2011
DOI: 10.1016/j.ejso.2010.11.001
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Haptocorrin as marker of disease progression in fibrolamellar hepatocellular carcinoma

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Cited by 34 publications
(21 citation statements)
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“…In addition, upregulation of TCN1 both in plasm and tumor tissue have been reported in a number of solid neoplasms including HCC, salivary gland tumors, cancers of the breast, kidney, lung and stomach, and endocervical adenocarcinoma 15, 17-24, 41. Previous studies have suggested that increased serum level and expression of TCN1 in patients with HCC or secondary liver metastasis might be due to a diminished clearance of TCN1 in the liver 38, 42. On the other hand, overexpression of TCN1 in other solid malignancies has been inferred mainly to be an excess synthesis of its production by tumor cells themselves or to an increase of hypergranulocytosis 17, 36, 38.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, upregulation of TCN1 both in plasm and tumor tissue have been reported in a number of solid neoplasms including HCC, salivary gland tumors, cancers of the breast, kidney, lung and stomach, and endocervical adenocarcinoma 15, 17-24, 41. Previous studies have suggested that increased serum level and expression of TCN1 in patients with HCC or secondary liver metastasis might be due to a diminished clearance of TCN1 in the liver 38, 42. On the other hand, overexpression of TCN1 in other solid malignancies has been inferred mainly to be an excess synthesis of its production by tumor cells themselves or to an increase of hypergranulocytosis 17, 36, 38.…”
Section: Discussionmentioning
confidence: 99%
“…The underlying pathogenesis leading to high Cbl levels is poorly elucidated, with a few exceptions (6,10,11). It is not thought to involve increased Cbl intake because intestinal absorption capacity is saturable (31) and high physiological consumption does not increase plasma Cbl levels substantially.…”
Section: Discussionmentioning
confidence: 99%
“…On one hand, a high prevalence of elevated Cbl levels has been reported in patients with liver cancer (6,7), other solid tumors (8,9), and hematological malignancies (10,11). On the other hand, some studies have indicated a high prevalence of cancer, both hematological and solid tumors, among patients with high Cbl levels (3,5).…”
mentioning
confidence: 99%
“…Other serum findings in patients with FLC include elevated transcobalamin I levels [7, 37, 38], transcobalamin 2 [7], and vitamin B12 binding capacity [7, 19, 23, 37, 39, 40]. Transcobalamin I is also known as haptocorrin and is a glycoprotein that in normal physiology is made largely in the salivary glands, from where it is secreted into the digestive tract and protects vitamin B12 (also known as cobalamin) from degradation in the stomach.…”
Section: Clinical Findingsmentioning
confidence: 99%