Handedness in Psychiatric Patients

Fleminger, J. J.; Dalton, Rosemary; Standage, Kevin

doi:10.1192/bjp.131.5.448

Cited by 61 publications

(19 citation statements)

References 19 publications

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“…Increased NRH in SZ seems established (Hirnstein and Hugdahl, 2014), but research on differences between BPD and both SZ and HC, and the specificity of differences to BPD with psychotic features, is limited. Studies comparing NRH between SZ and affective psychosis often combined patients with BPD and depression, (Fleminger et al, 1977; Malesu et al, 1996), whereas studies comparing NRH between SZ and BPD did not clearly differentiate between BPD with and without psychosis (Clementz et al, 1994; Yan et al, 1985). These studies yielded inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Frequency of non-right-handedness in bipolar disorder and schizophrenia

Ravichandran

Shinn

Öngür

et al. 2017

Psychiatry Research

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Increased non-right-handedness (NRH) probably reflects neurodevelopmental abnormalities in psychiatric disorders. Past studies of NRH have focused more on schizophrenia (SZ) than bipolar disorder (BPD). We report results on NRH in two large studies. In (1), NRH was compared among BPD patients with psychosis, SZ patients, and healthy controls (HC). NRH was elevated in BPD with psychosis and SZ patients relative to HC, but not SZ relative to BPD. In (2), NRH was compared between BPD patients with and without psychosis. NRH was similarly elevated in both. The findings suggest that NRH may reflect shared brain anomalies in SZ and BPD.

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Section: Introductionmentioning

confidence: 99%

Frequency of non-right-handedness in bipolar disorder and schizophrenia

Ravichandran

Shinn

Öngür

et al. 2017

Psychiatry Research

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“…The overall effect of a pathological process affecting lateralization in a certain group of individuals would therefore be a shift away from dextrality to nonright-handedness. Several studies of handedness and schizophrenia using a dichotomous classification have found that schizophrenic patients have an increased rate of non-right-handedness (20%) compared with normal subjects [10][11][12][13][14] with two exceptions [15,16], who found an excess of dextrality. Using a broader category of 'nonright-handedness' in schizophrenia, different studies found an association between schizophrenia and non-right-handedness but no increase in pure left-handedness [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Non-Right-Handedness and Obstetrical Complications in Paranoid Hallucinatory Schizophrenics

Sperling

Martus²,

Barocka³

1999

Psychopathology

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In previous studies a link between pregnancy complications, minor physical anomalies and non-right-handedness was described in schizophrenic patients. There is evidence of an anomaly in the lateralization process in schizophrenia. Many studies of handedness and schizophrenia have found that schizophrenic patients have an increased rate of non-right-handedness compared with normal subjects. The contemporary neurodevelopmental hypothesis of schizophrenia emerged from pathobiological findings. In addition there is evidence for early brain lesions and malformations in fetal brain development. Especially pregnancy and birth complications have been found to be a risk factor for the later development of schizophrenia. In this study we set out to test the possible association between diagnosis and handedness, diagnosis and risk factors, as well as gender and handedness for 60 patients (30 men, 30 women) and 60 controls. The percentage of non-right-handedness was significantly elevated in the patient group (p = 0.0025). In a gender-specific analysis this result could be confirmed only for male patients. Peri- and postnatal developmental risk factors were significantly elevated in schizophrenics compared with controls. The percentage of all risk factors in the male group of schizophrenic non-right-handers was significantly elevated compared with right-handed male schizophrenics.

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“…Examining sex differences in patients' motor asymmetries, together with reports of sex differences in similar types of measures in animals (Fleminger et al 1977;Robinson et al 1980;Brass and Glick 1981;Ross et al 1981;Manoach 1994), supports the view that gonadal hormones may play an important role in the prenatal development and adult expressions of lateralized motor functions in schizophrenia. As mentioned above, research in animals shows that motor asymmetries in males and females are differentially affected by exposure to a variety of factors during early development Camp et al 1984;Alonso et al 1991).…”

