Hantavirus

Hammerbeck, Christopher; Wahl‐Jensen, Victoria; Hooper, Jay W.

doi:10.1016/b978-0-12-369408-9.00023-8

Cited by 6 publications

(3 citation statements)

References 211 publications

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“…The most lethal HFRS-associated Hantavirus is the Hantaan virus in Asia whereas in Europe it is the Puumala virus and Dobrava virus. Andes virus (ANDV) and Sin Nombre virus (SNV) are the most lethal of the type ( Hammerbeck et al, 2009 ).…”

Section: Types Of Virusesmentioning

confidence: 99%

An overview of viruses discovered over the last decades and drug development for the current pandemic

Mirza

Shamshad

Osra

et al. 2021

European Journal of Pharmacology

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Section: Types Of Virusesmentioning

confidence: 99%

An overview of viruses discovered over the last decades and drug development for the current pandemic

Mirza

Shamshad

Osra

et al. 2021

European Journal of Pharmacology

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“…Interestingly, their immunogenicity apparently differs in different animal models. The M segment of ANDV was presented as immunogenic in nonhuman primates and rabbits but not in hamsters (Hammerbeck et al, 2009). Three groups of nine volunteers were vaccinated with DNA vaccines for HTNV, PUUV or with a mixture of both vaccines expressing G1 and G2 genes of these viruses within the phase I study.…”

Section: Dna Vaccinesmentioning

confidence: 99%

Antiviral therapy and prevention against hantavirus infections

Szabó¹

2017

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Hantaviruses are emerging zoonoses hosted by small mammals. In humans, they cause two diseases. Hemorrhagic fever with renal syndrome is mainly caused by Dobrava-Belgrade virus, Puumala virus, Seoul virus and Hantaan virus in Asia and Europe. On the other hand, the most important causes of hantavirus cardiopulmonary syndrome are Sin Nombre virus and Andes virus in Americas. Ribavirin yet remains the only licensed drug against the hantavirus infections, but its sufficient antiviral activity remains an issue under discussion. There are still no available vaccines against hantaviruses except of some inactivated virus vaccines licensed only in East-Asian countries. Some of the vaccines are under development in pre-clinical stages. The review discuses about specific compounds with approved antiviral activity against hantaviruses. Other approaches such as development of vaccines, are compiled as well.

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“…Hantaviruses (family Bunyaviridae ) comprise an emerging global health threat, with approximately 50 000 human cases of hantavirus infections occurring worldwide per year . The main route of transmission is through inhalation of aerosols produced by excreta from infected rodent reservoirs .…”

mentioning

confidence: 99%

Circulation and diagnostics of Puumala virus in Norway: nephropatia epidemica incidence and rodent population dynamics

Milhano

Korslund

Evander

et al. 2017

APMIS

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Hantaviruses pose a public health concern worldwide causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Puumala virus (PUUV) is the most prevalent hantavirus in Central and Northern Europe, and causes a mild form of HFRS, also known as nephropathia epidemica (NE). In nature, the main host of PUUV is the bank vole (Myodes glareolus), and transmission to humans occurs through inhalation of aerosols from rodent excreta. Nephropathia epidemica is particularly prevalent in Nordic countries, however, few studies of PUUV have been performed in Norway. The aim of this study was to analyse the dynamics of PUUV in Norway and compare with bank vole population dynamics, and also to complement the current diagnostic methodology of NE in Norway. Our results showed a significant seasonal and geographical variation of NE, and a general parallel peak trend between bank vole population densities and human NE incidence. A real-time and a nested PCR were successfully established as an invaluable diagnostic tool, with detection and sequencing of PUUV in a human serum sample for the first time in Norway. Phylogenetic analysis showed clustering of the obtained human sample with previous Norwegian bank vole isolates.

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Hantavirus

Cited by 6 publications

References 211 publications

An overview of viruses discovered over the last decades and drug development for the current pandemic

An overview of viruses discovered over the last decades and drug development for the current pandemic

Antiviral therapy and prevention against hantavirus infections

Circulation and diagnostics of Puumala virus in Norway: nephropatia epidemica incidence and rodent population dynamics

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