Haptocorrin in humans

Mørkbak, Anne Louise; Poulsen, Steen Seier; Nexø, Ebba

doi:10.1515/cclm.2007.343

Cited by 67 publications

(65 citation statements)

References 49 publications

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“…The largest change after 7 days was in sion compared to the RPMI-CPN group after 2 weeks in culture. This finding is consistent with the increase in the gene for the cobalamin-binding protein haptocorrin, a vitamin B 12 carrier (15). Factors with significant secreted VEGF measured after 2 weeks (240%).…”

Section: Resultssupporting

confidence: 80%

Functional Modulation of Choroid Plexus Epithelial Clusters in Vitro for Tissue Repair Applications

et al. 2011

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One of the primary obstacles in the restoration or repair of damaged tissues is the temporospatial orchestration of biological and physiological events. Cellular transplantation is an important component of tissue repair as grafted cells can serve as replacement cells or as a source of secreted factors. But few, if any, primary cells can perform more than a single tissue repair function. Epithelial cells, derived from the choroid plexus (CP), are an exception to this rule, as transplanted CP is protective and regenerative in animal models as diverse as CNS degeneration and dermal wound repair. They secrete a myriad of proteins with therapeutic potential as well as matrix and adhesion factors, and contain responsive cytoskeletal components potentially capable of precise manipulation of cellular and extracellular niches. Here we isolated CP from neonatal porcine lateral ventricles and cultured the cells under a variety of conditions to specifically modulate tissue morphology (2D vs. 3D) and protein expression. Using qRT-PCR analysis, transmission electron microscopy, and gene microarray studies we demonstrate a fine level of control over CP epithelial cell clusters opening further opportunities for exploration of the therapeutic potential of this unique tissue source.

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Section: Resultssupporting

confidence: 80%

Functional Modulation of Choroid Plexus Epithelial Clusters in Vitro for Tissue Repair Applications

et al. 2011

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“…These results agree well with our previous attempt to estimate the amounts of analogs attached to HC by calculating holoHC minus HC-Cbl, where HC-Cbl was defined as total Cbl minus holoTC. Using this method, we found that Cbl analogs account for about 40% of all corrinoids on HC in non-Cbldeficient donors, and about 60% of all corrinoid on HC among Cbl-deficient patients (24 ).…”

Section: Discussionmentioning

confidence: 99%

A New Principle for Measurement of Cobalamin and Corrinoids, Used for Studies of Cobalamin Analogs on Serum Haptocorrin

Hardlei

Nexø

2009

Clinical Chemistry

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“…TCsat is expected to correlate with MMSE similarly to holoTC, because holoTC-the amount of B 12 available for cellular uptake (11 )-is included in this value. In contrast, B 12 -HC is not directly available to all cells (18,20 ). The strong correlation of B 12 -HC with MMSE is therefore likely to be indirect.…”

Section: Holotc and B 12 -Hc Correlate To Cognitive Impairment And Tomentioning

confidence: 98%

Association of Cognitive Impairment with Combinations of Vitamin B12–Related Parameters

et al. 2011

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BACKGROUND: Low vitamin B 12 concentrations have been associated with higher risks of cognitive impairment, but whether these associations are causal is uncertain. The associations of cognitive impairment with combinations of vitamin B 12 , holotranscobalamin, methylmalonic acid, and total homocysteine, and with the vitamin B 12 transport proteins transcobalamin and haptocorrin, have not been previously studied.

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Haptocorrin in humans

Cited by 67 publications

References 49 publications

Functional Modulation of Choroid Plexus Epithelial Clusters in Vitro for Tissue Repair Applications

Functional Modulation of Choroid Plexus Epithelial Clusters in Vitro for Tissue Repair Applications

A New Principle for Measurement of Cobalamin and Corrinoids, Used for Studies of Cobalamin Analogs on Serum Haptocorrin

Association of Cognitive Impairment with Combinations of Vitamin B12–Related Parameters

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