Hamartoma combinado de retina y del epitelio pigmentario. Abordaje mediante terapia anti-VEGF de membranas neovasculares asociadas

Echevarría, L.; Villena, O.; Nievas, T.; Bellido, Rocío

doi:10.1016/j.oftal.2014.09.017

Cited by 9 publications

(6 citation statements)

References 8 publications

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“… 2 , 3 In all previously reported cases, CNVM secondary to CHRRPE occurs at the border of the lesion or underneath it. 3 , 10 , 11 , 12 To our knowledge, this is the first reported case of remote CNVM associated with CHRRPE. Owing to the elongated, circumferential orientation of the patient's lesion, tractional forces were exerted radially over a large area of retina leading to dragging of nasal retinal vessels, a dragged disc appearance, and a shallow tractional retinal detachment.…”

Section: Discussionmentioning

confidence: 68%

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Lazzarini¹,

Al-Khersan²,

Patel³

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To describe the first reported case of combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) associated with a remote choroidal neovascular membrane (CNVM). Observations A 19-month-old girl with a normal prenatal and infantile history presented with esotropia of the left eye. Fundus examination demonstrated a large, elevated, charcoal-colored lesion in the nasal equatorial retina. There was dragging of the nasal retinal vessels and a retinal fold, presumed to have resulted from nasal traction from the lesion. There was also subretinal hemorrhage in the peripapillary macula. Multimodal imaging demonstrated a peripapillary choroidal neovascular membrane (CNVM) underlying the retinal fold. There was no leakage within the tumor or secondary retinal neovascularization. Examination of the fellow eye was unremarkable. The patient was diagnosed with peripheral CHRRPE with associated peripapillary CNVM. She was treated with serial intravitreal bevacizumab to the affected eye which resulted in a reduction in leakage from the CNVM and resolution of the subretinal hemorrhage. The CHRRPE remained stable on follow-up. Conclusions Peripheral CHRRPE can rarely be associated with a remote CNVM.

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Section: Discussionmentioning

confidence: 68%

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Lazzarini¹,

Al-Khersan²,

Patel³

et al. 2020

American Journal of Ophthalmology Case Reports

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“…3 Kombine hamartom, periferik retinal iskemi ve sekonder periferik neovaskülarizasyon ile ilişkilendirilebilir. 27 alan "testere dişi" veya "katlanmış" retinayı ve vitreoretinal traksiyonu gösterir. 32 Gupta ve ark.…”

Section: Resimunclassified

Cysts and Tumors of the Retinal Pigment Epithelium

YOZGAT

2023

CRJ

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The iris, ciliary body and retinal pigment epithelium (RPE) can undergo reactive hyperplasia, but true neoplasms of the retinal pigment epithelium are rare. RPE tumors can be benign or malignant. Even malignant variants rarely metastasize locally or distantly. Recognition of RPE tumors is important as they can be clinically confused with uveal melanomas and the prognosis and treatment of these two conditions are completely different. They can be distinguished from melanoma by their clinical, imaging and cytopathological features. While observation is usually sufficient in small and asymptomatic RPE tumors, more aggressive treatments (vitreoretinal surgery, plaque radiotherapy, etc.) may be required depending on the conditions they rarely cause. In this review, it is aimed to convey current literature information under 8 sub-titles by quoting references from relatively new diagnostic tests and researches on the subject.

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“…While combined hamartoma is a benign tumor, macular edema and choroidal neovascularization (CNV) can occur in association with these lesions, which can lead to a poor visual outcome [26]. Treatment of CNV in the past has included photodynamic therapy and laser photocoagulation but, more recently, intravitreal antiangiogenic injections have been utilized [27, 28]. …”

Section: Case Presentationmentioning

confidence: 99%

Multimodal imaging of combined hamartoma of the retina and retinal pigment epithelium associated with an acquired vitelliform lesion

et al. 2015

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BackgroundWe present a case of a combined hamartoma of the retina and retinal pigment epithelium associated with a subfoveal acquired vitelliform lesion induced by vitreomacular traction. The purpose of this report is to present a unifying hypothesis of these concurrent findings, as aided by multimodal imaging.Case PresentationA 25-year-old white man presented with a 6-month history of a visual disturbance in his left eye. At presentation, ophthalmic assessment showed a combined hamartoma adjacent to his optic nerve that had caused marked corrugation within the inner retinal surface. An acquired vitelliform lesion was present in the macula with an associated epiretinal membrane as demonstrated on spectral-domain optical coherence tomography. Optical coherence tomography angiography corroborated the clinical diagnosis of combined hamartoma.ConclusionsWe are not aware of previous cases of a combined hamartoma associated with an acquired vitelliform lesion. As previously proposed in acquired vitelliform lesions related to epiretinal membrane and vitreoretinal traction, we believe that macular tractional forces might interfere with retinal pigment epithelium phagocytosis of shed outer segments, leading to the occurrence of this acquired vitelliform lesion.

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Hamartoma combinado de retina y del epitelio pigmentario. Abordaje mediante terapia anti-VEGF de membranas neovasculares asociadas

Cited by 9 publications

References 8 publications

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Cysts and Tumors of the Retinal Pigment Epithelium

Multimodal imaging of combined hamartoma of the retina and retinal pigment epithelium associated with an acquired vitelliform lesion

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