Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response

Ebrahimi, Nasim; Manavi, Mahdokht Sadat; Faghihkhorasani, Ferdos; Fakhr, Siavash Seifollahy; Baei, Fatemeh Jafari; Khorasani, Fereshteh Faghih; Zare, Mohammad Mehdi; Far, Nazanin Pazhouhesh; Rezaei-Tazangi, Fatemeh; Ren, Jun; Reiter, Russel J.; Nabavi, Noushin; Aref, Amir Reza; Chen, Chu; Ertas, Yavuz Nuri; Lu, Qi

doi:10.1007/s10555-023-10162-7

Cited by 15 publications

(3 citation statements)

References 211 publications

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“…In recent years, chemoresistance has been suggested as a main obstacle in the effective treatment of HCC (Wang, Wei, et al, 2020;Wang, Yu, et al, 2020). In general, tumor resistance to chemotherapeutics is categorized into acquired and intrinsic types (Ebrahimi et al, 2024). Acquired resistance is attributed to the molecular changes of cancer cells following therapy to improve cell survival (Ebrahimi, Far, et al, 2023;Ebrahimi, Fardi, et al, 2023;Ebrahimi, Hakimzadeh et al, 2023).…”

Section: Role In Chemoresistancementioning

confidence: 99%

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Arefnezhad,

Ashna,

Rezaei‐Tazangi

et al. 2024

Cell Biology International

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not been precisely defined so far. Hence, this review aimed to address the potential cross‐talk between noncoding RNAs (ncRNAs) and programmed cell death in HCC. All related papers in the English language up to June 2023 were collected and screened. The searched keywords in scientific databases, including Scopus, PubMed, and Google Scholar, were HCC, ncRNAs, Epigenetic, Programmed cell death, Autophagy, Apoptosis, Ferroptosis, Chemoresistance, Tumor recurrence, Prognosis, and Prediction. According to the reports, ncRNAs, comprising long ncRNAs, microRNAs, circular RNAs, and small nucleolar RNAs can affect cell proliferation, migration, invasion, and metastasis, as well as cell death‐related processes, such as autophagy, ferroptosis, necroptosis, and apoptosis in HCC by regulating cancer‐associated genes and signaling pathways, for example, phosphoinositide 3‐kinase/Akt, extracellular signal‐regulated kinase/MAPK, and Wnt/β‐catenin signaling pathways. It seems that ncRNAs, as epigenetic regulators, can be utilized as biomarkers in diagnosis, prognosis, survival and recurrence rates prediction, chemoresistance, and evaluation of therapeutic response in HCC patients. However, more scientific evidence is suggested to be accomplished to confirm these results.

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Section: Role In Chemoresistancementioning

confidence: 99%

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Arefnezhad,

Ashna,

Rezaei‐Tazangi

et al. 2024

Cell Biology International

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“… 13 Increasing evidence suggests that both EMT‐TFs such as Snail and Twist as well as EMT‐related signaling pathways including TGF‐β, Wnt, and Notch are correlated with the therapeutic resistance. 5 , 210 , 211 Here, we summarize the EMP‐induced resistance to chemotherapy and targeted therapy as well as the implications of EMP in immune evasion and immunotherapy resistance.…”

Section: Emp and Therapeutic Resistancementioning

confidence: 99%

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang,

Xue,

Pang

et al. 2024

MedComm

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Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor‐β, Wnt/β‐catenin, and Notch. However, due to the complicated nature of EMP, the diverse process of EMP is still not fully understood. In this review, we systematically conclude the biological background, regulating mechanisms of EMP as well as the role of EMP in therapy response. We also summarize a range of small molecule inhibitors, immune‐related therapeutic approaches, and combination therapies that have been developed to target EMP for the outstanding role of EMP‐driven tumor deterioration. Additionally, we explore the potential technique for EMP‐based tumor mechanistic investigation and therapeutic research, which may burst vigorous prospects. Overall, we elucidate the multifaceted aspects of EMP in tumor progression and suggest a promising direction of cancer treatment based on targeting EMP.

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“…2,3 Therefore, the establishment of novel therapies that are both less harmful and more effective is one of the most intensely pursued goals of contemporary medicinal chemistry. 4,5 Understanding the molecular mechanisms that regulate growth and survival of tumor cells would provide insights into potential targets for drug design and synthesis. 6,7 Epidermal growth factor receptor (EGFR) is known to be the key regulator of many complex biological processes, including cell motility, cell cycle regulation as well as apoptosis activation and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Abd El-Lateef,

Bafail,

Alhalees

et al. 2024

RSC Adv.

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Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response

Cited by 15 publications

References 211 publications

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

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