2018
DOI: 10.1016/j.pacs.2018.07.001
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Hand-held optoacoustic imaging: A review

Abstract: Optoacoustic imaging is a medical imaging modality that uses optical excitation and acoustic detection to generate images of tissue structures based up optical absorption within a tissue sample. This imaging modality has been widely explored as a tool for a number of clinical applications, including cancer diagnosis and wound healing tracking. Recently, the optoacoustic imaging community has published a number of reports of hand-held optoacoustic imaging devices and platforms; these hand-held configurations im… Show more

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Cited by 127 publications
(96 citation statements)
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References 111 publications
(301 reference statements)
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“…Compared to traditional fluorescence imaging systems, the key difference of MSOT is that its ability to use light for excitation and sound for detection enables a greater penetration depth. The development of optoacoustic imaging tools for diabetes is a valuable but unmet clinical need 7,8,25,31,43 . A handful of proof-of-concept studies in the literature have emerged to show the potential of diabetes monitoring via optoacoustic imaging, but none feature direct visualizations of ß-cells 6-9, 19, 44-46 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Compared to traditional fluorescence imaging systems, the key difference of MSOT is that its ability to use light for excitation and sound for detection enables a greater penetration depth. The development of optoacoustic imaging tools for diabetes is a valuable but unmet clinical need 7,8,25,31,43 . A handful of proof-of-concept studies in the literature have emerged to show the potential of diabetes monitoring via optoacoustic imaging, but none feature direct visualizations of ß-cells 6-9, 19, 44-46 .…”
Section: Discussionmentioning
confidence: 99%
“…BCM need a reliable method for non-invasive in vivo imaging and quantification 28,29 . A handful of suitable and clinically translatable two-dimensional (2D) and three-dimensional (3D) hand-held optoacoustic devices exists 30,31 , including commercial options for clinical research [32][33][34] . Based on previous approaches and motivated by the undeniable clinical need to non-invasively resolve ß-cells mass in vivo, we explored the use of exendin as a targeted vector using multi-spectral optoacoustic tomography (MSOT), a preclinical optoacoustic platform, similar to the equipment used in the clinics.…”
Section: Introductionmentioning
confidence: 99%
“…PA imaging has high contrast and can provide spectroscopic information, while ultrasound can provide morphological and anatomical information about the surrounding tissues and structures. Thus, numerous systems combining PA imaging with conventional B-mode ultrasound (US) imaging were proposed (e.g., [84,[105][106][107][108][109][110][111][112][113]) and some integrated PAUS systems are commercially available (e.g., Fujifilm VisualSonics Vevo LAZR or Seno Medical Instruments Imagio). LUI may be advantageous, since it may use the same laser pulse to generate the probe pulse and the bandwidth of the probe pulse may be wider (from 1 to 10 MHz).…”
Section: Combined Pa and Lu Pulse-echo Imagingmentioning
confidence: 99%
“…In den letzten Jahren wurden eine Reihe verschiedener optoakustischer Modalitäten hinsichtlich ihres Potenzials für einen Einsatz in der Klinik in verschiedenen Fachrichtungen insbesondere der Dermatologie untersucht. [5] Im Folgenden gehen wir auf die technischen Grundlagen sowie einzelne Anwendungen in der Makro-, Meso-und Mikroskopie näher ein.…”
Section: Introductionunclassified