Half-life determination of serum free prostate-specific antigen following radical retropubic prostatectomy

Richardson, Thomas D.; Wojno, Kirk J.; Liang, Leonard W.; Giacherio, Donald; England, Barry G.; Henricks, Walter H.; Schork, Anthony; Öesterling, Joseph E.

doi:10.1016/s0090-4295(96)00608-5

Cited by 36 publications

(16 citation statements)

References 16 publications

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“…There is universal agreement that fPSA follows a two-compartment model of elimination, with the a-phase ranging from 0.57 to 1.8 h, and the b-phase half-life lasting 6.0-22 h. 16,18,19,24,25,28 Our results agree with this two-phase cPSA and fPSA elimination BJ Martin et al pattern of elimination, but our calculated half-lives appear to be much shorter than those previously published, with an initial half-life of 0.50 h and a later half-life of 4.20 h. Again, this suggests African-American men eliminate fPSA faster than Caucasian men. There are currently three theories to explain the two-compartment model of fPSA elimination.…”

Section: Discussionmentioning

confidence: 91%

“…[17][18][19] cPSA, however, is too large for glomerular filtration; in fact, Semjonow et al, 20 failed to detect total PSA in the urine following radical prostatectomy. Receptors for serpinenzyme complexes have been discovered on the surface of hepatocytes, 21,22 suggesting hepatic metabolism of PSA complexes.…”

Section: Discussionmentioning

confidence: 99%

“…The first theory asserts that fPSA is rapidly excreted by the kidneys, consistent with its low molecular weight, which accounts for its faster, initial phase elimination. 18,19,28 A second theory states that fPSA forms complexes in the serum with protease-inhibitors, thus rendering it undetectable by fPSA assay methods but not truly removing it from circulation. 23,29 Stephan et al, 24 lent support to this theory by demonstrating constant levels of cPSA while fPSA levels dropped in the immediate postoperative period.…”

Section: Discussionmentioning

confidence: 99%

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cPSA and fPSA elimination in African-American men

Martin

Cheli

Davis

et al. 2003

Prostate Cancer Prostatic Dis

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In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an a-phase elimination of 0.50 h and a b-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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cPSA and fPSA elimination in African-American men

Martin

Cheli

Davis

et al. 2003

Prostate Cancer Prostatic Dis

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“…In this series, the level of PSA ranged from 0.6 to 4.8 ng/ml when only BPH tissue was present in the biopsy. Considering that every gram of BPH tissue produces an average of 0.31 ng/ml PSA [30, 31], it seems rather unlikely that around 2–15 g of BPH tissue was left in place after surgery or was otherwise capable of such a fast regrowth. PSA doubling time in these cases ranged from 7.3 to 100 months and increased in an exponential manner.…”

Section: Remaining Bph Tissue After Rpmentioning

confidence: 99%

Salvage Radiotherapy in Patients with Persisting Prostate-Specific Antigen after Radical Prostatectomy for Prostate Cancer

Bottke¹,

Wiegel²,

Höcht³

et al. 2003

Oncology

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Salvage radiotherapy in patients with persisting prostate-specific antigen (PSA) after radical prostatectomy for prostate cancer offers an approach to reduce local recurrence rates and to improve the rate of biochemical freedom from relapse. 30–70% of these patients experience a decrease in their PSA to an undetectable range; in about 40–50% of these patients, PSA remains stable after 5 years. Therefore, radiation therapy offers these patients an ultimate chance of cure. The pre-irradiation PSA value is of particular importance. The PSA level should not exceed 2 ng/ml because otherwise the rate of distant metastases increases significantly. Serious side effects are apparently low, thus confirming the suitability of this therapeutic approach.

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“…The molecular weight of FPSA is compatible with some accumulation due to a decrease in glomerular filtration. Richardson et al [9] recently demonstrated that FPSA has a normal half-life of 110 min compared to 2-3 days for the PSA complex. They postulated that renal clearance is the mechanism involved in FPSA elimination and our results support this view.…”

Section: Commentsmentioning

confidence: 99%

Effect of Terminal Renal Failure on the Ratio of Free to Total Prostate-Specific Antigen

Douville¹,

Tiberi²

1998

Tumor Biol

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Objectives: To evaluate the effect of terminal renal failure on the ratio of free to total prostate-specific antigen (PSA). Methods: We measured free and total PSA in a group of 48 men on chronic hemodialysis. Samples were taken before dialysis and compared with a control group of 101 men without known prostatic or renal disease. Measurements of total and free PSA were made simultaneously with an ES-300 analyzer from Boehringer Mannheim according to the manufacturer’s instructions. Results: Patients on hemodialysis have lower complexed PSA but higher free PSA than controls. Therefore, we observed a markedly higher calculated proportion of free PSA in the dialysis group (0.54 ± 0.16 vs. 0.33 ± 0.14, p < 0.00001). The calculated proportion of free PSA decreases progressively as the levels of total PSA increases from 0 to 4 µg/l in both groups. By multivariate analysis, total PSA (p < 0.00001) and dialysis (p < 0.00001) were independent predictors of the fraction of free PSA. Age had no significant effect after correction for total PSA (p = 0.23). Conclusion: Patients on hemodialysis have normal total PSA but a significantly higher proportion of free PSA. Caution is therefore recommended for the interpretation of free PSA in that population since cutoff established in patients without renal disease may be inappropriate.

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Half-life determination of serum free prostate-specific antigen following radical retropubic prostatectomy

Cited by 36 publications

References 16 publications

cPSA and fPSA elimination in African-American men

cPSA and fPSA elimination in African-American men

Salvage Radiotherapy in Patients with Persisting Prostate-Specific Antigen after Radical Prostatectomy for Prostate Cancer

Effect of Terminal Renal Failure on the Ratio of Free to Total Prostate-Specific Antigen

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