Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders

Hollá, Lýdie Izakovičová; ková, Barbara Hrdlič; Schüller, Marcel; Bučková, Dana; Kindlová, Dagmar; Izakovič, Vincent; Vašků, Anna

doi:10.1016/j.humimm.2010.03.004

Cited by 14 publications

(18 citation statements)

References 47 publications

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“…It may be suggested that this group of HD patients had a similar gene regulation of IL-18 expression as control persons, probably showing responsiveness to various HBV vaccines of about 85-90% [30,42] . In hemodialyzed nonresponders, the frequency of -1297CC (rs360719) in both the recessive model (CC vs. CT + TT) and the additive model (CC vs. TT) was lower than that in our own control population, in healthy subjects living in the South Moravia re-gion of the Czech Republic [41] and in Spain, Italy and Argentina [24] .…”

Section: Discussioncontrasting

confidence: 62%

“…To have at least an approximate reference of IL-18 genotypes obtained in HD patients to those shown in healthy subjects, we have compared our results of HD patients with IL-18 genotypes with those of blood donors from the Wielkopolska region of Poland and with available data of other authors [24,41] . In both the CC versus CT + TT model and the CC versus TT model, the frequency of -1297CC (rs360719) in HD responders was not significantly different than that in the control Caucasian population described by others [24,41] and in our study. It may be suggested that this group of HD patients had a similar gene regulation of IL-18 expression as control persons, probably showing responsiveness to various HBV vaccines of about 85-90% [30,42] .…”

Section: Discussionmentioning

confidence: 99%

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<i>Interleukin-18</i> Promoter Polymorphism and Development of Antibodies to Surface Antigen of Hepatitis B Virus in Hemodialysis Patients

Grzegorzewska¹,

Wobszal²,

Jagodzińśki³

2011

Kidney Blood Press Res

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Background: Interleukin (IL)-18 is involved in hepatitis B virus (HBV) clearance and augments antibodies against surface antigen of HBV (anti-HBsAg) production during DNA vaccination. The IL-18 –1297C>T (rs360719) polymorphism may modulate the IL-18 expression. Aim: To determine the potential association of IL-18 –1297C>T polymorphism with development of anti-HBsAg in hemodialysis (HD) patients. Methods: The frequency of IL-18 –1297C>T alleles and genotypes was identified by polymerase chain reaction restriction fragment length polymorphism in 435 HD patients. Group 1 (n = 219) developed an anti-HBsAg titer >10 IU/l as a result of vaccination or HBV transmission. Group 2 (n = 216) included patients who did not develop an anti-HBsAg titer >10 IU/l in response to at least one full series of vaccination or HBV transmission. The significance of genotype frequency was tested using the Fisher exact test. Results: In group 1, the frequencies of –1297CC, –1297CT and –1297TT genotypes were 7.3, 39.7 and 53.0%, respectively, and in group 2 they were 1.9, 42.1 and 56.0%, respectively. The odds ratio for CC versus CT + TT was 0.239 (95% CI 0.079–0.728, p = 0.010), and for CC versus TT it was 0.240 (95% CI 0.078–0.738, p = 0.009). Conclusion: In HD patients, the IL-18 –1297CC genotype may play a role in anti-HBsAg development in response to HBV surface antigen.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

<i>Interleukin-18</i> Promoter Polymorphism and Development of Antibodies to Surface Antigen of Hepatitis B Virus in Hemodialysis Patients

Grzegorzewska¹,

Wobszal²,

Jagodzińśki³

2011

Kidney Blood Press Res

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“…The studies identified and their main characteristics were summarized in Table 1. Of the 21 case-control studies included, an array of allergic diseases including AA [31–40], AD [41–45], AR [10, 46], drug allergy [47, 48], and other types [49, 50] was involved. Of all studies included, 12 studies were conducted in Asian populations [31, 33, 36, 37, 39, 40, 43–48], while 9 studies were performed in Caucasian populations [10, 32, 34, 35, 38, 41, 42, 49, 50].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 21 case-control studies included, an array of allergic diseases including AA [31–40], AD [41–45], AR [10, 46], drug allergy [47, 48], and other types [49, 50] was involved. Of all studies included, 12 studies were conducted in Asian populations [31, 33, 36, 37, 39, 40, 43–48], while 9 studies were performed in Caucasian populations [10, 32, 34, 35, 38, 41, 42, 49, 50]. There were 16 studies concerning IL-18 −607C/A [10, 31, 32, 35–40, 44–50] and 19 studies concerning −137G/C [10, 31–37, 39–45, 47–49].…”

Section: Resultsmentioning

confidence: 99%

“…Of all studies included, 12 studies were conducted in Asian populations [31, 33, 36, 37, 39, 40, 43–48], while 9 studies were performed in Caucasian populations [10, 32, 34, 35, 38, 41, 42, 49, 50]. There were 16 studies concerning IL-18 −607C/A [10, 31, 32, 35–40, 44–50] and 19 studies concerning −137G/C [10, 31–37, 39–45, 47–49]. The genotype distributions among the controls of all studies were in agreement with HWE, except 2 studies for −607C/A [38, 46] and 1 study for −137G/C [33].…”

Section: Resultsmentioning

confidence: 99%

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The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

Cheng

Hao

Zhou

et al. 2014

BioMed Research International

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Recent studies have suggested that IL-18 −607C/A and −137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive. Therefore, we performed a meta-analysis to clarify whether IL-18 −607C/A and −137G/C polymorphisms were associated with the risk of allergic disease. A total of 21 studies including 5,331 cases and 9,658 controls were involved in this meta-analysis. In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 −607C/A or −137G/C polymorphism and the risk of allergic disease (all P > 0.05). However, in a stratified analysis by type of allergic disease, our results indicated that IL-18 −607C/A polymorphism was associated with a significantly decreased risk of allergic asthma in heterozygous comparison and IL-18 −137G/C was associated with a significantly decreased risk of allergic dermatitis in recessive model and homozygous comparison. In the stratified analysis by source of control, IL-18−607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 −137G/C only significantly decreased risk was found in the hospital-based subgroup. Our meta-analysis suggests that IL-18 −607C/A and −137G/C polymorphisms may be protective factors for the risk of allergic asthma and allergic dermatitis, respectively.

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Interleukin-18 −607C/A Gene Polymorphism in Egyptian Asthmatic Children

et al. 2014

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No significant statistical difference was encountered regarding the distribution of IL-18 -607C/A genotypes and allele frequencies in asthma patients and healthy controls. Also, there were no significant associations between asthma severity and different genotypes or alleles. The median value of the total serum IgE level in asthmatic cases with the mutant genotype (AA) was significantly higher than in the control group. Thus, IL-18 -607AA genotype frequency might be related to higher total serum IgE.

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Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders

Cited by 14 publications

References 47 publications

<i>Interleukin-18</i> Promoter Polymorphism and Development of Antibodies to Surface Antigen of Hepatitis B Virus in Hemodialysis Patients

<i>Interleukin-18</i> Promoter Polymorphism and Development of Antibodies to Surface Antigen of Hepatitis B Virus in Hemodialysis Patients

The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

Interleukin-18 −607C/A Gene Polymorphism in Egyptian Asthmatic Children

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