Half-sandwich ruthenium(II) complexes with N- and N,(N,O)-donor ligands: molecular, electronic structures, and computational study

Małecki, Jan Grzegorz

doi:10.1007/s11224-011-9890-0

Cited by 34 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both the complexes displayed the d – d transition bands corresponding to a pseudo‐octahedral geometry, in the ranges of of ν 1 =350–360 nm and ν 2 =410–415 nm attributed to the 1 A 1 → 1 B 2 and 1 A 1 → 1 B 1 transitions respectively, while the low‐energy band due to the expected 1 A 1 → 1 A 2 transition was not observed. These assignments and analyses were in line with previous report for similar type of half‐sandwich ( para ‐cymene)Ru(II) complexes …”

Section: Resultssupporting

confidence: 92%

(para‐Cymene)Ru(II) Complexes with Chelating Benzotriazole Ligands: Application in Oxidation and Reduction Catalysis

2020

View full text Add to dashboard Cite

1‐Heteroaryl‐substituted benzotriazole motifs represent a new class of bidentate chelating ligands for several transition metals. Although metal complexes having such ligands in tris‐ and bis‐chelated binding have been extensively studied, investigation of mono‐chelated metal complexes, especially their structural and catalytic properties, is rarely explored. In this work, two such complexes – [(para‐cymene)Ru(BTZ‐2P)Cl]PF6 and [(para‐cymene)Ru(BTZ‐2Q)Cl]PF6, (BTZ‐2P=1‐(pyridine‐2‐yl)‐1H‐benzo[d][1,2,3]triazole; BTZ‐2Q=1‐(quinoline‐2‐yl)‐1H‐benzo[d][1,2,3]triazole) have been synthesized and characterized through various spectroscopic method and X‐ray crystallography. Their electronic spectra and electrochemical properties have also been explored. Both the complexes have been successfully applied in two types of important catalytic processes – (a) oxidation of aryl olefins to corresponding aromatic carbonyl compounds, and (b) transfer hydrogenation of aromatic carbonyl compounds to the corresponding alcohols.

show abstract

Section: Resultssupporting

confidence: 92%

(para‐Cymene)Ru(II) Complexes with Chelating Benzotriazole Ligands: Application in Oxidation and Reduction Catalysis

2020

View full text Add to dashboard Cite

show abstract

“…The FTIR spectrum of the Hapbim ligand shows characteristic bands at 3383 and 3140 cm −1 assigned to the stretching vibrations of NH 2 and ν(NH) of benzimidazole, respectively [ 23 , 31 , 32 , 33 ]. In the complexes, the band due to NH 2 was shifted to a lower frequency (3240–3251 cm −1 ) as a result of the coordination, while the NH band did not show a significant shift, confirming non-coordination to the metal center.…”

Section: Resultsmentioning

confidence: 99%

“…Heterocyclic nitrogen-containing ligands are interesting compounds in themselves due both to their structural diversity and variety of pharmaceutical applications. Benzimidazole-containing compounds are a class of these compounds that often exhibit anti-inflammatory, antifungal, antibacterial, antioxidant, and antitumor activity [ 23 , 24 ]. These compounds also readily coordinate to metal ions, and their structure, flexibility, and bulkiness can all affect the cytotoxic properties of the resulting complexes [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity

et al. 2020

View full text Add to dashboard Cite

New anticancer ruthenium(II/III) complexes [RuCl2(DMSO)2(Hapbim)] (1) and [RuCl3(DMSO) (Hapbim)] (2) (Hapbim = 2-aminophenyl benzimidazole) have been synthesized and characterized, and their chemotherapeutic potential evaluated. The interaction of the compounds with DNA was studied by both UV-Visible and fluorescence spectroscopies, revealing intercalation of both the Hapbim ligand and the Ru complexes. The in vitro cytotoxicity of the compounds was tested on human breast cancer (MCF7), human colorectal cancer (Caco2), and normal human liver cell lines (THLE-2), with compound (2) the most potent against cancer cells. The cytotoxic effect of (2) is shown to correlate with the ability of the Ru(III) complex to induce apoptosis and to cause cell-cycle arrest in the G2/M phase. Notably, both compounds were inactive in the noncancerous cell line. The anticancer effect of (2) has also been studied in an EAC (Ehrlich Ascites Carcinoma) mouse model. Significantly, the activity of the complex was more pronounced in vivo, with removal of the cancer burden at doses that resulted in only low levels of hepatotoxicity and nephrotoxicity. An apoptosis mechanism was determined by the observation of increased Bax and caspase 3 and decreased Bcl2 expression. Furthermore, (2) decreased oxidative stress and increased the levels of antioxidant enzymes, especially SOD, suggesting the enhancement of normal cell repair. Overall, compound (2) shows great potential as a chemotherapeutic candidate, with promising activity and low levels of side effects.

show abstract

“…For unambiguous determination of the influence of compounds structure on their UV-Vis radiation absorption, density functional theory (DFT) and time-dependent density functions theory (TD-DFT) calculations have been performed. DFT and TD-DFT are commonly used to study the electronic structure of coordination compounds of transition metals [34,35]. They are easy to use and fast enough to study even relatively large molecules [36].…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into Influence of Isomerism on Properties of Open Shell Cobalt Coordination System

et al. 2019

View full text Add to dashboard Cite

The two coordination compounds of cobalt were designed and synthesized. The substrates were carefully selected to allow gentle tuning of the molecular structure of the designed compounds. The crystal, molecular and supramolecular structure of studied compounds has been determined and discussed. The spectroscopic and thermal properties of designed coordination compounds have been studied and their application as precursors for the synthesis of cobalt oxide nanoparticles has been demonstrated. It was proven that not only are parameters of conversion of the precursor to nanoparticles important, but also small changes in molecular structure can considerably affect the size of formed particles. For unambiguous determination of the influence of compounds structure on their UV-Vis radiation absorption, density functional theory and time-dependent density functions theory calculations have been performed. The complexity of the correct ab-initio reflection of the open shell molecular system was outlined and discussed. The results obtained from density functional theory (DFT) calculations have been also employed for discussion of the bonding properties.

show abstract

Half-sandwich ruthenium(II) complexes with N- and N,(N,O)-donor ligands: molecular, electronic structures, and computational study

Cited by 34 publications

References 36 publications

(para‐Cymene)Ru(II) Complexes with Chelating Benzotriazole Ligands: Application in Oxidation and Reduction Catalysis

(para‐Cymene)Ru(II) Complexes with Chelating Benzotriazole Ligands: Application in Oxidation and Reduction Catalysis

Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity

Structural Insights into Influence of Isomerism on Properties of Open Shell Cobalt Coordination System

Contact Info

Product

Resources

About