Hair Dye and Cancer: Reassuring Evidence of No Association

Colditz, Graham A.

doi:10.1093/jnci/86.3.164

Cited by 6 publications

(1 citation statement)

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“…The true relationship between personal hair dye use and bladder cancer has remained uncertain. Although some in the scientific community suggest that no causal association exists, 26 there is a clear lack of consensus 14 and persistent public interest. This analysis was designed to address the current uncertainty and provide a systematic, quantitative, and qualitative evaluation of existing data.…”

Section: Discussionmentioning

confidence: 99%

Personal Use of Hair Dyes and the Risk of Bladder Cancer: Results of a Meta-Analysis

Huncharek

Kupelnick²

2005

Public Health Rep

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SYNOPSISObjective. This study examined the methodology of observational studies that explored an association between personal use of hair dye products and the risk of bladder cancer.Methods. Data were pooled from epidemiological studies using a general variancebased meta-analytic method that employed confidence intervals. The outcome of interest was a summary relative risk (RRs) reflecting the risk of bladder cancer development associated with use of hair dye products vs. non-use. Sensitivity analyses were performed to explain any observed statistical heterogeneity and to explore the influence of specific study characteristics of the summary estimate of effect.Results. Initially combining homogenous data from six case-control and one cohort study yielded a non-significant RR of 1.01 (0.92, 1.11), suggesting no association between hair dye use and bladder cancer development. Sensitivity analyses examining the influence of hair dye type, color, and study design on this suspected association showed that uncontrolled confounding and design limitations contributed to a spurious non-significant summary RR. The sensitivity analyses yielded statistically significant RRs ranging from 1.22 (1.11, 1.51) to 1.50 (1.30, 1.98), indicating that personal use of hair dye products increases bladder cancer risk by 22% to 50% vs. non-use.Conclusion. The available epidemiological data suggest an association between personal use of hair dye products and increased risk of bladder cancer.

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Section: Discussionmentioning

confidence: 99%