcoal and also during passage through an identical empty chamber. On the other hand, with heparinized whole blood, platelet counts fell by 90% during hemoperfusion over uncoated charcoal, and 25% during hemoperfusion over coated charcoal. The concentrations of coagulation factors ILV, IX, X and XI1 were reduced during hemoperfusion over uncoated charcoal, while those of factors I1 and X were reduced and that of factor VII increased during hemoperfusion over coated charcoal. Perfusion with heparinized, platelet-rich plasma resulted in small reductions in platelet counts, suggesting that either erythrocyte disruption or the physical effects of intact red cells play a major role in producing the hemostatic abnormalities occurring during whole blood hemoperfusion. The method described may be used to assess the hemocompatibility of polymer coatings for charcoal particles, to investigate the nature of the interaction between platelets and arti-

show abstract

Haemostatic Changes Induced by Adsorbent Haemoperfusion

Cited by 12 publications

References 13 publications

History of Sorbents in Uremia

History of Sorbents in Uremia

Sorbent Augmented Dialysis: Minor Addition or Major Advance in Therapy?

Hemostatic Changes Induced In Vitro by Hemoperfusion Over Activated Charcoal

Contact Info

Product

Resources

About