2021
DOI: 10.3390/ijms22084239
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Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?

Abstract: Diabetes is a chronic metabolic disease caused by an absolute or relative deficiency in functional pancreatic β-cells that leads to defective control of blood glucose. Current treatments for diabetes, despite their great beneficial effects on clinical symptoms, are not curative treatments, leading to a chronic dependence on insulin throughout life that does not prevent the secondary complications associated with diabetes. The overwhelming increase in DM incidence has led to a search for novel antidiabetic ther… Show more

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Cited by 4 publications
(2 citation statements)
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References 122 publications
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“…Enzymatic digestion, controlled gentle mechanical shear, purification, and culture is the established approach to preparation of a final enriched islet cell product that is considered safe for intra-portal infusion of the recipient's liver [55]. The problem, however, is still obtaining cells for transplantation, as well as their protection against destruction processes after transplantation [56][57][58][59]. Recently, an extensive discussion of methods for harvesting cells in animal models has also been presented [60,61].…”
Section: Pancreas Transplantsmentioning
confidence: 99%
“…Enzymatic digestion, controlled gentle mechanical shear, purification, and culture is the established approach to preparation of a final enriched islet cell product that is considered safe for intra-portal infusion of the recipient's liver [55]. The problem, however, is still obtaining cells for transplantation, as well as their protection against destruction processes after transplantation [56][57][58][59]. Recently, an extensive discussion of methods for harvesting cells in animal models has also been presented [60,61].…”
Section: Pancreas Transplantsmentioning
confidence: 99%
“…5 , 6 While successful methods have been developed to replace β-islet cells through transplantation or regenerative therapies, the islet cells remain susceptible to attack by autoreactive T cells. 8 , 9 Thus, an effective cure for T1D would require pancreatic islet cell replacement, as well as inhibition of autoreactive T cells, while sparing pathogen- and tumor-specific T cells.…”
Section: Introductionmentioning
confidence: 99%