Harmful impact of air pollution on severe acute exacerbation of chronic obstructive pulmonary disease: particulate matter is hazardous

Choi, Juwhan; Oh, Jee Youn; Lee, Young Seok; Min, Kyung Hoon; Hur, Gyu Young; Lee, Sung Yong; Kang, Kyung Ho; Shim, Jae Jeong

doi:10.2147/copd.s156617

Cited by 68 publications

(55 citation statements)

References 46 publications

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“…Most probably the hospitalized patients were more vulnerable to the detrimental effect of air pollutants than community dwellers as they were more seriously ill and remained exposed to the ambient air (e.g., housing style, occupation, protection awareness) might also be explained by the differences in disease severity and management (30). Emergency visits for AECOPD increased shortly (lag 1 day) after increased level of PM 2.5 (8,10) while, the association between hospital admissions for AECOPD was positive for both PM 10 and PM 2.5 on lag day3 as shown in previous studies (4,6,11,31,32).…”

Section: Discussionmentioning

confidence: 56%

Acute effects of air pollutants on daily mortality and hospitalizations due to cardiovascular and respiratory diseases

Pothirat¹,

Chaiwong²,

Liwsrisakun³

et al. 2019

J. Thorac. Dis

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is one of the districts in Chiang Mai, Thailand facing high level of seasonal air pollution every year, the exposure of community dwellers to outdoor air pollutants 24 hours a day during seasonal smog period because of their open-air housing style, and agricultural occupational hazard. In addition, Chiang Dao hospital is the only available hospital serving the community with open-air wards; therefore we could certainly to identify the association between air pollution and mortality of hospitalized patients. Thus, the aim of this study was to determine the association between daily average seasonal air pollutants and daily mortality of hospitalized patients and community dwellers as well as emergency and hospitalization visits for serious respiratory, cardiovascular, and cerebrovascular diseases. Methods: This time series study was conducted between 1 March 2016 and 31 March 2017. The association of various air pollutant concentrations including particulate matter diameter less than 10 and 2.5 microns (PM 10 and PM 2.5), sulfur dioxide (SO 2), nitrogen dioxide (NO 2), carbon monoxide (CO), ozone (O 3) and daily mortality of hospitalized patients and community dwellers as well as relationship with frequencies of serious respiratory, cardiovascular, and cerebrovascular diseases were analyzed using a general linear model with Poisson distribution. Results: Only PM 2.5 was found to be associated with increased daily mortality of hospitalized patients (lag day 6, adjusted RR =1.153, 95% CI: 1.001-1.329), whereas PM 10 , PM 2.5 , NO 2 , and O 3 were associated with increased daily non-accidental mortality of community dwellers (lag day 0-7, adjusted RR =1.006-1.040, 95% CI: 1.000-1.074). For acute serious respiratory events; PM 10 and PM 2.5 were associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), while SO 2 , CO, and O 3 were associated with emergency visits for community-acquired pneumonia (CAP). O 3 was associated with emergency visits for heart failure (HF), NO 2 with emergency visits for myocardial infarction (MI), and SO 2 with hospitalized visits for cerebrovascular accident (CVA). Conclusions: Seasonal air pollutants were found to be associated with higher mortality among hospitalized patients and community dwellers with varying effects on severe acute respiratory, cardiovascular, and cerebrovascular diseases.

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Section: Discussionmentioning

confidence: 56%

Acute effects of air pollutants on daily mortality and hospitalizations due to cardiovascular and respiratory diseases

Pothirat¹,

Chaiwong²,

Liwsrisakun³

et al. 2019

J. Thorac. Dis

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“…6 A meta-analyses suggest that PM exposure can increase COPD exacerbations, 2 7-9 and a recent study showed that PM and other air pollutants increased the risk of severe acute exacerbations. 10 Air pollutants can also Strength and limitations of this study ► This is the first prospective panel study conducted in Korea to assess the relationship between particulate matter (PM) exposure and symptoms, lung function, quality of life and exacerbations in patients with chronic obstructive pulmonary disease (COPD). ► A total of 120 patients from four different sites will be enrolled from three different areas of Korea to represent real-world air quality, accounting for regional differences in PM exposure.…”

