Hair darkening in porphyria cutanea tarda

Shaffrali, F.; McDonagh, A.J.G.; Messenger, A.G.

doi:10.1046/j.1365-2133.2002.04591.x

Cited by 40 publications

(22 citation statements)

References 27 publications

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“…8 Besides induction by drugs, repigmentation of white hair has been observed in several settings, such as after radiation therapy or psoralen plus UVA treatment, after inflammatory processes affecting the scalp, in porphyria cutanea tarda or as a spontaneous event. 18 Although drug-induced repigmentation was the most probable explanation for the hair-colour change in our patient, the relation between drug intake and hair darkening would have been proven only if hair had returned to its original colour after drug withdrawal. We were unable to make such an observation as the patient continued treatment.…”

Section: Discussionmentioning

confidence: 93%

Repigmentation and curling of hair after acitretin therapy

Seçkin

Yildiz

2009

Aust J Dermatology

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Section: Discussionmentioning

confidence: 93%

Repigmentation and curling of hair after acitretin therapy

Seçkin

Yildiz

2009

Aust J Dermatology

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“…However, most studies differentiate follicles on the basis of the level of pigmentation, not donor age. We also know that hair graying may be partially reversed in some skin disorders or after certain drug therapies (Reynolds et al, 1998;Shaffrali et al, 2002). Thus, graying may not necessarily indicate a complete deletion of the melanocyte stem cell population.…”

mentioning

confidence: 96%

Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase

Kauser

Westgate

Green

et al. 2011

Journal of Investigative Dermatology

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still whereas others actively migrated in the DNFB-applied skin. We assume that this distinct migratory activity may be due to the fact that not all T cells in the LNs after DNFB sensitization were DNFB specific. In contrast, almost all TNCB-sensitized T cells actively migrated when DNFB was applied. In addition, we showed reverse motile activities in the TNCB-painted skin. Moreover, skin-infiltrating T cells colocalized with APCs. These findings suggest that skin-infiltrating T cells may actively scan for antigens, and when they meet APCs carrying their specific antigens, they stop migrating and stably interact with APCs. Our results also indicate that in the elicitation phase of CHS, hapten seems to be presented mainly by APCs in the dermis. Additional detailed studies are needed to clarify which subset of dermal APCs is essential for hapten presentation and whether epidermal Langerhans cells contribute.

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“…[73][74][75]), combined with the vitiligo-pseudocatalase experience of repigmenting eyelashes [69] and the new findings of catalase depletion in grey hair follicles [72], led to the development of numerous 'anti-greying' strategies and products. The dietary consumption of catalaserich foods such as spinach and avocado was suggested as a natural solution for reducing hair greying, and catalase-based nutritional supplements, containing both pure catalase and tyrosine, or comprising plant extracts that claim to boost catalase activity, are now commercially available.…”

Section: Hydrogen Peroxide Accumulation and Antioxidative Enzyme Deplmentioning

confidence: 99%

Age‐induced hair greying – the multiple effects of oxidative stress

Seiberg¹

2013

Intern J of Cosmetic Sci

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SynopsisAn obvious sign of ageing is hair greying, or the loss of pigment production and deposition within the hair shafts. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. One key issue that is in common to these processes is oxidative damage. At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene (BCL-2) depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. Melanotic bulbar melanocytes express high levels of BCL-2 to enable survival from melanogenesis-and ultraviolet A (UVA)-induced reactive oxygen species (ROS) attacks. With ageing, the bulbar melanocyte expression of anti-oxidant proteins such as BCL-2, and possibly TRP-2, is reduced, and the dedicated enzymatic anti-oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress. A marked reduction in catalase expression and activity results in millimolar accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Interestingly, amelanotic melanocytes at the outer root sheath (ORS) are somewhat less affected by these processes and survive for longer time even within the white, ageing hair follicles. Better understanding of the overtime susceptibility of melanocytes to oxidative stress at the different follicular locations might yield clues to possible therapies for the prevention and reversal of hair greying.R esum e Un signe evident du vieillissement est le grisonnement des cheveux ou la perte de la production de pigment et de son d epôt dans les follicules pileux. De nombreux m ecanismes, agissant a diff erents niveaux et endroits folliculaires, contribuent aux cheveux grisonnants, allant des dommages aux cellules souches m elanocytaires a la mort des m elanocytes folliculaires. Une question cl e qui est commune a ces processus concerne le dommage oxydatif. Au niveau de la niche des cellules souches du follicule, le stress oxydatif, acc el er e par l'appauvrissement de BCL-2, conduit a l'apoptose et a une diminution s elective des cellules souches des m elanocytes, ce qui r eduit le repeuplement des follicules anag enes nouvellement form es. Les m elanocytes bulbaires m elaniques expriment des niveaux elev es de Bcl-2 pour permettre la survie suite a l'attaque par les esp eces r eactives de l'oxyg ene (ROS) induites par la m elanog en ese et les ultraviolets A (UVA). Avec le vieillissement, l'expression dans m elanocytes du bulbe des prot eines anti-oxydantes comme BCL-2, et peut-être TRP-2, est r eduite, et la d efense sp ecifique du syst eme antioxydant enzymatique faiblit a travers le follicule, r esultant en un plus grand stress oxydatif. Une r eduction marqu ee de l'expression catalase et les r esultats de l'activit e de l'accumulation millimolaire de peroxyde d'hydrog ene contribuent a un dysfonctionnement et a la mort des m elanocytes b...

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Hair darkening in porphyria cutanea tarda

Cited by 40 publications

References 27 publications

Repigmentation and curling of hair after acitretin therapy

Repigmentation and curling of hair after acitretin therapy

Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase

Age‐induced hair greying – the multiple effects of oxidative stress

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