Hallazgo de Dioctophyme renale en la cavidad torácica de un canino

Meyer, Sabine; Rosso, M.; Maza, Yanina

doi:10.30972/vet.2411166

Cited by 12 publications

(2 citation statements)

References 2 publications

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“…que se contamina através da ingestão dos ovos contendo larvas do parasito em primeiro estágio (L1), ao eclodirem no intestino do hospedeiro intermediário, estas larvas sofrem metamorfose para forma infectante (L2), que pode ser ingerida por peixes, rãs ou girinos que servem como hospedeiros paratênicos, e posteriormente serão ingeridos pelo cão, completando seu ciclo (Roque, 2018;Pizzinatto 2019). O D. renale, acomete principalmente o rim direito e as enzimas esofágicas liberadas pelo parasito causam necrose nos locais atingidos, possibilitando penetração na cápsula renal causando destruição e atrofia do parênquima, restando em casos avançados de parasitismo uma cápsula fibrosa associada à dilatação pélvica e repleta de fluido necro-hemorrágico, podendo conter ovos (Kommers, 1999;Mech & Tracy, 2001;Pedrassani & Nascimento, 2015;Sapin, 2017;Meyer, 2013).…”

Section: Introductionunclassified

Alterações anatomopatológicas e parâmetros bioquímicos séricos e urinários em cães com diagnóstico de Dioctophyme renale

Valle

Caye

Sapin

et al. 2022

RSD

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Animais acometidos por Dioctophyme renale geralmente são assintomáticos e o diagnóstico definitivo é o exame de imagem e o anatomopatológico. Desta forma, este estudo tem como objetivo descrever os parâmetros bioquímicos de sangue e urina e exames anatomopatológicos de 15 cães diagnosticados com D. renale na região de Pelotas-Rio Grande do Sul-RS. Foram obtidos dados de anamnese e exames laboratoriais sorológicos e urinários de protocolos de atendimento de animais no Hospital de Clínicas Veterinárias da Universidade Federal de Pelotas-UFPel, e análises anatomopatológicas pelo Serviço de oncologia SOVET/UFPEL. Foram observadas alterações macroscópicas em todas as amostras, sendo a atrofia do parênquima renal e espessamento da cápsula as mais frequentes. O exame histopatológico revelou substituição do tecido renal por fibrose, glomeruloesclerose e eventualmente presença de ovos do parasito. Em relação aos parâmetros sanguíneos e urinários, apenas um dos animais apresentou alteração nos valores de referência de ureia sérica e todos apresentaram creatinina dentro dos parâmetros considerados normais. Na urinálise havia presença de proteínas, sangue oculto, cilindros granulares, cristais e ovos do parasito. Os testes estatísticos mostraram correlação entre a evolução e grau das lesões renais com parâmetros alterados, porém mesmo em cães que apresentavam lesões de insuficiência renal aguda (IRA), haviam lesões concomitantes de insuficiência renal crônica (IRC). Como conclusão dos dados obtidos, parâmetros séricos e urinários isoladamente não refletem o real comprometimento do rim afetado, mas associados ao grau de lesão renal são aliados para um melhor estadiamento dos animais acometidos.

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Section: Introductionunclassified

Alterações anatomopatológicas e parâmetros bioquímicos séricos e urinários em cães com diagnóstico de Dioctophyme renale

Valle

Caye

Sapin

et al. 2022

RSD

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“…As enzimas esofágicas liberadas pelo parasito causam necrose nos locais atingidos, o que possibilita a penetração e destruição renal [11]. O parasito ainda pode ser encontrado no peritônio, glândula mamária, bolsa escrotal, tecido subcutâneo, útero, ovário, cavidade torácica, pericárdio, linfonodo mesentérico e no espaço intra-dural [2,5,9,16]. A severidade da lesão é dependente da quantidade de parasitos que acometem o rim, a duração da infecção, número de rins envolvidos e da ocorrência de doença renal concomitante [11].…”

Section: Introductionunclassified

Anatomopathologic Study of Kidneys parasitized by Dioctophyme renale in Dogs

Sapin

Silva-Mariano

Piovesan

et al. 2017

Acta Scientiae. Vet.