Section: Laterality In Animals and In Schizophrenia Patientsmentioning

confidence: 80%

“…Lateralized disturbances in patients with schizophrenia have been noted at many levels of behavioral analysis (Nasrallah 1986). Some early studies of anomalous laterality found disturbances in basic cognitive, perceptual, and motor behaviors (Flor-Henry 1976;Gur 1977Gur , 1978Gruzelier and Hammond 1979), in addition to evidence for abnormal distributions of hand preference in schizophrenia populations (Boklage 1977;Fleminger et al 1977). These studies laid the groundwork for exploration into the sensory (Carr et al 1992;Mathew et al 1993), motor (Bracha 1987Gorynia and Uebelhack 1992;Lohr and Caligiuri 1995;Sakuma et al 1996), attentional (Posner et al 1988;Tomer and Flor-Henry 1989;Harvey et al 1993;Carter et al 1994;Bustillo et al 1997;Evans and Schwartz 1997), and cognitive manifestations (Saykin et al 1991(Saykin et al , 1994Green et al 1994;Haut et al 1996;Sakuma et al 1996) of behavioral asymmetry that have continued to demonstrate striking differences between patients with schizophrenia and normal controls.…”

Section: Laterality In Animals and In Schizophrenia Patientsmentioning

confidence: 99%

“…For example, various studies of hand preference have shown patients with schizophrenia to have higher, lower, or equal percentages of non-right-handedness as compared with controls (Boklage 1977;Fleminger et al 1977;Taylor et al 1980;Torrey et al 1993;Cannon et al 1995;Sakuma et al 1996) and patients with bipolar disorder (Lohr and Caligiuri 1995). The direction and degree of various motor asymmetries have been shown to vary as a function of clinical subgroup, severity of illness, family history of psychosis, and sex (Fleminger et al 1977;Manoach 1994;Cannon et al 1995;Tyler et al 1995). In general, findings support the view of Nasrallah (1986, p. 160), who theorized that "inconsistent findings in handedness research in schizophrenia may in large part be due to the different subtype and gender compositions of the various samples reported."…”

Section: Laterality In Animals and In Schizophrenia Patientsmentioning

confidence: 99%

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Laterality in Animals: Relevance to Schizophrenia

Cowell

Fitch

Denenberg

1999

Schizophrenia Bulletin

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Anomalies in the laterality of numerous newocognitive dimensions associated with schizophrenia have been documented, but their role in the etiology and early development of the disorder remain unclear. In the study of normative neurobehavioral organization, animal models have shed much light on the mechanisms underlying and the factors affecting adult patterns of both functional and structural asymmetry. Nonhuman species have more recently been used to investigate the environmental, genetic, and neuroendocrine factors associated with developmental language disorders in humans. We propose that the animal models used to study the basis of lateralization in normative development and language disorders such as dyslexia could be modified to investigate lateralized phenomena in schizophrenia.Key words: Animal models, laterality in animals, functional and structural asymmetry, language, hand preference.Schizophrenia Bulletin, 25(l):41-62,1999.Throughout the history of the brain and behavioral sciences, it has been largely accepted that cerebral lateralization was a unique feature of the human brain, particularly for functions underlying language and hand preference (Glick et al. 1979;MacNeilage et al. 1987; Denenberg 1988). However, accumulated evidence now supports the existence of lateralization at the structural and functional levels in a range of species. A portion of the literature on animal laterality will be discussed in this article, but the reader is referred to a number of recent, comprehensive reviews for more detailed coverage of functional, anatomical, and neurochemical asymmetries in nonhuman species (Denenberg 1984; Diamond 1984;Gerendai 1984;Goldman-Rakic and Rakic 1984; Bianki 1988;Springer and Deutsch 1989;Ward 1991;Hellige 1993;Hiscock and Kinsbourne 1995).Despite the large and growing literature describing behavioral, neuroanatomical, and neurophysiological asymmetries in nonhuman species, research on animal laterality has not been well integrated into the mainstream of human brain research. Nevertheless, a few investigators have demonstrated success in applying animal models of laterality to the study of human brain development and behavioral disorders. For example, Denenberg, Fitch, Rosen, and colleagues have used rodents to model the anomalous laterality patterns associated with developmental dyslexia and language impairment (Rosen et al.

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Handedness in Psychiatric Patients

Cited by 61 publications

References 19 publications

Frequency of non-right-handedness in bipolar disorder and schizophrenia

Frequency of non-right-handedness in bipolar disorder and schizophrenia

Non-Right-Handedness and Obstetrical Complications in Paranoid Hallucinatory Schizophrenics

Laterality in Animals: Relevance to Schizophrenia

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