Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity

Abstract

Background: Impaired exercise capacity is one of the most important prognostic factors for patients with chronic obstructive pulmonary disease (COPD). The 6-min walk test (6MWT) is a widely used method for assessing exercise capacity in patients with COPD. However, the 6MWT requires considerable effort from patients. Therefore, a less physically demanding, but also noninvasive, method is warranted. The objective of this study was to determine the predictors of the 6MWT distance (6MWD) in patients with COPD. Methods: This retrospective observational study enrolled 133 Japanese patients with COPD. All patients underwent the 6MWT, COPD assessment test (CAT), spirometry, respiratory muscle strength evaluation, body composition assessment, and handgrip strength (HGS) measurement. We examined the associations between the 6MWD and evaluated parameters. Results: From single regression analysis, the 6MWD was significantly correlated with age, CAT score, several spirometric measurements (e.g., percentages of forced vital capacity, forced expiratory volume in 1 s, and carbon monoxide diffusing capacity of the lungs [%DLCO]), respiratory muscle strength parameters (e.g., percentages of maximal expiratory and inspiratory pressures),

The relationship between sarcopenia and nesfatin-1 and ghrelin levels in patients with chronic obstructive pulmonary disease

“…Another important finding of this study was the correlation of handgrip strength with 6MWT, Nesfatin-1 and Ghrelin levels, and inverse correlation with CAT score positivity and mMRC score. Similar with our results Kyomoto et al (20) reported that carbon monoxide diffusing capacity of the lungs and handgrip strength were strongly correlated with 6MWT in their study on 133 patients with COPD. In previous literature, decreased ghrelin levels were associated with the nutritional status of the COPD patients and ghrelin has been suggested for the treatment of COPD patients (21)(22)(23).…”

The relationship between peak inspiratory flow and hand grip strength measurement in men with mild chronic obstructive pulmonary disease

“…Thus, it is not surprising that the evaluation of muscle strength required for COPD management can be performed with HGS. In fact, there was one recent report showing significant correlation between 6MWT and HGS in COPD [ 8 ]. Although HGS has not yet been used in general medical care for COPD, because of its simplicity—it can be measured simply by grasping the grip-strength meter—it may become a useful evaluation method in the future.…”

“…In COPD patients, HGS is associated with the antioxidant indicators serum club-cell protein 16 (CC16) and total sialic acid, which also predict forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) [ 7 ]. HGS is also associated with the distance walked in the 6MWT, frequency of COPD exacerbation, and inspiratory flow rate [ 8 – 10 ], but evidences in this area are insufficient.…”

Lactate level and handgrip test in migraine and fibromyalgia after self-myofascial release treatment

“…In fact, as recent and numerous studies showed, the handgrip test turns out to be a predictor of various diseases (Mgbemena, 2019;Kyomoto, 2019).…”