Hair cortisol and cortisone are decreased by natural sunlight

Wester, Vincent L.; Wulp, Nils R.P. van der; Koper, Jan W.; Rijke, Yolanda B. de; Rossum, Elisabeth F.C. van

doi:10.1016/j.psyneuen.2016.06.016

Cited by 78 publications

(37 citation statements)

References 16 publications

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“…In humans, not only an extreme dose of UV light, but also repeated sunlight exposure decreases the cortisol concentration of scalp hair (Wester et al 2016). External factors, such as extensive brushing or treatment with various dermatological preparations may also have a significant influence on cortisol and its concentration in hair, as was shown in sheep, where hair exposed to either extensive brushing or dexamethasone fluid had significantly higher concentrations of immunoreactive cortisol after three weeks of treatment (Salaberger 2016).…”

Section: External Factorsmentioning

confidence: 94%

Analysis of cortisol in dog hair - a potential biomarker of chronic stress: a review

Mesarčová¹,

Kottferová²,

Skurková³

et al. 2017

Vet. Med.

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Cortisol, which is produced in the adrenal glands, is an endogenous glucocorticoid hormone that delivers its hormonal message to cells by acting on glucocorticoid receptors. It is one of the main stress hormones responsible for stress responses in animals and humans, and its overproduction is characteristic of certain diseases. While acute stress disorder can be evaluated by means of measuring the cortisol concentration in blood and urine, chronic stress disorder can be detected by monitoring the cortisol concentration in fur or hair. Hair collection is simple, inexpensive and non-invasive, and can be performed easily and rapidly; thus, it appears to be a suitable method for determining the level of stress in dogs from shelters, abused dogs or dogs involved in different types of animal interactions. Since it is a relatively new method, monitoring cortisol in hair or fur requires further research in order to definitively prove its efficacy, and possibly to determine reference range values for different breeds of dogs.

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Section: External Factorsmentioning

confidence: 94%

Analysis of cortisol in dog hair - a potential biomarker of chronic stress: a review

Mesarčová¹,

Kottferová²,

Skurková³

et al. 2017

Vet. Med.

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“…These included child age(Dettenborn, Tietze, Kirschbaum, & Stalder, 2012), sex(Dettenborn et al, 2012;Gray et al, 2018;Simmons et al, 2016), and season of hair sample collection as a proxy for sun exposure(Wester, van der Wulp, Koper, de Rijke, & van Rossum, 2016). These included child age(Dettenborn, Tietze, Kirschbaum, & Stalder, 2012), sex(Dettenborn et al, 2012;Gray et al, 2018;Simmons et al, 2016), and season of hair sample collection as a proxy for sun exposure(Wester, van der Wulp, Koper, de Rijke, & van Rossum, 2016).…”

mentioning

confidence: 99%

Hair cortisol as a measure of the stress response to social adversity in young children

Bryson

Goldfeld

Price

et al. 2019

Developmental Psychobiology

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Hair cortisol has the potential to provide insight into young children's long-term stress response to social adversity. This study investigated associations between children's exposure to adversity from pregnancy to 2 years of age and their hair cortisol at 2 years, using a longitudinal cohort of children enriched for adversity risk, whose mothers were recruited during pregnancy through the "right@home" trial. Exposures were 18 maternal socioeconomic and psychosocial indicators of adversity, examined as concurrent, cumulative, and longitudinal exposure from pregnancy to 2 years. Hair samples were analyzed from 319/603 (53%) children participating at 2 years.Multivariable regression analyses for concurrent exposure showed three indicators of adversity were associated with higher hair cortisol (housing tenure of public rental, paying board or living rent free; not living in a safe place; higher maternal stress symptoms), one with lower hair cortisol (housing problems), and 14 indicators with no evidence of association. There was no evidence of association for the cumulative adversity count. Longitudinal exposure showed "intermittent" and "persistent" high maternal stress symptoms were associated with higher hair cortisol. The small number of associations identified suggests that hair cortisol is limited as a measure of stress response to social adversity in children at 2 years. K E Y W O R D Sadverse childhood experiences, child, hair cortisol, social adversity, stress

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“…In several studies [11,14,27], overall hair cortisol values may be overestimated due to lack of isopropanol washings to remove sweat cortisol contamination, and mincing, instead of grinding, may have reduced the yield of actual cortisol from inside the individual hairs. Excessive shampoo washings and hair dyeing [28,29] and prolonged exposure to UV light [30] can diminish quantification in hair samples (Fig. 3a), as supported by findings in a large cohort without psychiatric disease [31].…”

Section: Discussionmentioning

confidence: 68%

“…For simplicity, it is assumed that lipophilic cortisol diffuses from vessel to hair shaft via simple diffusion, similar to how illicit drugs are suspected of being incorporated into hair [45,46]. (A) Excessive shampoo washings and hair dyeing [28,29] can leach cortisol from hair, and prolonged exposure to UV light causes photo-degradation or cross-linking of glucocorticoid molecules [30], decreasing the quantification of cortisol measured in hair. (B) Assuming that skin has local HPA-like activity and appropriate negative feedback loops [33,36], the production and dynamics of locally-synthesized CRH and ACTH should be negligible under systemic suppression in chronic hypercortisolism as in murine models [47].…”

Section: Figmentioning

confidence: 99%

Hair cortisol in the evaluation of Cushing syndrome

et al. 2017

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Purpose Hair cortisol evaluation has been used to help detect patients with suspected Cushing Syndrome. Our goal was to correlate segmental hair cortisol with biochemical testing in patients with Cushing syndrome and controls. This study was a prospective analysis of hair cortisol in confirmed Cushing syndrome cases over 16 months. Methods Thirty six subjects (26.5±18.9 years, 75% female, and 75% Caucasian) were analyzed by diurnal serum cortisol, 24 h urinary free cortisol corrected for body surface area (UFC/BSA), and 24 h urinary 17-hydroxysteroids corrected for creatinine (17OHS/Cr). Thirty patients were diagnosed with Cushing syndrome, and six were defined as controls. 3-cm hair samples nearest to the scalp, cut into 1-cm segments (proximal, medial, and distal), were analyzed for cortisol by enzyme immunoassay and measured as pmol cortisol/g dry hair. Hair cortisol levels were compared with laboratory testing done within previous 2 months of the evaluation. Results Proximal hair cortisol was higher in Cushing syndrome patients (266.6 ± 738.4 pmol/g) than control patients (38.9 ± 25.3 pmol/g) (p = 0.003). Proximal hair cortisol was highest of all segments in 25/36 (69%) patients. Among all subjects, proximal hair cortisol was strongly correlated with UFC/BSA (r=0.5, p=0.005), midnight serum cortisol (r=0.4, p=0.03), and 17OHS/Cr, which trended towards significance (r=0.3, p=0.06). Conclusions Among the three examined hair segments, proximal hair contained the highest cortisol levels and correlated the most with the initial biochemical tests for Cushing syndrome in our study. Further studies are needed to validate proximal hair cortisol in the diagnostic workup for Cushing syndrome.

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Hair cortisol and cortisone are decreased by natural sunlight

Cited by 78 publications

References 16 publications

Analysis of cortisol in dog hair - a potential biomarker of chronic stress: a review

Analysis of cortisol in dog hair - a potential biomarker of chronic stress: a review

Hair cortisol as a measure of the stress response to social adversity in young children

Hair cortisol in the evaluation of Cushing syndrome

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