2022
DOI: 10.3389/fcell.2021.807313
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HAP2-Mediated Gamete Fusion: Lessons From the World of Unicellular Eukaryotes

Abstract: Most, if not all the cellular requirements for fertilization and sexual reproduction arose early in evolution and are retained in extant lineages of single-celled organisms including a number of important model organism species. In recent years, work in two such species, the green alga, Chlamydomonas reinhardtii, and the free-living ciliate, Tetrahymena thermophila, have lent important new insights into the role of HAP2/GCS1 as a catalyst for gamete fusion in organisms ranging from protists to flowering plants… Show more

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Cited by 12 publications
(13 citation statements)
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References 235 publications
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“…Sexual development in T. thermophila is initiated by nutrient deprivation 20 . Following starvation, physical interactions between cells of different mating types lead to rapid upregulation of genes involved in cell-cell recognition and adherence, membrane fusion, meiosis, and exchange of migratory pronuclei between mating cells resulting in karyogamy [20][21][22]31 .…”
Section: Identification Of Genes Required For Stable Pairing Of Matin...mentioning
confidence: 99%
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“…Sexual development in T. thermophila is initiated by nutrient deprivation 20 . Following starvation, physical interactions between cells of different mating types lead to rapid upregulation of genes involved in cell-cell recognition and adherence, membrane fusion, meiosis, and exchange of migratory pronuclei between mating cells resulting in karyogamy [20][21][22]31 .…”
Section: Identification Of Genes Required For Stable Pairing Of Matin...mentioning
confidence: 99%
“…Sexual development in T. thermophila is initiated by nutrient deprivation 20 . Following starvation, physical interactions between cells of different mating types lead to rapid upregulation of genes involved in cell-cell recognition and adherence, membrane fusion, meiosis, and exchange of migratory pronuclei between mating cells resulting in karyogamy [20][21][22]31 . Initially, interactions between cells are transient, but within 1.5 hr post-mixing (30 o C) complementary mating types begin to form mechanically stable pairs that remain adherent until they naturally separate as sexual progeny roughly 12 hr after their initial interaction (Fig.…”
Section: Identification Of Genes Required For Stable Pairing Of Matin...mentioning
confidence: 99%
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“…Additionally, some species can form reproductive cysts, much like Ichthyophthirius and Cryptocaryon 109 . Finally, Tetrahymena species containing micronuclei have the potential to undergo sexual reproduction (via conjugation), an activity that has been extensively studied in the laboratory model, Tetrahymena thermophila 136,137 …”
Section: Cultivation Of Fish Ciliatesmentioning
confidence: 99%
“…109 Finally, Tetrahymena species containing micronuclei have the potential to undergo sexual reproduction (via conjugation), an activity that has been extensively studied in the laboratory model, Tetrahymena thermophila. 136,137 In parallel with clinical studies on fish, developments in molecular phylogeny have resulted in major advances in our understanding of ciliate taxonomy. 111,138,139 These advances allow discrimination of parasite isolates based on molecular markers and have led to the identification of formerly cryptic species and a wholesale revamping of the Tetrahymena phylogenetic tree.…”
Section: General Biologymentioning
confidence: 99%