Haptoglobin Types in Chinese Ethnic Groups

Zhao, Haijiao; Gui-yin, Zhang; Yuqin, Duan; Yu, Shihui

doi:10.1159/000154130

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…The statement that HP subtype distributions are related to geography and population are validated in our study. We found the HP 1 allele frequency is about 0.28, which was close to the results in East Asia and similar to the data of Beijing, China 4 , 21 . Furthermore, we reconfirmed the interesting link between HP alleles and serum concentration that the higher the amount of HP del allele and HP 2 allele, the lower the concentration 5 , 17 , 18 .…”

Section: Discussionsupporting

confidence: 90%

Genotype-specific reference interval of haptoglobin tests in a Chinese population on the BN II System

Lei

Guo

et al. 2023

Sci Rep

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The distribution of Haptoglobin (HP) subtypes differs according to race and geography. It was also confirmed that the serum HP concentration was substantially affected by the HP subtypes. This study aimed to investigate the HP subtypes in northern Chinese and to establish reference intervals for the major HP subtypes using the BN II system. 1195 individuals were included in the study, grouped by haptoglobin subtype, and tested for concentrations by BN II System. Analysis of reference range was performed according to the EP28-A3c guideline. The need to establish reference ranges for subtype, gender, and age groupings was confirmed by the Z-test. The 2.5th and 97.5th percentiles were used as the upper and lower limits of the reference interval, respectively. In the population we investigated, the HP2-2 subtype had the highest proportion, accounting for 49.3%, followed by HP2-1 (38.0%), HP1-1 (7.2%). In addition, about 5.5% of individuals had HPdel-related subtypes. The concentrations of the major subtypes (HP1-1, HP2-1, HP2-2) were significantly different, and it was necessary to establish reference ranges by grouping according to the results of the Z-test. The reference intervals were as follows: HP1-1, 0.37–2.19 g/L; HP2-1, 0.38–2.12 g/L; HP2-2, 0.12–1.51 g/L. Significant differences in HP concentrations between genders and ages were found, however, it was not necessary to establish separate reference interval since the results of the Z-test was negative. We have established reference ranges of serum haptoglobin concentrations based on subtypes, which are necessary for the clinical application of haptoglobin.

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Section: Discussionsupporting

confidence: 90%

Genotype-specific reference interval of haptoglobin tests in a Chinese population on the BN II System

Lei

Guo

et al. 2023

Sci Rep

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“…The Hp 1 allele frequency in a Korean population was calculated to be 0´32, which was lower than those of North America Caucasians (0´38±0´46) 6,17,18 and Europeans (0´36±0´46), 6,19±21 but higher than those of Japanese (0´26) 22 and Chinese (0´27). 23 The three major phenotypes of human haptoglobin, designated Hp 1-1, Hp 2-1 and Hp 2-2, are due to two alleles Hp 1 and Hp 2 . 2,3 The Hp 1 allele is subdivided into Hp 1F and Hp 1S as a consequence of a point mutation of the original Hp 1 allele.…”

Section: Discussionmentioning

confidence: 99%

Distribution of haptoglobin phenotypes in a Korean population, using the semi-automated PhastSystem

Yang

Min²,

Park³

et al. 2000

Ann Clin Biochem

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SUMMARY.We have established a new phenotyping method for haptoglobin, based on sodium dodecyl sulphate±polyacrylamide gel electrophoresis using the PhastSystem (Pharmacia Biotech, Uppsala, Sweden), followed by immunoblotting for detection. We measured haptoglobin concentrations and determined the haptoglobin phenotypes of 316 healthy Koreans using this method: 31 (9´8%) were of Hp 1-1 type, 140 (44´3%) of Hp 2-1 type and 145 (45´9%) of Hp 2-2 type. The haptoglobin allele frequencies were calculated to be 0´32 for Hp 1 and 0´68 for Hp 2 . We were able to visualize up to 12 bands from the human Hp 2-2 polymeric series, with molecular weights in the range 171´9 10 3 to 802´2 10 3 . The reference range of serum haptoglobin concentrations obtained by the IFCC (International Federation of Clinical Chemistry) standard method was 0´27±2´14 g/L. The serum haptoglobin concentration in Koreans was similar to that of Caucasians, but the Hp 1 allele frequency was lower in Koreans. Our method could be used in clinical laboratories as a simple and practical method of haptoglobin phenotyping. In addition, the Hp 2-2 polymeric series could be used as high molecular weight standards.Haptoglobin is a glycoprotein that is expressed by a genetic polymorphism as three major phenotypes: Hp 1-1, Hp 2-1 and Hp 2-2.

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Polymorphisms of haptoglobin modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia

Mayasari

Cheng

et al. 2022

Eur J Nutr

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Haptoglobin Types in Chinese Ethnic Groups

Abstract: The distribution of haptoglobin (HP) types was examined in six different Chinese ethnic groups. The gene frequencies were compared among these groups and to those reported in other Chinese Han populations. The effects of sex and age on the distribution of HP types are also discussed.

Cited by 9 publications

References 2 publications

Genotype-specific reference interval of haptoglobin tests in a Chinese population on the BN II System

Genotype-specific reference interval of haptoglobin tests in a Chinese population on the BN II System

Distribution of haptoglobin phenotypes in a Korean population, using the semi-automated PhastSystem

Polymorphisms of haptoglobin modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia

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