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Background: Dioctophymiasis is a disease caused by the nematode Dioctophyme renale and is a relatively common condition in dogs. The parasite affects the kidney, especially the right, enters the kidney capsule and causes destruction and atrophy of the parenchyma. The lesion severity depends on the amount of parasites affecting the kidney, the duration of the infection, number of kidneys involved and concurrent occurrence of kidney disease. The disease’s clinical presentation may be asymptomatic or with nonspecific clinical signs. The diagnosis is based on ultrasound examination and the detection of eggs in urine, however, diagnosis is often reached only through necropsy or histopathology. This study aimed to analyze the dog kidney anatomical and pathological changes when parasitized by Dioctophyme renale.Materials, Methods & Results: The kidneys of 21 dogs diagnosed with dioctophymiasis were nephrectomized, analyzed by ultrasound and forwarded to macro and microscopic analysis. Macroscopically, the kidney size was measured as well as its renal capsule thicknes. The presences of dilatation of the renal pelvis and ureter, as well as changes of the capsule, were also observed. These fragments were collected and submitted for routine analysis and stained with hematoxylin and eosin. Histopathological examination was performed blindly by three evaluators. The intensity of fibrosis was evaluated by the presence or absence of infiltration, the absence or presence of parasite eggs and when present whether there was inflammatory tissue response, among other changes. All received organs were right kidneys and showed clear atrophy or absence of the parenchyma. The kidney size ranged from 3,8x2,5x1,3 cm to 8,4x8,2x4,0 cm and the capsule thickness between 0.1 and 3.6cm. In renal capsule were observed whitish, irregular and firm plates (10 out of 21 cases) and papilliform projections (4 out of 21). In two specimens were identified cases of hydroureter and hydronephrosis. Microscopically, all specimens had some degree of fibrosis which replaced the renal parenchyma, six classified as mild, ten were moderate and five intense. In 13 cases there was intense deposition of parasite eggs and 18 cases showed inflammatory infiltrate of which one was pyogranulomatous and one granulomatous. Papilliform projections were observed in six out of 21 cases (composed of connective tissue proliferation and neovascularization), there was also hyperplasia of the pelvis transition epithelial (6 out of 21) and osseous metaplasia of the renal capsule (4 out of 21). The vessels walls were hypertrophic in nine out of 21 cases.Discussion: The diagnosis of dioctophymiasis was performed by ultrasonography. All 21 kidneys analyzed were rights; this is related to the parasite penetration in the duodenal wall, which tends to migrate by anatomic proximity to the right kidneys. Dioctophyme renale feeds through digestion and ingestion of the renal parenchyma by the action of parasite’s oesophageal enzymes causing progressive destruction of the cortical and medullar layers and consequently the proliferation of fibrous tissue. In this study, different intensities of fibrosis were observed. Bone metaplasia characterizes the chronicity of the process and the connective tissue’s attempt to adapt. Animals affected by dioctophymiasis often develop chronic renal failure. Chronic renal failure is characterized by continuous and irreversible morphologic changes in the renal parenchyma with loss of nephron components and the formation of a vicious cycle of replacement by fibrous connective tissue. The hypertrophy of vascular epithelium observed in six cases of this study may be associated with fibrous connective tissue proliferation stimulus. The injuries described here may be related to the parasitosis late diagnosis.

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Parasites in the urogenital tract of dogs and cats

Alam¹

2023

Organ-Specific Parasitic Diseases of Dogs and Cats

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Hallazgo de Dioctophyme renale en la cavidad torácica de un canino

Cited by 12 publications

References 2 publications

Alterações anatomopatológicas e parâmetros bioquímicos séricos e urinários em cães com diagnóstico de Dioctophyme renale

Alterações anatomopatológicas e parâmetros bioquímicos séricos e urinários em cães com diagnóstico de Dioctophyme renale

Anatomopathologic Study of Kidneys parasitized by Dioctophyme renale in Dogs

Parasites in the urogenital tract of dogs and cats

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