“…In the second section, a comprehensive comparative analysis and a hierarchy of the intermolecular interactions in all known relevant Fmoc-AA structures, as retrieved from the Cambridge Structural Database (CSD; Version 5.40, update February 2019; Groom et al, 2016) (see Schemes S1 and S2 in the supporting information), are considered. Generally, we divided privileged Fmoc-Tyr/ Phe derivatives into the following groups: A -containing a substituent O atom in the phenyl ring [(1), CAMLEK (Fichman et al, 2016), INEJEQ (Clegg & Elsegood, 2003), OGIYAG (Draper et al, 2015) and OGOGIA (Young & Kiessling, 2002)]; B -without substituents in the phenyl ring [OGIXOT, EKEWUM (Clegg & Elsegood, 2003), NUBPEH , OGIXUZ (Draper et al, 2015) and VERXUO (Rajbhandary et al, 2018)]; C -with an additional chain as substituent in the molecular backbone [MOXSUP (Scroggs et al, 2015) and DULLAZ (Wang et al, 2015)]; Dcontaining other substituents in the phenyl ring [UQIYUQ, UQOGUE (Liyanage & Nilsson, 2016) and WATSIU01 (Stefanowicz et al, 2006)]; E -including halogen atoms (XATJAG, XATJEK, XATKEL and XATKIP;Pizzi et al, 2017). Notably, OGOGIA, INEJEQ and EKEWUM possess a modified -COOH group.…”