Handgrip strength in end stage of renal disease—a narrative review

Oliveira, Mariana Cassani de; Bufarah, Marina Nogueira Berbel; Balbi, André Luís

doi:10.1186/s41110-018-0073-2

Cited by 14 publications

(9 citation statements)

References 27 publications

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“…8,9,12,18 HGS has shown to be a marker of nutritional status and clinical outcomes in end-stage renal disease (ESRD) patients, as recently outlined in a narrative review article. 28 There is currently a debate on how to best measure sarcopenia using different methods, techniques, and cut-points, especially in patients with ESRD. Therefore, the aim of this study is to investigate the prevalence of muscle wasting and weakness in an HD population using 3 different estimates of muscle mass by BIA (TSMI-Janssen and ASMI-Sergi [ASMI: Appendicular Skeletal Muscle Index]), MUAMC, and different cut-points for HGS (EWGSOP and FNIH).…”

Section: Introductionmentioning

confidence: 99%

Estimating the Prevalence of Muscle Wasting, Weakness, and Sarcopenia in Hemodialysis Patients

Slee

McKeaveney²,

Adamson³

et al. 2020

Journal of Renal Nutrition

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Haemodialysis (HD) patients suffer from nutritional problems, which include muscle wasting, weakness, and cachexia, and are associated with poor clinical outcomes. The European Working Group for Sarcopenia in Older People (EWGSOP) and Foundations for the National Institute of Health (FNIH) have developed criteria for the assessment of sarcopenia, including the use of non-invasive techniques such as Bioelectrical Impedance Analysis (BIA), anthropometry, and Hand Grip Strength (HGS) dynamometry. This study investigated the prevalence of muscle wasting, weakness, and sarcopenia using the EWGSOP and FNIH criteria. BIA was performed in 24 females (f) and 63 males (m) in the post-dialysis period. Total skeletal muscle mass (TSMM) and appendicular skeletal muscle mass (ASMM) were estimated and index values (i.e., muscle mass divided by height 2 [kg/m 2 ]) were calculated (Total Skeletal Muscle Index (TSMI) and Appendicular Skeletal Muscle Index (ASMI)). Mid-arm circumference and triceps skin-fold thickness were measured and mid-upper arm muscle circumference (MUAMC) calculated. HGS was measured using a standard protocol and Jamar dynamometer. Suggested cut-points for low muscle mass and HGS were utilized from EWGSOP and FNIH criteria, with prevalence estimated, including sarcopenia. The prevalence varied depending on methodology: low TSMI (moderate and severe sarcopenia combined) was 55% for whole group: 21% (f) and 68% (m). Low ASMI was 32% for whole group: 25% (f) and 35% (m). Low MUAMC was 25% for whole group: 0% (f) and 30% (m). ASMI highly correlated with body mass index (BMI) (r = 0.78, P < .001) and MUAMC (r = 0.68, P < .001). Muscle weakness was high regardless of cut-points used (50-71% (f); 60-79% (m)). Internationally, this is the first study comparing measures of muscle mass (TSMM and ASMM by BIA and MUAMC) and muscle strength (HGS) using this specific methodology in a haemodialysis population. Future work is required to confirm findings.

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Section: Introductionmentioning

confidence: 99%

Estimating the Prevalence of Muscle Wasting, Weakness, and Sarcopenia in Hemodialysis Patients

Slee

McKeaveney²,

Adamson³

et al. 2020

Journal of Renal Nutrition

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“…Whereas various definitions of PEW are available in scientific literature, they all disclose the extraction from energy stored in proteins, such as in the muscles, as compensation for an insufficient energy intake [43]. Consecutively, this whole body protein imbalance results in a reduced turnover of contractile proteins, muscle mass and force generating capacity, leading to physical impairments such as muscle weakness [44,45]. In this study, the MNA long form is used which is a reliable tool in the screening, differentiation and diagnosis of PEW in patients with ESKD [46,47]; moreover, in line with recent recommendations, objective measures of nutritional status are quantified as well [48].…”

