Hard Block Degradable Polycarbonate Urethanes: Promising Biomaterials for Electrospun Vascular Prostheses

Ehrmann, Katharina; Potzmann, Paul; Dworak, Claudia; Bergmeister, Helga; Eilenberg, Magdalena; Grasl, Christian; Koch, Thomas; Schima, Heinrich; Liska, Robert; Baudis, Stefan

doi:10.1021/acs.biomac.9b01255

Cited by 28 publications

(17 citation statements)

References 67 publications

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“…Scaffolds composed of biodegradable synthetic polymers are promising alternatives owing to the ability to control their degradation and mechanical properties . Poly(lactide- co -glycolide) (PLGA), polylactic acid (PLA), polycaprolactone (PCL), polyurethane (PU), and poly(glycerol sebacate) (PGS) are examples of biodegradable synthetic polymers proposed for small-diameter vessels grafts. − In fact, these scaffolds must be durable enough to withstand the physiological conditions without the risk of collapse or premature degradation until the formation of a new tissue in vivo. , Mechanical properties of human healthy blood vessels have been extensively reported in the literature, as illustrated in Table , which resumes Young’s modulus and maximum stress values measured for some native blood vessels. Therefore, these values can be used as target properties for the development of new and functional vascular grafts.…”

Section: Introductionmentioning

confidence: 99%

Tubular Fibrous Scaffolds Functionalized with Tropoelastin as a Small-Diameter Vascular Graft

et al. 2020

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Cardiovascular disorders are a healthcare problem in today's society. The clinically available synthetic vascular grafts are thrombogenic and could induce intimal hyperplasia. Rapid endothelialization and matched mechanical properties are two major requirements to be considered when designing functional vascular grafts. Herein, an electrospun tubular fibrous (eTF) scaffold was biofunctionalized with tropoelastin at the luminal surface. The luminal surface functionalization was confirmed by an increase of the zeta potential and by the insertion of NH 2 groups. Tropoelastin was immobilized via its −NH 2 or −COOH groups at the activated or aminolysed eTF scaffolds, respectively, to study the effect of exposed functional groups on human endothelial cells (ECs) behavior. Tensile properties demonstrated that functionalized eTF scaffolds presented strength and stiffness within the range of those of native blood vessels. Tropoelastin immobilized on activated eTF scaffolds promoted higher metabolic activity and proliferation of ECs, whereas when immobilized on aminolysed eTF scaffolds, significantly higher protein synthesis was observed. These biofunctional eTF scaffolds are a promising small-diameter vascular graft that promote rapid endothelialization and have compatible mechanical properties.

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Section: Introductionmentioning

confidence: 99%

Tubular Fibrous Scaffolds Functionalized with Tropoelastin as a Small-Diameter Vascular Graft

et al. 2020

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“…Eilenberg et al 103 created their single‐layer electrospun scaffolds (1.8 mm inner diameter) from a biodegradable poly(carbonate urethane) synthesized from PHC soft segment, hexamethylene diisocyanate (HMDI) hard segment, and bis(3‐hydroxypropyl) carbonate chain extender 104 . Using the same infrarenal rat model, these TEVGs were implanted without prior cell seeding.…”

Section: Pre‐clinical Applications Of Biodegradable Pu Scaffoldsmentioning

confidence: 99%

“…The results from Haskett et al show that 5 of 7 scaffolds implanted in rat descending aorta remained patent at the 8 weeks timepoint. Histology revealed structured neotissue formation in 3 of the 5 patent scaffolds and disorganized smooth muscle cell (SMC) growth in the remaining two.Eilenberg et al103 created their single-layer electrospun scaffolds (1.8 mm inner diameter) from a biodegradable poly(carbonate urethane) synthesized from PHC soft segment, hexamethylene diisocyanate (HMDI) hard segment, and bis(3-hydroxypropyl) carbonate chain extender 104. Using the same infrarenal rat model, these TEVGs were implanted without prior cell seeding.…”

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confidence: 99%

Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

Pedersen

Kim

Wagner

2022

J Biomedical Materials Res

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Early explorations of tissue engineering and regenerative medicine concepts commonly utilized simple polyesters such as polyglycolide, polylactide, and their copolymers as scaffolds. These biomaterials were deemed clinically acceptable, readily accessible, and provided processability and a generally known biological response. With experience and refinement of approaches, greater control of material properties and integrated bioactivity has received emphasis and a broadened palette of synthetic biomaterials has been employed. Biodegradable polyurethanes (PUs) have emerged as an attractive option for synthetic scaffolds in a variety of tissue applications because of their flexibility in molecular design and ability to fulfill mechanical property objectives, particularly in soft tissue applications. Biodegradable PUs are highly customizable based on their composition and processability to impart tailored mechanical and degradation behavior. Additionally, bioactive agents can be readily incorporated into these scaffolds to drive a desired biological response. Enthusiasm for biodegradable PU scaffolds has soared in recent years, leading to rapid growth in the literature documenting novel PU chemistries, scaffold designs, mechanical properties, and aspects of biocompatibility. Despite the enthusiasm in the field, there are still few examples of biodegradable PU scaffolds that have achieved regulatory approval and routine clinical use. However, there is a growing literature where biodegradable PU scaffolds are being specifically developed for a wide range of pathologies and where relevant pre‐clinical models are being employed. The purpose of this review is first to highlight examples of clinically used biodegradable PU scaffolds, and then to summarize the growing body of reports on pre‐clinical applications of biodegradable PU scaffolds.

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“…However, the development of grafts with an inner diameter of less than 6 mm which depict satisfying patency rates has remained a major challenge. Although several recent pre-clinical studies with biodegradable synthetic polymers [ [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] ], as well as natural extra-cellular matrices [ [12] , [13] , [14] , [15] , [16] , [17] ], or hybrids [ [18] , [19] , [20] ] yield hope for future clinical use, the goal to produce a long-term patent small diameter vascular graft (SDVG) remains unmet so far. Therefore, in this study, a home-made coating material derived from human placental chorionic plate was tested for its beneficial effect on endothelialization of ePTFE vascular grafts.…”

Section: Introductionmentioning

confidence: 99%

Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts

Rohringer

Schneider

Eder

et al. 2022

Materials Today Bio

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Hard Block Degradable Polycarbonate Urethanes: Promising Biomaterials for Electrospun Vascular Prostheses

Cited by 28 publications

References 67 publications

Tubular Fibrous Scaffolds Functionalized with Tropoelastin as a Small-Diameter Vascular Graft

Tubular Fibrous Scaffolds Functionalized with Tropoelastin as a Small-Diameter Vascular Graft

Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts

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