Hand, foot, and mouth disease: Identifying and managing an acute viral syndrome

Repass, Gregory L; Palmer, William C.; Stancampiano, Fernando

doi:10.3949/ccjm.81a.13132

Cited by 91 publications

(86 citation statements)

References 16 publications

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“…İlk kez 1957 yılında Yeni Zelanda'dan tanımlanmıştır 1 . Etkeni Picornaviridae ailesinden Echovirus, Coxsackievirus A5, A7, A9, A10, B2, B5, A16 ve Enterovirus 71, 72 olarak bildirilmektedir 2 . Tipik klinik bulguları, kısa bir prodromal evre sonrasında görülen eroziv stomatit ile avuç içi ve ayak tabanlarında eritemli papüloveziküler lezyonlardır 3 .…”

Section: Introductionunclassified

“…Hafif ve kendini sınırlayan bir hastalık olmakla birlikte; aseptik menenjit, ensefalit, miyokardit, pulmoner ödem ve/veya hemoraji, plevral effüzyon, akut flask paralizi ve dehidratasyon gibi komplikasyonlara da rastlanabilmektedir 3 . Literatürde EAAH'nin 1998'de Tayvan'da, 2008'de Singapur ve Vietnam'da, 2008-2013 yılları arasında ise Çin'de büyük salgınlara neden olduğu bildirilmiştir 2,5,6 . Ülkemizde ise Polat Ekinci ve ark.…”

Section: Introductionunclassified

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Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Bucak¹,

Tepe²,

Almış³

et al. 2017

TURKDERM

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Background and Design: Hand, foot and mouth disease (HFMD) is a childhood enteroviral eruptive disease presenting with fever and cutaneous and mucosal lesions. It is benign and generally resolves spontaneously, but may sometimes result in systemic involvement. The purpose of this study was to share our clinical experience concerning patients who were followed with the diagnosis of HFMD established by the pediatric and dermatology clinics. Materials and Methods: We prospectively evaluated patients who attended our hospital with the complaints of fever and eruptions and received the diagnosis of HFMD based on the clinical findings between December 2014 and November 2015. Age, sex, month of presentation, presentation symptoms and duration of symptoms were investigated. Systemic and dermatological examination findings, laboratory results and tests such as echocardiography were reviewed. Results: Thirty-nine patients were included; 19 (48.8%) were girl and 20 (51.2%) were boy. The mean age of the patients was 29.8±27.9 (6-155) months. Six (15.3%) patients were in the 0-12 month age group, while only 3 (7.8%) were older than 60 months. Presentations were most common in September, June and October. The most common presentation symptoms were eruptions on the hands and feet (100%), fever (82.1%) and oral aphthae (79.5%). The lesions were most commonly observed on the hands (94.9%, n=37) and feet (87.2%, n=34) and in the mouth (79.5%, n=31). Cardiac involvement was determined in 3 (7.7%) patients. Nail changes were observed during monitoring in 10 (25.6%) patients. AbstractAmaç: El-ayak-ağız hastalığı (EAAH); ateş, deri ve mukoza lezyonları ile seyreden, çocukluk çağının enteroviral döküntülü bir hastalığıdır. İyi seyirli ve kendiliğinden düzelme eğiliminde olmakla birlikte, nadiren sistemik tutuluma yol açabilir. Bu çalışmanın amacı, pediatri ve dermatoloji klinikleri tarafından EAAH tanısıyla takip edilen hastalara ait klinik deneyimlerimizi paylaşmaktır. Gereç ve Yöntem: Hastanemize Aralık 2014-Kasım 2015 tarihleri arasında ateş ve döküntü şikayeti ile başvuran hastalardan, klinik bulgulara dayanılarak EAAH tanısı koyulan hastalar prospektif olarak değerlendirildi. Hastaların yaşı, cinsiyeti, başvuru ayı, başvuru şikayeti ve süresi sorgulandı. Sistemik ve dermatolojik muayene bulguları, laboratuvar sonuçları, ekokardiyografi gibi ek inceleme tetkikleri gözden geçirildi. Bulgular: Çalışmaya toplam 39 hasta dahil edildi. Hastaların 19'u (%48,8) kız, 20'si (%51,2) erkek idi. Hastaların ortalama yaşı 29,8±27,9 (6-155) ay olarak hesaplandı. Yaş aralığına göre hastaların 6'sı (%15,3) 0-12 ay arasında iken, sadece 3'ü (%7,8) 60 aydan büyüktü. Başvurular en sık Eylül, Haziran ve Ekim aylarında görüldü. En sık başvuru şikayeti; el ve ayaklarda döküntü (%100), ateş (%82,1) ve oral aft (%79,5) idi. Lezyonlar, en sık el (%94,9, n=37), ayak (%87,2, n=34) ve ağız içinde (%79,5, n=31) görüldü. Üç hastada (%7,7) kardiyak tutulum saptandı. Takiplerde 10 hastada (%25,6) tırnak değişikliği gelişti. Sonuç: Çalışmamız sonucunda ülkemizde E...