Section: Plos Onementioning

confidence: 99%

Markers of protein-energy wasting and physical performance in haemodialysis patients: A cross-sectional study

et al. 2020

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Background Physical impairments are common in uraemia, as reflected by the high risk of falls of haemodialysis (HD) patients. Furthermore, these patients often suffer from malnutrition. Objective Up to now, it is unknown which aspects of physical performance are predominantly driven by malnutrition in HD patients. As this answer could steer different interventions, the aim of this study was to evaluate the cross-sectional relationship between nutritional status, muscle strength, exercise capacity and the risk of falls. Methods This study recruited HD patients between December 2016 and March 2018 from two hospital-based and five satellite dialysis units (registration number on clinicaltrial.gov: NCT03910426). The mini-nutritional assessment scale as well as objective measures of protein-energy wasting were obtained (total iron-binding capacity, total protein levels, and CRP). Physical assessment included muscle strength (quadriceps, handgrip force, and sitto-stand test), exercise capacity (six-minute walking test) and the risk of falls (Tinetti, FIC-SIT, and dialysis fall index). Their interrelationship was analysed by ridge regression models. Results Out of 113 HD patients (mean age 67 years ± 16.1, 57.5% male) 36.3% were malnourished according to the mini-nutritional assessment scale and a majority had impaired quadriceps force (86.7%), six-minute walking test (92%), and an increased risk of falls (73.5%). Total protein and CRP levels were identified as relevant nutritional factors in the association with physical performance. Nutritional parameters explained 9.2% of the variance in the risk of

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“…[ 4 ] These results can be explained by several characteristics (e.g., anemia, decrease in serum albumin and hemoglobin levels, presence of proteinuria, protein hypercatabolism, advanced age, and inflammation) that usually appear in CKD patients. [ 21 ] Ultimately, these characteristics lead to the reduction in muscle mass and strength. [ 21 ] In this study, the subjects with LMS were older than those with NMS, and the prevalence rate of proteinuria was higher in the subjects with LMS than in their counterparts.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[21] Ultimately, these characteristics lead to the reduction in muscle mass and strength. [21] In this study, the subjects with LMS were older than those with NMS, and the prevalence rate of proteinuria was higher in the subjects with LMS than in their counterparts. The subjects with BMI < 25 kg/m 2 and eGFR < 60 mL/ min/1.73 m 2 had a higher risk for LMS than those with BMI ≥ 25 kg/m 2 and eGFR < 60 mL/min/1.73 m 2 after controlling for CKD = chronic kidney disease, BMI = body mass index, BUN = blood urea nitrogen, eGFR = estimated glomerular filtration rate, HGS = hand grip strength, LMS = low muscle strength, MET = metabolic equivalents, SD = standard deviation.…”

Section: Discussionmentioning

confidence: 99%

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Association of renal function with muscle strength in Korean adults: A population-based study using the Korea National Health and Nutrition Examination Surveys (KNHANES) from 2014 to 2018

Yang

Choi

2022

Medicine

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Hand grip strength (HGS), a simple measure of upper limb muscle function, can be used to assess overall muscular strength, and reduced HGS in patients with poor renal functions has been observed. This study examined the associations between renal function and HGS, a surrogate marker of muscular strength, among a stratified sample of Korean adults. This study obtained data from the Korea National Health and Nutrition Examination Survey from 2014 to 2018, a cross-sectional and nationally representative survey conducted by the Korea Centers for Diseases Control and Prevention. In men, low muscle strength (LMS) and normal muscle strength (NMS) were defined as HGS < 28.9 kg and HGS ≥ 28.9 kg, respectively. In women, LMS and NMS were considered as HGS < 16.8 kg and HGS ≥ 16.8 kg, respectively. Of the 25,746 subjects in this study, there were 3603 (14.0%) and 22,143 (86.0%) subjects who displayed LMS and NMS, respectively. Subjects with estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 had a higher risk of developing LMS than those with eGFR ≥ 60 mL/min/1.73 m 2 after adjusting for age (odds ratio, 1.772; 95% CI, 1.498–2.096); the significant differences remained after adjusting for other factors including age. Similar tendencies were shown in men and women when analyzed according to gender; however, the risk of developing LMS was higher in men than in women. Results showed that decreased renal function was likely to contribute to an increased prevalence of LMS based on HGS. This association may assist in developing better strategies to estimate renal function in clinical or public health practice.

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Handgrip strength in end stage of renal disease—a narrative review

Cited by 14 publications

References 27 publications

Estimating the Prevalence of Muscle Wasting, Weakness, and Sarcopenia in Hemodialysis Patients

Estimating the Prevalence of Muscle Wasting, Weakness, and Sarcopenia in Hemodialysis Patients

Markers of protein-energy wasting and physical performance in haemodialysis patients: A cross-sectional study

Association of renal function with muscle strength in Korean adults: A population-based study using the Korea National Health and Nutrition Examination Surveys (KNHANES) from 2014 to 2018

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