Harnessing nanobiotechnology for cerebral ischemic stroke management

Tang, Lu; Fu, Cong; Zhang, Aining; Li, Xiyue; Cao, Yuqi; Feng, Jingwen; Dong, Haijuan; Wang, Wei

doi:10.1039/d2bm01790c

Cited by 15 publications

(5 citation statements)

References 150 publications

(176 reference statements)

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“…It is one of the main causes of death and disability. [14,15] Ischemic stroke is highly recurrent and seriously harmful, which may lead to visual and speech disorders, brain cell damage and necrosis, lasting neurological impairment, decreased quality of life, and even fatal. [16] Explore the ischemic cerebral apoplexy and the molecular mechanism of TMS, is extremely important to the study of targeted drugs.…”

Section: Discussionmentioning

confidence: 99%

Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis

Zhao,

Liu,

et al. 2024

Medicine

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Ischemic stroke refers to ischemic necrosis or softening of localized brain tissue. Transcranial magnetic stimulation (TMS) is a painless, noninvasive and green treatment method, which acts on the central nervous system through a pulsed magnetic field to assist in the treatment of central nervous system injury diseases. However, the role of Il1r2 and Tnfrsf12a in this is unknown. The ischemic stroke datasets GSE81302 and TMS datasets GSE230148 were downloaded from Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis (WGCNA) was performed. The construction and analysis of protein-protein interaction (PPI) network and functional enrichment analysis were performed. Draw heat map gene expression. Through the Comparative Toxicogenomics Database (CTD) to find the most relevant and core gene diseases. TargetScan was used to screen miRNAs regulating DEGs. A total of 39 DEGs were identified. According to gene ontology (GO) analysis results, in biological process (BP) analysis, they were mainly enriched in the positive regulation of apoptosis process, inflammatory response, positive regulation of p38MAPK cascade, and regulation of cell cycle. In cellular component (CC) analysis, they were mainly enriched in the cell surface, cytoplasm, and extracellular space. In Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, they were mainly enriched in nf-κB signaling pathway, fluid shear stress and atherosclerosis, P53 signaling pathway, TNF signaling pathway, and apoptosis. Among the enrichment items of metascape, negative regulation of T cell activation, hematopoietic cell lineage, positive regulation of apoptotic process, fluid shear stress and atherosclerosis were observed in GO enrichment items. Five core genes (Socs3, Irf1, Il1r2, Ccr1, and Tnfrsf12a) were obtained, which were highly expressed in ischemic stroke samples. Il1r2 and Tnfrsf12a were lowly expressed in TMS samples. CTD analysis found that the core gene (Socs3, Irf1 and Il1r2, Ccr1, Tnfrsf12a) and ischemic stroke, atherosclerosis, hypertension, hyperlipidemia, thrombosis, stroke, myocardial ischemia, myocardial infarction, and inflammation. Il1r2 and Tnfrsf12a are highly expressed in ischemic stroke, but lowly expressed in TMS samples.

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Section: Discussionmentioning

confidence: 99%

Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis

Zhao,

Liu,

et al. 2024

Medicine

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“…In addition, NDDSs can be utilized to load hydrophobic, hydrophilic, and gene-based drugs while also functioning as labeling probes for tracer imaging of ISs [93,94]. In the realm of advanced NDDSs for an ischemic stroke (IS), common types include polymers, inorganic nanoparticles, liposomes, and cell membrane-coated nanoparticles [95,96].…”

Section: Advanced Nddss For Issmentioning

confidence: 99%

Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke

Zhang,

Chen,

Chen

2024

Molecules

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In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic strokes account for a large percentage of strokes. A reperfusion injury in ischemic strokes is a complex cascade of oxidative stress, neuroinflammation, immune infiltration, and mitochondrial damage. Conventional treatments are ineffective, and the presence of the blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers are turning their attention to nano-drug delivery systems. Functionalized nano-drug delivery systems have been widely studied and applied to the study of cerebral ischemic diseases due to their favorable biocompatibility, high efficiency, strong specificity, and specific targeting ability. In this paper, we briefly describe the pathological process of reperfusion injuries in strokes and focus on the therapeutic research progress of nano-drug delivery systems in ischemic strokes, aiming to provide certain references to understand the progress of research on nano-drug delivery systems (NDDSs).

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“…These advancements enable neuroprotection, anti-inflammation, thrombolysis, and blood–brain barrier penetration. By discussing the design and potential of nanobiotechnology, this report provides insights and future perspectives for effective management of ischemic stroke [ 89 ].…”

Section: Strokementioning

confidence: 99%

Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

2023

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Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally. Despite significant advancements in the development of pharmacological therapies, the challenges of targeted drug delivery to the cardiovascular system persist. Innovative drug-delivery systems have been developed to address these challenges and improve therapeutic outcomes in CVDs. This comprehensive review examines various drug delivery strategies and their efficacy in addressing CVDs. Polymeric nanoparticles, liposomes, microparticles, and dendrimers are among the drug-delivery systems investigated in preclinical and clinical studies. Specific strategies for targeted drug delivery, such as magnetic nanoparticles and porous stent surfaces, are also discussed. This review highlights the potential of innovative drug-delivery systems as effective strategies for the treatment of CVDs.

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Harnessing nanobiotechnology for cerebral ischemic stroke management

Abstract: This review highlights the recent achievements of nanobiotechnology for cerebral ischemic stroke management based on its pathophysiologic features.

Cited by 15 publications

References 150 publications

Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis

Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis

Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke

Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

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