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Section: Introductionunclassified

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Bucak¹,

Tepe²,

Almış³

et al. 2017

TURKDERM

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show abstract

“…A number of enteroviruses can cause hand, foot, and mouth disease (HFMD), which is a common infectious disease in young children (Bian et al, 2015;Mao et al, 2014;Repass et al, 2014;Wong et al, 2010;Xing et al, 2014). Among these enteroviruses, enterovirus 71 (EV71) and coxsackievirus A16 (CA16) had been responsible for majority of the HFMD outbreaks before 2008 (Mao et al, 2014;Wong et al, 2010) and therefore have been targeted for vaccine development (Chong et al, 2015;Klein, 2015;Liu et al, 2014Liu et al, , 2015Mao et al, 2014).…”

mentioning

confidence: 99%

Yeast-produced recombinant virus-like particles of coxsackievirus A6 elicited protective antibodies in mice

et al. 2016

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“…Hand-foot-month disease is a common acute infectious disease in the department of pediatrics in clinic, the relevant data showed the morbidity and mortality of hand-foot-mouth disease are rising, which has already become the one of important public health issues [13]. Currently, a lot of clinical studies proved that the ribavirin could be used in the treatment of hand-foot-mouth disease, which also could inhibit the inosine 5-monophosphate dehydrogenase, prevent the inosine turning into guanylic acid, and the virus DNA, RNA replication, which have the favorable inactivation and cause less harm to body [9,14].…”

Section: Discussionmentioning

confidence: 99%

Analysis of effect on tanreqing injection combined with ribavirin on children with hand-foot-mouth disease complicated with pneumonia and its influence on serum inflammatory factors

Yu¹,

Lu²,

Yu³

2018

biomedicalresearch

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Objective: To investigate the efficacy of tanreqing injection combined with Ribavirin for hand-footmouth disease complicated with pneumonia and its influence on serum inflammatory factors. Methods: 72 children with hand-foot-mouth disease complicated with bronchopneumonia were recruited from January 2016 to June 2017 in our hospital, and randomly divided into observation group (n=36) and control group (n=36). The control group was treated with ribavirin injection, and the observation group was treated with tanreqing injection on the basis of the control group. The time of symptoms and signs improvement, and the changes of Interleukin-2 (IL-2), Interleukin-6 (IL-6), Interleukin-10 (IL-10), C-Reactive Protein (CRP) and Tumor Necrosis Factor-α (TNF-α) were compared between the two groups. Results: The time of pyretolysis, rash subsided, oral mucosal congestion, disappearance of cough and rales in the observation group were significantly less than those in the control group (t=9.667, 4.577, 7.526, 3.651, 5.677, all P<0.05); after treatment, the levels of IL-2, IL-6 and IL-10 in the two groups were significantly decreased (t=6.773, 6.164, 7.581, 2.781, 2.434, 3.023, all P>0.05), and the above indexes in the observation group were significantly lower than those in the control group (t=5.415, 4.616, 4.365, all P<0.05); after treatment, the levels of CRP and TNF-α in the two groups were significantly decreased (t=13.486, 40.914, 14.136, 32.922, all P<0.05), and the above indexes in the observation group were significantly lower than those in the control group (t=16.619, 23.077, all P<0.05). Conclusion: Tanreqing injection combined with ribavirin can effectively promote the rehabilitation of hand-foot-mouth disease complicated with pneumonia, and reduce the levels of inflammatory factors in serum.

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Hand, foot, and mouth disease: Identifying and managing an acute viral syndrome

Cited by 91 publications

References 16 publications

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Yeast-produced recombinant virus-like particles of coxsackievirus A6 elicited protective antibodies in mice

Analysis of effect on tanreqing injection combined with ribavirin on children with hand-foot-mouth disease complicated with pneumonia and its influence on serum inflammatory factors

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