Hair dysmorphology in the R6/1 and R6/2 mouse models of Huntington’s disease

Pierzynowska, Karolina; Podlacha, Magdalena; Łuszczek, Dorota; Rintz, Estera; Gaffke, Lidia; Szczudło, Zuzanna; Tomczyk, Marta; Smoleński, Ryszard T.; Węgrzyn, Grzegorz

doi:10.1016/j.gene.2020.145133

Cited by 4 publications

(7 citation statements)

References 29 publications

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“…Saliva was demonstrated to contain detectable levels of tHTT, correlating with some HD clinical measures [ 38 ] and feces was used to detect bacterial alterations related to clinical features [ 39 ]. Finally, hair cortisol content and hair morphology were also hypothesized to be potential prognostic and predictive biomarkers [ 39 , 40 ]. Figure created in .…”

Section: Current Biomarkers In Huntington’s Diseasementioning

confidence: 99%

“…Accordingly, hypocortisolism was already associated with early stages HD patients, possibly due to Hypothalamic–Pituitary–Adrenal (HPA) axis dysfunction [ 47 ]. In support of hair as a possible non-invasive source of biomarkers, studies on R6/1 and R6/2 HD mouse models revealed significantly different hair morphology compared to WT mice [ 40 ]. This might be of particular interest since, in other metabolic disorders such as Mucopolysaccharidoses (MPS), hair dysmorphology could be identified and then recovered after enzyme-based therapy [ 48 ], possibly revealing an easily-available predictive biomarker.…”

Section: Current Biomarkers In Huntington’s Diseasementioning

confidence: 99%

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Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease

Pellegrini

Bergonzoni

Perrone

et al. 2022

Genes

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Whether as a cause or a symptom, RNA transcription is recurrently altered in pathologic conditions. This is also true for non-coding RNAs, with regulatory functions in a variety of processes such as differentiation, cell identity and metabolism. In line with their increasingly recognized roles in cellular pathways, RNAs are also currently evaluated as possible disease biomarkers. They could be informative not only to follow disease progression and assess treatment efficacy in clinics, but also to aid in the development of new therapeutic approaches. This is especially important for neurological and genetic disorders, where the administration of appropriate treatment during the disease prodromal stage could significantly delay, if not halt, disease progression. In this review we focus on the current status of biomarkers in Huntington’s Disease (HD), a fatal hereditary and degenerative disease condition. First, we revise the sources and type of wet biomarkers currently in use. Then, we explore the feasibility of different RNA types (miRNA, ncRNA, circRNA) as possible biomarker candidates, discussing potential advantages, disadvantages, sources of origin and the ongoing investigations on this topic.

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Section: Current Biomarkers In Huntington’s Diseasementioning

confidence: 99%

Section: Current Biomarkers In Huntington’s Diseasementioning

confidence: 99%

Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease

Pellegrini

Bergonzoni

Perrone

et al. 2022

Genes

View full text Add to dashboard Cite

show abstract

“…The morphological observation was carried out with the aid of a scanning electron microscope (SEM) in order to detect the differences in the morphology and density (the degree of dispersion of hair) of the hair of the mice in each group. Hair stands were withdrawn from mice using scissors, SEM analyses were performed as described previously [21] with JEOL JCM-6000 microscope (Tokyo, Japan) operating at an acceleration voltage of 15 kV. For semiquantitative assessment of the mouse hair dysmorphology, the previously proposed scale of hair morphological changes was used [21].…”

Section: Body Hair Characteristics Of Micementioning

confidence: 99%

“…Hair stands were withdrawn from mice using scissors, SEM analyses were performed as described previously [21] with JEOL JCM-6000 microscope (Tokyo, Japan) operating at an acceleration voltage of 15 kV. For semiquantitative assessment of the mouse hair dysmorphology, the previously proposed scale of hair morphological changes was used [21]. In addition, the hair surface microstructure was identified by analyzing the formation of epidermal scales in SEM images [22].…”

Section: Body Hair Characteristics Of Micementioning

confidence: 99%

Fortified Fermented Rice-Acid Can Regulate the Gut Microbiota in Mice and Improve the Antioxidant Capacity

Liu

Qin

et al. 2021

Nutrients

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The study aimed to explore the effects of fortified fermented rice-acid on the antioxidant capacity of mouse serum and the gut microbiota. Hair characteristics, body mass index, intestinal villus height, intestinal crypt depth, serum antioxidant capacity, and gut microbiota of mice were first measured and the correlation between the antioxidant capacity of mouse serum and the gut microbiota was then explored. The mice in the lactic acid bacteria group (L-group), the mixed bacteria group (LY-group), and the rice soup group (R-group) kept their weight well and had better digestion. The mice in the L-group had the better hair quality (dense), but the hair quality in the R-group and the yeast group (Y-group) was relatively poor (sparse). In addition, the inoculation of Lactobacillus paracasei H4-11 (L. paracasei H4-11) and Kluyveromyces marxianus L1-1 (K. marxianus L1-1) increased the villus height/crypt depth of the mice (3.043 ± 0.406) compared to the non-inoculation group (R-group) (2.258 ± 0.248). The inoculation of L. paracasei H4-11 and K. marxianus L1-1 in fermented rice-acid enhanced the blood antioxidant capacity of mouse serum (glutathione 29.503 ± 6.604 umol/L, malonaldehyde 0.687 ± 0.125 mmol/L, catalase 15.644 ± 4.618 U/mL, superoxide dismutase 2.292 ± 0.201 U/mL). In the gut microbiota of L-group and LY-group, beneficial microorganisms (Lactobacillus and Blautia) increased, but harmful microorganisms (Candidatus Arthromitus and Erysipelotrichales) decreased. L. paracasei H4-11 and K. marxianus L1-1 might have a certain synergistic effect on the improvement in antibacterial function since they reduced harmful microorganisms in the gut microbiota of mice. The study provides the basis for the development of fortified fermented rice-acid products for regulating the gut microbiota and improving the antioxidant capacity.

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“…An interesting suggestion is to evaluate the average monthly concentration of cortisol in hair, which, when combined with the analysis of its plasma level, can give a complete picture of the changes in HPA axis activity ( Russell et al, 2012 ). Our team also explored the possibility of using changes in hair morphology as a potential non-invasive marker useful in Huntington's disease ( Pierzynowska et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease

Podlacha

Pierzynowska

Gaffke

et al. 2022

Brain, Behavior, & Immunity - Health

Self Cite

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Hair dysmorphology in the R6/1 and R6/2 mouse models of Huntington’s disease

Cited by 4 publications

References 29 publications

Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease

Current Diagnostic Methods and Non-Coding RNAs as Possible Biomarkers in Huntington’s Disease

Fortified Fermented Rice-Acid Can Regulate the Gut Microbiota in Mice and Improve the Antioxidant Capacity

Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease

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