Halsted Radical Mastectomy

Bland, Kirby I.; Klimberg, V. Suzanne; Copeland, Edward M.

doi:10.1016/b978-0-323-35955-9.00030-1

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…This is not a new idea as Paget first raised the concept in the context of breast cancer over a hundred years ago [ 6 ]. Both the early radical surgeries [ 7 ] and the focus on genetics in the twenty first century [ 8 ] represented huge advances in cancer management, but neglected the aforementioned crucial interplay. This interplay was also overlooked in the original concept of how metastases arose, which simply stated that cancer cells entered a one-way traffic flow to anatomically downstream organs (for example in axillary nodal spread of breast cancer).…”

Section: Seed and Soil Hypothesis And The Role Of Adhesion Moleculmentioning

confidence: 99%

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Rutherford

Hill

Hopkins

2018

Cells

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Although the developments in cellular and molecular biology over the last few decades have significantly advanced our understanding of the processes and players that regulate invasive disease, many areas of uncertainty remain. This review will discuss the contribution of dysregulated cell–cell and cell–matrix adhesion to the invasion in both benign and malignant contexts. Using the endometrium as an illustrative tissue that undergoes clinically significant invasion in both contexts, the adhesion considerations in the cells (“seed”) and their microenvironment (“soil”) will be discussed. We hope to orientate this discussion towards translational relevance for the diagnosis and treatment of endometrial conditions, which are currently associated with significant morbidity and mortality.

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Section: Seed and Soil Hypothesis And The Role Of Adhesion Moleculmentioning

confidence: 99%

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Rutherford

Hill

Hopkins

2018

Cells

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“…At the Johns Hopkins Hospital in Baltimore, it was popularised and scientifically used. In the past two decades, the development of less invasive mastectomies for the treatment of breast cancer has been monitored for effectiveness and equivalent results for locoregional management with conservative treatments followed by radiotherapy [4] . from being more aesthetically pleasing and less intrusive while yet keeping the natural breast tissue.…”

Section: Introductionmentioning

confidence: 99%

Rate of Conversion of Conservative Breast Surgery to Mastectomy in Patients with Early Breast Cancer Versus Late Breast Cancer after Down Staging

ISLAM K. HAMOUDA, M.Sc.; MOHAMED

2023

The Medical Journal of Cairo University

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Background: After lung cancer, breast cancer is the most frequent cancer among women and the second greatest cause of cancer death. Aim of Study:The rate and causes of breast conservative surgery conversion to mastectomy in early breast cancer versus down staging after neoadjuvant treatment are identified.Patients and Methods: During this study, 40 females with breast cancer were enrolled and divided into two groups. All patients were subjected to conservative breast surgery and intraoperative frozen section; 20 patients with early breast cancer andanother 20 patients who received neoadjuvant therapy. All patients were subjected to history taking, clinical examination, radiologic investigations, core biopsy, preoperative laboratory investigations and histopathological examination of excised mass.Results: There were no statistically significant differences between study groups as regard rate of conversion to mastectomy, frozen results, post-operative compilations and response and Clipping distribution. Conclusion:The rate of conversion to mastectomy, frozen results, post-operative compilations and response, and clipping distribution were similar in cases of early breast cancer and late stages subjected to neoadjuvant down staging treatment. As a result, all cases of late breast cancer were down staged using neoadjuvant therapy rather than undergoing mastectomy.

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Halsted Radical Mastectomy

Cited by 2 publications

References 36 publications

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Rate of Conversion of Conservative Breast Surgery to Mastectomy in Patients with Early Breast Cancer Versus Late Breast Cancer after Down Staging

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