Handgrip strength and weight predict long-term mortality in acute kidney injury patients

Xavier, Santos; Góes, Cassiana Regina de; Bufarah, Marina Nogueira Berbel; Balbi, André Luís; Ponce, Daniela

doi:10.1016/j.clnesp.2016.09.006

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…In separate models examining incident CKD, CKD progression and mortality, there was also no detectable modifying effect of BMI on the primary study finding that AKI is independently associated with a higher risk of the development of CKD, CKD progression, and mortality with up to 8 y of follow-up. Several studies have examined the effect of BMI on mortality after AKI over the short term, although these were retrospective [ 18 , 19 , 37 ] or prospective with no comparator group [ 17 , 38 ]. Some studies show that up to 6 months post AKI, higher BMI is protective against mortality, compared to lower BMI [ 17 – 19 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have examined the effect of BMI on mortality after AKI over the short term, although these were retrospective [ 18 , 19 , 37 ] or prospective with no comparator group [ 17 , 38 ]. Some studies show that up to 6 months post AKI, higher BMI is protective against mortality, compared to lower BMI [ 17 – 19 , 38 ]. Our findings concur with the largest study prospective study, which found that high body mass index (BMI) did not modify the risk of mortality 1-year post discharge in a cohort of patients with AKI admitted to critical care, compared to those without AKI [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study

et al. 2021

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Background Acute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI. Methods This prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event of incident CKD, progression of CKD and kidney failure, examined using time-to-event Cox proportional hazards models, adjusted for diabetes status, age, pre-existing CKD, cardiovascular disease status and intensive care unit admission, and stratified by study center. Body mass index (BMI) was added as an interaction term to examine effect modification by body size. Results The cohort included 769 participants with AKI and 769 matched controls. After median follow-up of 4.3 years, among AKI survivors, the rate of the combined CKD outcome was 84.7 per1000-person-years with BMI ≥30 kg/m2, 56.4 per 1000-person-years with BMI 25–29.9 kg/m2, and 72.6 per 1000-person-years with BMI 20–24.9 kg/m2. AKI was associated with a higher risk of combined CKD outcomes; adjusted-HR 2.43 (95%CI 1.87–3.16), with no evidence that this was modified by BMI (p for interaction = 0.3). After adjustment for competing risk of death, AKI remained associated with a higher risk of the combined CKD outcome (subdistribution-HR 2.27, 95%CI 1.76–2.92) and similarly, there was no detectable effect of BMI modifying this risk. Conclusions In this post-hospitalization cohort, we found no evidence for obesity modifying the association between AKI and development or progression of CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study

et al. 2021

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“…In addition to examining grip strength as a potential predictor of cardiovascular and cancer mortality, investigators have also shown the value of grip strength as a predictor of mortality in other pathologies. These pathologies include, but are not limited to, rheumatoid arthritis in women (relative risk 3.0), 96 type 2 diabetes in men (hazard ratio 0.90), 97 pneumonia (odds ratio 0.97), 98 renal disease (1.76 and 1.81), 99 and chronic obstructive pulmonary disease (hazard ratio 1.80). 100 For patients with chronic obstructive pulmonary disease Mohamed-Hussein et al noted a significant difference in mean grip strength between patients admitted to the intensive care who died (5.7kg) compared to those who survived (14.5kg).…”

Section: Grip Strength As a Biomarker Of Future Outcomesmentioning

confidence: 99%

<p>Grip Strength: An Indispensable Biomarker For Older Adults</p>

Bohannon

2019

CIA

577

382

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Grip strength has been proposed as a biomarker. Supporting this proposition, evidence is provided herein that shows grip strength is largely consistent as an explanator of concurrent overall strength, upper limb function, bone mineral density, fractures, falls, malnutrition, cognitive impairment, depression, sleep problems, diabetes, multimorbidity, and quality of life. Evidence is also provided for a predictive link between grip strength and all-cause and disease-specific mortality, future function, bone mineral density, fractures, cognition and depression, and problems associated with hospitalization. Consequently, the routine use of grip strength can be recommended as a stand-alone measurement or as a component of a small battery of measurements for identifying older adults at risk of poor health status.

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“…The GVHD is itself a risk factor for mortality [22], and systemic steroid therapy for GVHD treatment can cause infection [23]. Muscle strength itself is a risk factor for mortality in various clinical populations [24][25][26][27]. In the present study, the incidence of sepsis, thrombotic microangiopathy and/or veno-occulusive disease, and respiratory failure increased as muscle strength decreased, and the incidence of NRM within 1 year was signi cantly higher in the low LEMS group than in the middle and high LEMS groups.…”

Section: Discussionmentioning

confidence: 99%

Impact of lower extremity muscle strength on the clinical outcome of patients with allogeneic hematopoietic stem cell transplantation

Kondo¹,

Kagawa²,

Saito³

et al. 2021

Preprint

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Purpose Muscle strength decline is reported to predict mortality in many cancers. However, there is little knowledge of the relation between muscle strength decline and clinical outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed to determine the impact of pre-transplant lower extremity muscle strength (LEMS) on post-transplant overall survival (OS) and non-relapse mortality (NRM). Methods In this retrospective cohort study, 86 adult patients underwent allo-HSCT during 2012-2020. LEMS was defined as knee extension force divided by patient’s body weight. The patients were divided into low, middle, and high LEMS groups based on pre-transplant LEMS. OS was measured using the Kaplan–Meier method and the Cox proportional hazards model. Cumulative incidence of NRM was evaluated using the Fine and Gray method, with relapse considered as a competing risk event.Results Probability of OS was significantly lower in the low and middle LEMS groups (hazard ratio [HR] 2.98, p=0.020 and HR 2.68, p=0.034, respectively) than in the high LEMS group on multivariate analysis. OS at 5 years was 26.0%, 36.5%, and 72.5% in the low, middle, and high LEMS group, respectively. Risk of NRM was significantly lower in the low LEMS group (HR 5.62, p=0.038) than in the high LEMS group. Conclusions Pre-transplant LEMS was a significant factor in predicting OS and NRM.

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Handgrip strength and weight predict long-term mortality in acute kidney injury patients

Cited by 12 publications

References 27 publications

Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study

Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study

<p>Grip Strength: An Indispensable Biomarker For Older Adults</p>

Impact of lower extremity muscle strength on the clinical outcome of patients with allogeneic hematopoietic stem cell transplantation

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