Halloysite nanotubes loaded with alkyl trimethyl ammonium bromide as antibacterial agent for root canal sealers

Monteiro, Juliana Caletti; García, Isadora Martini; Leitune, Vicente Castelo Branco; Visioli, Fernanda; Balbinot, Gabriela de Souza; Samuel, Susana Maria Werner; Makeeva, Irina; Collares, Fabrício Mezzomo; Sauro, Salvatore

doi:10.1016/j.dental.2019.02.018

Cited by 24 publications

(12 citation statements)

References 31 publications

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“…It is already well established that even after the root canal preparation for endodontic treatment with complete irrigation and shaping, there are still microorganisms on the root canal walls [45]. The improvement of the biological properties of root canal sealers has been studied to overcome this issue [46,47]. The dentinal tubule infection may lead to recurrent disease, determining endodontic retreatment [48].…”

Section: Discussionmentioning

confidence: 99%

Exploring Needle-Like Zinc Oxide Nanostructures for Improving Dental Resin Sealers: Design and Evaluation of Antibacterial, Physical and Chemical Properties

et al. 2020

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This study aimed to evaluate the effect of needle-like zinc oxide nanostructures (ZnO-NN) on the physical, chemical, and antibacterial properties of experimental methacrylate-based dental sealers. ZnO-NN was synthesized and characterized. ZnO-NN was added to a co-monomer blend at 20, 30, and 40 wt.%. One group without ZnO-NN was used as a control. The dental resin sealers were evaluated for their flow, film thickness, water sorption, solubility, radiopacity, degree of conversion (DC), dental-sealer interface characterization via micro-Raman, and antibacterial activity. ZnO-NN presented a mean needle diameter of 40 nm and 16 m2/g of surface area. There was no difference among groups containing ZnO-NN regarding their flow. The ZnO-NN addition significantly increased the film thickness. Water sorption and solubility tests showed no difference among groups. The radiopacity increased, and DC decreased with higher concentrations of ZnO-NN. Micro-Raman suggested that ZnO-NN was in close contact with root canal dentin. Overall, the incorporation of ZnO-NN provided an antibacterial effect against Enterococcus faecalis without a significant detrimental impact on the physical and chemical functionality of the material. The use of ZnO-NN as an inorganic filler is a potential application within dental materials intended for root canal treatment.

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Section: Discussionmentioning

confidence: 99%

Exploring Needle-Like Zinc Oxide Nanostructures for Improving Dental Resin Sealers: Design and Evaluation of Antibacterial, Physical and Chemical Properties

et al. 2020

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“…The parental composite resin formulated had its viscosity manually accessed for friendly use in clinical settings as a sealant. In the previous study with similar QAC, a high antibacterial effect of myristyltrimethylammonium bromide against Enterococcus faecalis was observed [27]. In both cases, these QACs have a long alkyl chain, which increases the QAC's hydrophobicity [38].…”

Section: Discussionmentioning

confidence: 87%

“…The main difference between MYTAB and ATAB is the presence of mixing of QACs with different aliphatic chain lengths for ATAB, which does not occur in the case of MYTAB. In the previous study, ATAB was associated with halloysite nanotubes (HNT) that were incorporated in the sealer without the evaluation of ATAB alone [27], which might have repercussions for physical, chemical, or biological properties. In the same study, there were no cytotoxic effects for pulp cells with the incorporation of 10 wt % of ATAB/ halloysite nanotubes in the sealer, even when the proportion of ATAB/ halloysite nanotubes was 2:1 [27].…”

Section: Discussionmentioning

confidence: 99%

“…In the previous study, ATAB was associated with halloysite nanotubes (HNT) that were incorporated in the sealer without the evaluation of ATAB alone [27], which might have repercussions for physical, chemical, or biological properties. In the same study, there were no cytotoxic effects for pulp cells with the incorporation of 10 wt % of ATAB/ halloysite nanotubes in the sealer, even when the proportion of ATAB/ halloysite nanotubes was 2:1 [27]. Here, MYTAB was not carried out by another system because we aimed to evaluate the QAC itself as a free drug, which may have increased the biological effects.…”

Section: Discussionmentioning

confidence: 99%

“…Trimethyl alkylammonium compounds such as the MYTAB series can also strongly affect bacterial membrane properties of a wide range of microorganisms, including changes in electrokinetic potential as well as net surface charge [26]. A recent study has shown promising application for the sealing of dental roots during endodontic treatment with expressive bacterial reduction of the endodontic pathogen [27]. Additionally, the long-chain MYTAB presents the potential to act as a useful endocytosis inhibitor for cell biology, inhibiting different forms of endocytosis in multiple cell systems [26].…”

Section: Introductionmentioning

confidence: 99%

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Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to Inhibit Streptococcus mutans Grown over Dental Resins: An In Vitro Study

Nunes

et al. 2020

JFB

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This in vitro study evaluated the effect of myristyltrimethylammonium bromide (MYTAB) on the physical, chemical, and biological properties of an experimental dental resin. The resin was formulated with dental dimetacrylate monomers and a photoinitiator/co-initiator system. MYTAB was added at 0.5 (G 0.5% ), 1 (G 1% ), and 2 (G 2% ) wt %, and one group remained without MYTAB and was used as the control (G Ctrl ). The resins were analyzed for the polymerization kinetics, degree of conversion, ultimate tensile strength (UTS), antibacterial activity against Streptococcus mutans, and cytotoxicity against human keratinocytes. Changes in the polymerization kinetics profiling were observed, and the degree of conversion ranged from 57.36% (±2.50%) for G 2% to 61.88% (±1.91%) for G 0.5% , without a statistically significant difference among groups (p > 0.05). The UTS values ranged from 32.85 (±6.08) MPa for G 0.5% to 35.12 (±5.74) MPa for G Ctrl (p > 0.05). MYTAB groups showed antibacterial activity against biofilm formation from 0.5 wt % (p < 0.05) and against planktonic bacteria from 1 wt % (p < 0.05). The higher the MYTAB concentration, the higher the cytotoxic effect, without differences between G Ctrl e G 0.5% (p > 0.05). In conclusion, the addition of 0.5 wt % of MYTAB did not alter the physical and chemical properties of the dental resin and provided antibacterial activity without cytotoxic effect.

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Alkyl trimethyl ammonium bromide for the formulation of antibacterial orthodontic resins

et al. 2022

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Halloysite nanotubes loaded with alkyl trimethyl ammonium bromide as antibacterial agent for root canal sealers

Cited by 24 publications

References 31 publications

Exploring Needle-Like Zinc Oxide Nanostructures for Improving Dental Resin Sealers: Design and Evaluation of Antibacterial, Physical and Chemical Properties

Exploring Needle-Like Zinc Oxide Nanostructures for Improving Dental Resin Sealers: Design and Evaluation of Antibacterial, Physical and Chemical Properties

Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to Inhibit Streptococcus mutans Grown over Dental Resins: An In Vitro Study

Alkyl trimethyl ammonium bromide for the formulation of antibacterial orthodontic resins

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