Hair Growth-Promoting Mechanisms of Red Ginseng Extract through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health

Abstract

This study aimed to investigate the underlying mechanisms of red ginseng extract (RGE) on regulating hair growth and hair follicle development. Results from in vitro studies showed that RGE treatment simultaneously enhanced viability and inhibited apoptosis in human hair dermal papilla cells. Moreover, RGE administration promoted telogen-toanagen transition, prolonged anagen in hair follicular cycling, and increased the size of hair follicles and skin thickness in a C57BL/6 mouse model. Furthermore, RGE treatment significantly upregulated the expression of β-catenin, phospho-glycogen synthase kinase 3β, cyclin D1, cyclin E, and Bcl-2, phospho-extracellular signal-regulated protein kinase, and phospho-Akt, which are associated with promoting hair growth. In addition, RGE enhanced skin health by activation of antioxidant defense systems. Our data demonstrates that hair regenerative mechanisms of RGE may be mediated by stimulating dermal papilla cell proliferation and enhancing skin functions.

Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing

“…In the past reports, red ginseng extract, ginsenosides Rb1 and Rg3 enhanced the proliferation of human dermal papilla cells (hDPCs) and hair matrix keratinacyte, activate ERK and AKT signaling pathways in hDPCs, and inhibit the transcription of DHT-induced androgen receptors, promoted hair growth in C57BL/6 mice [ 51 ]. Other research demonstrated that hair regenerative mechanisms of red ginseng extract may be mediated by stimulating dermal papilla cell proliferation and enhancing skin functions [ 52 ]. In our results, the phosphorylation of ERK and AKT were increased in target cells.…”

CircAGK regulates high dihydrotestosterone‐induced apoptosis in DPCs through the miR‐3180‐5p/BAX axis

“…7 Traditional treatments, that is, finasteride and minoxidil, have not shown the ability to reverse the fate of terminal atrophic hair follicles in clinical trials. 8 New treatments include stem cells and their products, 9 peroxidases, 10 prostaglandin derivatives, 11 Chinese medicine molecules, 12 and photoelectric therapy, 13 all of which mediate hair follicle regeneration by regulating apoptosis. The stability and regulatory mechanisms of the above treatments remain to be elucidated.…”

Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice

“…Hair loss can be attributed to multiple factors, including genetics, hormonal imbalances, stress, diet, and certain medications. These factors can cause the shrinkage of hair follicles, leading to thinner and shorter hair shafts, ultimately resulting in balding or thinning areas ( Cotsarelis and Millar, 2001 ; Truong and Jeong, 2021 ). Identifying the underlying cause and employing hair restoration procedures are effective strategies for the treatment of hair loss and promoting regrowth.…”