Harness-Shaped Distribution in Pediatric Tc-99m Tetrofosmin Scintigraphy

Comparison of Uptake of Multiple Clinical Radiotracers into Brown Adipose Tissue Under Cold-Stimulated and Nonstimulated Conditions

“…This tracer is taken up in normal mitochondria via passive or active transport into the cell (21)(22)(23), and images of this tracer represent the function of the mitochondria, their density, and tracer delivery, especially with longer uptake times. Fukuchi et al reported that high 99m Tc-MIBI uptake is seen in the cervical region of children, especially in winter (9), and suggested that 99m Tc-MIBI uptake into BAT was stimulated by cold temperatures. No significantly increased uptake was observed in our cold-activation model for 99m Tc-MIBI.…”

“…These results are consistent with the hypothesis that the increased incidence of high radiotracer uptake in BAT is related to activation of BAT. Fukuchi et al reported increased uptake of 99m Tc-tetrofosmin in BAT in pediatric patients (9). Higuchi et al described a patient who displayed high 99m Tc-sestamibi (MIBI) uptake in BAT but no uptake of 201 Tl-chloride (TlCl) in a dual-tracer SPECT study (10).…”