Hantavirus Pulmonary Syndrome IN THE RURAL AREA OF JUQUITIBA, SÃO PAULO METROPOLITAN AREA, BRAZIL

Vasconcelos, Maristela Inês Osawa; Lima, Vanessa Pereira de; Iversson, Lygia Busch; Rosa, Michele De; Rosa, Annachiara; Rosa, Edvaldo Santa; Pereira, Luiz Eloy; Nassar, E.; Katz, Gizelda; Matida, Luiza Harunari; Zaparoli, M. A.; Ferreira, J. J.; Peters, C. J.

doi:10.1590/s0036-46651997000400012

Cited by 32 publications

(1 citation statement)

References 2 publications

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“…Subsequently, several other hantaviruses that cause HCPS have been identified in different reservoirs in the Americas. These include but are not limited to Andes virus ( Orthohantavirus andesense , ANDV) from Oligoryzomys longicaudatus ; Black Creek Canal virus ( Orthohantavirus nigrorivense , BCCV) from Sigmodon hispidus ; New York virus (NYV) from Peromyscus leucopus ; Choclo virus ( Orthohantavirus chocloense , CHOV) and Maporal Virus ( Orthohantavirus maporalense , MAPV) from Oligoryzomys fulvescens ; Rio Mamore virus (RIOMV) from Oligoryzomys microtis ; Bayou virus (BAYV) from Oryzomys palustris ; Laguna Negra virus ( Orthohantavirus negraense , LANV) from Calomys laucha ; and Juquitiba virus (JUQV) from Oligoryzomys nigripes [ 5 , 11 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In South America, clinical cases of HCPS have been reported in Argentina [ 24 ], Uruguay [ 25 ], Brazil [ 26 ], Chile [ 27 , 28 ], Bolivia [ 29 ], Peru [ 30 , 31 ], and Paraguay [ 32 ].…”

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confidence: 99%

Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay

Nnamani,

Spruill-Harrell,

Williams

et al. 2023

Viruses

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Several hantaviruses result in zoonotic infections of significant public health concern, causing hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS) in the Old and New World, respectively. Given a 35% case fatality rate, disease-causing New World hantaviruses require a greater understanding of their biology, genetic diversity, and geographical distribution. Juquitiba hantaviruses have been identified in Oligoryzomys nigripes in Brazil, Paraguay, and Uruguay. Brazil has reported the most HCPS cases associated with this virus. We used a multiplexed, amplicon-based PCR strategy to screen and deep-sequence the virus harbored within lung tissues collected from Oligoryzomys species during rodent field collections in southern (Itapúa) and western (Boquerón) Paraguay. No Juquitiba-like hantaviruses were identified in Boquerón. Herein, we report the full-length S and M segments of the Juquitiba hantaviruses identified in Paraguay from O. nigripes. We also report the phylogenetic relationships of the Juquitiba hantaviruses in rodents collected from Itapúa with those previously collected in Canindeyú. We showed, using the TN93 nucleotide substitution model, the coalescent (constant-size) population tree model, and Bayesian inference implemented in the Bayesian evolutionary analysis by sampling trees (BEAST) framework, that the Juquitiba virus lineage in Itapúa is distinct from that in Canindeyú. Our spatiotemporal analysis showed significantly different time to the most recent ancestor (TMRA) estimates between the M and S segments, but a common geographic origin. Our estimates suggest the additional geographic diversity of the Juquitiba virus within the Interior Atlantic Forest and highlight the need for more extensive sampling across this biome.

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Section: Introductionmentioning

confidence: 99%

Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay

Nnamani,

Spruill-Harrell,

Williams

et al. 2023

Viruses

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Genetic investigation of novel hantaviruses causing fatal HPS in Brazil

Johnson¹,

et al. 1999

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Although hantavirus pulmonary syndrome (HPS) was discovered in North America in 1993, more recent investigations have shown that the disease is a much larger problem in South America, where a greater number of cases and HPS-associated viruses have now been detected. Here we describe the genetic investigation of three fatal HPS cases from Brazil, including a 1995 case in Castelo dos Sonhos (CAS) in the state of Mato Grosso and two 1996 cases in the counties of Araraquara (ARA) and Franca (FRA), in the state of São Paulo. Reverse transcription-polymerase chain reaction (RT-PCR) products representing fragments of the hantavirus N, G1, and G2 coding regions were amplified from patient acute-phase serum samples, and the nucleotide (nt) sequences (394, 259, and 139 nt, respectively) revealed high deduced amino acid sequence identity between ARA and FRA viruses (99.2%, 96.5%, and 100%, respectively). However, amino acid differences of up to 14.0% were observed when ARA and FRA virus sequences were compared with those of the geographically more distant CAS virus. Analysis of a 643-nt N coding region and a 1734-nt predominantly G2-encoding region of ARA and CAS virus genomes confirmed that these Brazilian viruses were distinct and monophyletic with previously characterized Argentinean hantaviruses, and suggested that Laguna Negra (LN) virus from Paraguay was ancestral to both the Brazilian and Argentinean viruses. The phylogenetic tree based on the N coding fragment also placed LN in a separate clade with Rio Mamore virus from Bolivia. At the amino acid level, ARA and CAS viruses appeared more closely related to the Argentinean viruses than they were to each other. Similarly, analysis of the diagnostic 139-nt G2 fragment showed that the Juquitiba virus detected in a 1993 fatal HPS case close to São Paulo city, Brazil was closer to Argentinean viruses than to ARA or CAS viruses. These data indicate that at least three different hantavirus genetic lineages are associated with Brazilian HPS cases.

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Transmission of Black Creek Canal virus between cotton rats

et al. 2000

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Black Creek Canal (BCC) virus is a hantavirus associated with hantavirus pulmonary syndrome in southeastern North America. The virus was isolated from the spleen of a cotton rat (Sigmodon hispidus) trapped in southern Florida. Our previous studies have shown that we could consistently infect male cotton rats with BCC virus in the laboratory. These animals became persistently infected and virus could be detected in salivary glands, urine, and feces. In this report we show: (1) female and male cotton rats are equally susceptible to BCC virus infection, (2) susceptibility to infection was not influenced by age, (3) all inoculated rats transmitted the infection to uninoculated cage mates, and (4) offspring of infected rats became infected despite the presence of high maternal antibodies. The course of BCC virus infection, as determined by antibody response and the ability to isolate or detect virus, appeared to be similar regardless of whether the rats obtained their infection by inoculation or contact with inoculated rats. J. Med. Virol. 60:70-76, 2000. Published 2000 Wiley-Liss, Inc.

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Hantavirus Pulmonary Syndrome IN THE RURAL AREA OF JUQUITIBA, SÃO PAULO METROPOLITAN AREA, BRAZIL

Cited by 32 publications

References 2 publications

Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay

Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay

Genetic investigation of novel hantaviruses causing fatal HPS in Brazil

Transmission of Black Creek Canal virus between cotton rats

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