Hans Herloff Inhoffen in His Times (1906−1992)

Quinkert, Gerhard

doi:10.1002/ejoc.200300813

Cited by 8 publications

(2 citation statements)

References 95 publications

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“…7 The first orally active progestin "ethisterone" (pregneninolone, 17α-ethinyltestosterone) was synthesized by Inhoffen and colleagues in 1938. 11 Subsequently, the first oral contraceptive pill officially marketed in 1960 in the USA as Enovid and in the U.K. as Enavid contained the progestin norethynodrel (19norethynodrel) together with the estrogen mestranol as active ingredients. 12 Since then a number of synthetic progestins have been introduced at the global market.…”

Section: ■ Introductionmentioning

confidence: 99%

The Challenge Presented by Progestins in Ecotoxicological Research: A Critical Review

Kumar

Johnson

Trubiroha

et al. 2015

Environ. Sci. Technol.

141

104

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Around 20 progestins (also called gestagens, progestogens, or progestagens) are used today in assisting a range of medical conditions from endometrial cancer to uterine bleeding and as an important component of oral contraception. These progestins can bind to a wide range of receptors including progestin, estrogen, androgen, glucocorticoid, and mineralocorticoid receptor, as well as sex hormone and corticosteroid binding globulins. It appears that only five of these (four synthetic and one natural) progestins have so far been studied in sewage effluent and surface waters. Analysis has reported values as either nondetects or low nanograms per liter in rivers. Seven of the progestins have been examined for their effects on aquatic vertebrates (fish and frogs). The greatest concern is associated with levonorgestrel, norethisterone, and gestodene and their ability to reduce egg production in fish at levels of 0.8-1.0 ng/L. The lack of environmental measurements, and some of the contradictions in existing values, however, hampers our ability to make a risk assessment. Only a few nanograms per liter of ethynodiol diacetate and desogestrel in water would be needed for fish to receive a human therapeutic dose for these progestins according to modeled bioconcentration factors. But for the other synthetic progestins levels would need to reach tens or hundreds of nanograms per liter to achieve a therapeutic dose. Nevertheless, the wide range of compounds, diverse receptor targets, and the effect on fish reproduction at sub-nanogram-per-liter levels should prompt further research. The ability to impair female reproduction at very low concentrations makes the progestins arguably the most important pharmaceutical group of concern after ethinylestradiol.

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Section: ■ Introductionmentioning

confidence: 99%

The Challenge Presented by Progestins in Ecotoxicological Research: A Critical Review

Kumar

Johnson

Trubiroha

et al. 2015

Environ. Sci. Technol.

141

104

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“…Chlorophyll (Chl) first came to me in a bottle containing approximately 1 kg of “Phäophytin Sandoz”, handed over by Hans-Herloff Inhoffen [ 1 ], the big boss of organic chemistry at the Technical University of Braunschweig. Herbert Wolf, one of the sous-chefs, had proposed using the Chl-macrocycle as a platform for studying the stereochemistry of side-chains for a diploma and later doctoral degree.…”

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confidence: 99%

Chlorophylls: A Personal Snapshot

Scheer¹

2022

Molecules

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Chlorophylls provide the basis for photosynthesis and thereby most life on Earth. Besides their involvement in primary charge separation in the reaction center, they serve as light-harvesting and light-sensing pigments, they also have additional functions, e.g., in inter-system electron transfer. Chlorophylls also have a wealth of applications in basic science, medicine, as colorants and, possibly, in optoelectronics. Considering that there has been more than 200 years of chlorophyll research, one would think that all has been said on these pigments. However, the opposite is true: ongoing research evidenced in this Special Issue brings together current work on chlorophylls and on their carotenoid counterparts. These introductory notes give a very brief and in part personal account of the history of chlorophyll research and applications, before concluding with a snapshot of this year’s publications.

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