Hämophilie-A-Patienten und Konduktorinnen für Hämophilie A

Haferland, I.; Scholz, K. H.; Asmelash, G.; Makki, V.; Sa, Müller; Krekeler, S.; Alesci, S.; Miesbach, Wolfgang

doi:10.1055/s-0037-1619745

Cited by 2 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, patients with mild hemophilia A have been shown to have increasing levels of FVIII over time. 35 Furthermore, also age-adjusted D-dimer cutoff values have been established. 36 However, with respect to the determination of geriatric RIs, it appears to be difficult to differentiate the effects of age and (general) pathological conditions in the elderly.…”

Section: Age- and Pregnancy-dependent Reference Intervals And Biologi...mentioning

confidence: 99%

Reference Intervals in Coagulation Analysis

et al. 2022

View full text Add to dashboard Cite

Blood coagulation analysis is characterized by the application of a variety of materials, reagents, and analyzers for the determination of the same parameter, or analyte, by different laboratories worldwide. Accordingly, the application of common reference intervals, that, by definition, would represent a “range of values (of a certain analyte) that is deemed normal for a physiological measurement in healthy persons,” is difficult to implement without harmonization of procedures. In fact, assay-specific reference intervals are usually established to allow for the discrimination of normal and abnormal values during evaluation of patient results. While such assay-specific reference intervals are often determined by assay manufacturers and subsequently adopted by customer laboratories, verification of transferred values is still mandatory to confirm applicability on site. The same is true for reference intervals that have been adopted from other laboratories, published information, or determined by indirect data mining approaches. In case transferable reference intervals are not available for a specific assay, a direct recruiting approach may or needs to be applied. In comparison to transferred reference interval verification, however, the direct recruiting approach requires a significantly higher number of well-defined samples to be collected and analyzed. In the present review, we aim to give an overview on the above-mentioned aspects and procedures, also with respect to relevant standards, regulations, guidelines, but also challenges for both, assay manufacturers and coagulation laboratories.

show abstract

Section: Age- and Pregnancy-dependent Reference Intervals And Biologi...mentioning

confidence: 99%

Reference Intervals in Coagulation Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

Influence of blood group, von Willebrand factor levels, and age on factor VIII levels in non‐severe haemophilia A

Rejtő

Königsbrügge

Grilz

et al. 2020

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Data on the effect of ABO blood group (ABO), von Willebrand factor (VWF) levels, and age on factor VIII (FVIII) in non-severe haemophilia A (HA) is scarce.Objective: To investigate if ABO, VWF levels, and age have an influence on the variability of FVIII levels and consequently on the assessment of severity in non-severe HA. Patients/Methods: Eighty-nine patients with non-severe HA and 82 healthy controls were included. Data on ABO was collected and FVIII clotting activity (FVIII:C) with onestage clotting assay (FVIII:C OSA) and chromogenic substrate assay (FVIII:C CSA), FVIII antigen (FVIII:Ag) and VWF antigen (VWF:Ag) and activity (VWF:Act) were determined. Results: In HA, FVIII:C OSA and CSA and FVIII:Ag were not different between non-O (n = 42, median 15.5, interquartile range 10.4-24.0; 10.0, 6.8-26.0 and 15.2, 10.7-24.9)and O (n = 47, 14.1, 9.0-23.0; 10.0, 5.0-23.0 and 15.2, 9.3-35.5), whereas in healthy controls, non-O individuals had significantly higher FVIII levels. FVIII:C showed no relevant correlation with VWF levels in HA, but we observed strong correlations in healthy controls. Age had only a minor influence in HA, but had a considerable impact on FVIII:C in healthy controls. In multivariable regression analysis ABO, VWF:Ag and age were not associated with FVIII:C in HA, whereas this model explained 61.3% of the FVIII:C variance in healthy controls. Conclusions:We conclude that in non-severe HA ABO and VWF levels do not substantially influence the variability of FVIII levels and age has only minor effects on it, which is important information for diagnostic procedures.

show abstract

Hämophilie-A-Patienten und Konduktorinnen für Hämophilie A

Cited by 2 publications

References 17 publications

Reference Intervals in Coagulation Analysis

Reference Intervals in Coagulation Analysis

Influence of blood group, von Willebrand factor levels, and age on factor VIII levels in non‐severe haemophilia A

Contact Info

Product

Resources

About