Handbook of Liquid Crystals

Kelker, H.; Hatz, R.; Schümann, Christian

doi:10.1002/9783527671403

Cited by 406 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be due to partial insertion of the bulky stealthy lipids into the ordered stacks. The peak width, indicating the correlation length, ξ, (see the Methods section, eq ), increased slightly, and therefore the correlation length slightly decreased.…”

Section: Resultsmentioning

confidence: 99%

Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery

Nogueira

Schlegel

Maxeiner

et al. 2020

ACS Appl. Nano Mater.

154

126

View full text Add to dashboard Cite

Polysarcosine (pSar) is a polypeptoid based on the endogenous amino acid sarcosine (N-methylated glycine), which has previously shown potent stealth properties. Here, lipid nanoparticles (LNPs) for therapeutic application of messenger RNA were assembled using pSarcosinylated lipids as a tool for particle engineering. Using pSar lipids with different polymeric chain lengths and molar fractions enabled the control of the physicochemical characteristics of the LNPs, such as particle size, morphology, and internal structure. In combination with a suited ionizable lipid, LNPs were assembled, which displayed high RNA transfection potency with an improved safety profile after intravenous injection. Notably, a higher protein secretion with a reduced immunostimulatory response was observed when compared to systems based on polyethylene glycol (PEG) lipids. pSarcosinylated nanocarriers showed a lower proinflammatory cytokine secretion and reduced complement activation compared to PEGylated LNPs. In summary, the described pSar-based LNPs enable safe and potent delivery of mRNA, thus signifying an excellent basis for the development of PEG-free RNA therapeutics.

show abstract

Section: Resultsmentioning

confidence: 99%

Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery

Nogueira

Schlegel

Maxeiner

et al. 2020

ACS Appl. Nano Mater.

154

126

View full text Add to dashboard Cite

show abstract

“…Perylene bisimides (PBIs) have received considerable attention for their excellent chemical/thermal stability, facile molecular design, and outstanding optical and electronic properties, which are of paramount importance in their applications as various optoelectronic devices. − Incorporation of PBIs in liquid crystals (LCs) beautifully demonstrates their general organization principle , and facilitates better processability than that of highly crystalline materials due to their dynamic reorganization ability. − In general, the large planar aromatic core of PBI tends to π–π-stack cofacially into discotic columnar LCs, which has led to their implementation in semiconductor-related devices. ,,− Despite the fluorescence quantum yield (Φ F ) of PBIs ranging up to unity in dilute solutions, almost all PBI-based LCs are nonfluorescent in the solid state due to their close π–π stacking, which provides a pathway for nonradiative decay to quench the emission. − Conversely, the advantageous combination of intrinsic light emission and unique self-organization properties of luminescent LCs − has facilitated advanced applications such as anisotropic displays, polarized emissions, − and multichromic fluorescence materials. − Thus, it is of significance but remains a challenge to overcome the prevailing fluorescence quenching pathways for constructing PBI-based luminescent LC materials.…”

Section: Introductionmentioning

confidence: 99%

Perylene Bisimide-Based Luminescent Liquid Crystals with Tunable Solid-State Light Emission

Zhang

Quan

et al. 2021

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Perylene bisimides are among the most studied building blocks for supramolecular assemblies in the fabrication of optoelectronic devices for their exceptional optical and electronic properties; however, developing perylene bisimide-based luminescent liquid crystals remains a challenge for the strong π-stacking tendency of the large planar aromatic core to quench the emission. We here reported a novel strategy to achieve luminescent liquid crystals based on perylene bisimides by introducing a conformation-adjustable core to control the molecular stacking arrangement of planar perylene bisimides in the solid state. The emission wavelength is in the deep-red region with a luminescence efficiency of up to 10%. Fluorescence properties of the liquid crystals can be further regulated by photoisomerization-induced structural evolution from columnar to lamellar mesophases. These luminescent liquid crystals are also able to not only exhibit strong emission at high temperatures but also show attractive thermochromic luminescence tuning behaviors. This work provides a new strategy for the design and development of novel solid-state luminescent materials with potential for various optoelectronic applications.

show abstract

“…The design of new materials possessing novel architectures represents an important area of our interests in geometrical approaches (Yagai and Kitamura, 2008;Yeap et al, 2009;Hagar et al, 2019). Recently, many researchers (Paleos and Tsiourvas, 2001;Armstrong and Buggy, 2005;Tschierske, 2013;Goodby et al, 2014;Ahmed and Naoum, 2016;Ahmed et al, 2018a,b;Ahmed et al, 2019b;Saccone et al, 2019;Tuchband et al, 2019;Martinez-Felipe et al, 2020;Walker et al, 2020) have investigated the mesophase behavior of new SMHBCs between the carboxylic acid group and pyridine-containing compounds (Al-Mutabagani et al, 2020;Nafee et al, 2020). These studies were focused on the correlation between the mesomorphic transition data and the evaluated computational calculations for SMHBCs.…”

Section: Introductionmentioning

confidence: 99%

Experimental and Computational Approaches of Newly Polymorphic Supramolecular H-Bonded Liquid Crystal Complexes

et al. 2020

View full text Add to dashboard Cite

New 1:2 liquid crystalline supramolecular H-bonded complexes (SMHBCs) were synthesized through double H-bond interactions between 4-(nicotinoyloxy) phenyl nicotinate as the base component and two molecules of 4-n-alkoxybenzoic acid (An). The base component was expected to be in two conformers according to the orientation of the N atom and the carboxylate group, syn conformer (I) and anti-conformer (II). DFT calculations revealed that only one of the two possible conformers of I exists, and the addition of the two molecules of the alkoxy acids (An) did not affect its conformation. The mesomorphic properties of all of the prepared complexes (I/An), bearing different terminal flexible alkoxy chains were investigated, and the formation of the H-bonds were confirmed by differential scanning calorimetry (DSC), and the phases were identified by polarized optical microscopy (POM), and FT-IR spectroscopy. Highly thermally stable mesophases possessing broad temperature ranges were observed for all investigated complexes compared to their individual components. Depending on the length of the terminal flexible alkoxy chain, the prepared SMHBCs were shown to exhibit di-or tri-morphic enantiotropic mesophases. The effect of replacing one of the-COO-connecting units by an azo group (-N=N-) in the basic molecule (I), on the mesomorphic properties has been investigated experimentally (via DSC) and theoretically (via DFT). The DFT calculations revealed that the polarizability, the dipole moment, and the aspect ratio of the investigated SMHBCs are lower than those of their corresponding ester/azo analogs. All these factors rationalize the enhanced smectic mesophase ranges of the complexes compared with those of the ester/azo analogs. The high aspect ratios and dipole moments of the SMHBCs of the azo derivative enforces the lateral intermolecular attraction that permits the formation of the more ordered smectic C mesophase with respect to the enhanced polymorphic mesophases of the diester derivative.

show abstract

Handbook of Liquid Crystals

Cited by 406 publications

References 0 publications

Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery

Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery

Perylene Bisimide-Based Luminescent Liquid Crystals with Tunable Solid-State Light Emission

Experimental and Computational Approaches of Newly Polymorphic Supramolecular H-Bonded Liquid Crystal Complexes

Contact Info

Product

Resources

About