Section: Introductionmentioning

confidence: 99%

Effect of particulate matter exposure on patients with COPD and risk reduction through behavioural interventions: the protocol of a prospective panel study

et al. 2020

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IntroductionPatients with chronic obstructive pulmonary disease (COPD) are vulnerable to particulate matter (PM) exposure which can increase acute exacerbations and hospitalisation. Interventions to avoid PM exposure are important but evidence-based guidance is lacking. This study aims to assess the impact of PM on lung function, quality of life and exacerbations in patients with COPD using a panel design study; it will also provide evidence for interventional measures to reduce harm from PM exposure.Methods and analysisA prospective panel study of patients with COPD aged ≥40 years will be conducted. Patients will be required to have a forced expiratory volume in one second <80% of the predicted value at enrolment. A total of 120 patients from three different regions will be enrolled, 60 from the metropolitan area, 30 from an industrialised area and 30 from a clean rural area. Clinical outcomes will be assessed through COPD assessment test scores, the St. George’s Respiratory Questionnaire for patients with COPD and pulmonary function testing. Indoor and outdoor PM in the patients’ environments will be measured using gravimetric and light scattering platforms. To estimate the individual dose of PM exposure, a time–activity diary, Geographic Information System and land use regression model will be combined in every season for 1 year. The correlation between PM exposure and the health status of patients with COPD will be evaluated. In addition, 40 patients with the lowest score of life behaviour score to reduce environmental PM exposure will be randomised to a control or intervention group, who will receive in-depth education on risk-reducing behaviours.Ethics and disseminationThis study was approved by the Institutional Review Board of each site. The participants received comprehensive information and provided informed consent. The result of this study will be discussed in the form of conference presentations and peer-reviewed publications.Trial registration numberNCT04020237.

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“…2015) reported the effects on central nervous system in infants and young children due to ozone and PM 10 . Additionally,Choi et al (2018) indicated that PM is hazardous for human health since is considered a major non-infectious cause of severe acute exacerbation of chronic obstructive pulmonary disease (COPD). The comparison of mass concentrations displayed inFigure 5shows that despite the efforts of Mexico City authorities, inhabitants remain exposed to PM 2.5 ; therefore, continuous studies related with monitoring and characterization of PM are necessary.…”

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confidence: 99%

A Study of PM2.5 Elemental Composition in Southwest Mexico City and Development of Receptor Models With Positive Matrix Factorization

Hernández-López

Miranda

Múgica-Álvarez

et al. 2020

RICA

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A study of elemental composition of PM2.5 samples collected at the main campus of the Universidad Nacional Autónoma de México, comprising data from 2015, 2016, and 2019, is described. X-ray fluorescence analysis was employed to measure concentrations of up to 19 elements, complemented with ion chromatography for eight ionic species (for samples of 2015 and 2016), and thermo-optical analysis for organic and elemental carbon (for samples of 2015). Positive matrix factorization (PMF) was applied to develop receptor models for each year, to identify polluting sources and their contributions to total mass. Five sources were identified in every case. With the aid of PMF, the influence of biomass burning on a major episode in May, 2019, was recognized. Comparisons with previous studies in this or nearby sites are also presented. It should be noted that only limited compositional data in this site are available since 2005 for the aerosol fine fraction.

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Harmful impact of air pollution on severe acute exacerbation of chronic obstructive pulmonary disease: particulate matter is hazardous

Cited by 68 publications

References 46 publications

Acute effects of air pollutants on daily mortality and hospitalizations due to cardiovascular and respiratory diseases

Acute effects of air pollutants on daily mortality and hospitalizations due to cardiovascular and respiratory diseases

Effect of particulate matter exposure on patients with COPD and risk reduction through behavioural interventions: the protocol of a prospective panel study

A Study of PM2.5 Elemental Composition in Southwest Mexico City and Development of Receptor Models With Positive Matrix Factorization

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