“…Among the diagnostic criteria of mental disorders, distress and disability can play at least three different roles (Amoretti and Lalumera 2019b). They can be used: (1) to make up for the current absence of relevant biomarkers or clinically useful measurements of severity, and thus to solve the threshold problem and distinguish between mental disorder and non-disorder, or between different mental disorders (this may be the case of anxiety disorders or neurocognitive disorders: these syndromes doubtless reflect a dysfunction, but it is unclear how one might assess their severity and establish the thresholds for demarcating normal and pathological anxieties, or mild and major neurocognitive disorders) 5 ; (2) to make up for the current lack of knowledge about the underlying dysfunction, and, again, to separate mental disorders from non-disorders (where the presence of a dysfunction is dubious, as with some paraphilic disorders, the harm criterion can provisionally be used to separate normal from pathological conditions); (3) to discriminate between those mental disorders that must be diagnosed and/ or medically treated and those mental disorders that should not (where the presence of a dysfunction is quite clear, as in the case of erectile disorder, the label of mental disorder should be applied; however, there might be good reasons not to diagnose or treat some of these conditions in practice, precisely when they are harmless).…”