Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice

Wei, Siying; Li, Chenchen; Luo, Xia; Yang, Lanzexin; Liu, Yu; Wang, Qintao; Meng, Zhuo-Xian; Wang, Tao; Chen, Yan

doi:10.1016/j.scib.2021.12.024

Cited by 12 publications

(8 citation statements)

References 40 publications

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“… 162 Both total protein restriction and particular amino acid restriction stimulate FGF21 secretion in the liver and adipose tissue to augment energy expenditure and improve insulin sensitivity. 163 , 164 In responses to protein restriction, FGF21 plays an important role in diverse species, including humans. Long-term protein restriction stimulates the release of FGF21 in hepatocytes and elevates circulatory levels in male C57BL/6J mice and Sprague Dawley rats.…”

Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

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Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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“…To address our hypothesis, we acquired the single-cell data of pancreatic β islet cells from GEO (https://www.ncbi.nlm.nih.gov/geo/, accessed on 25 October 2023) using the accession number GSE165267, which is processed by Wei et al [108]. This dataset was analyzed using Seurat software v4.1.1 [109] implemented in R v4.2.1.…”

Section: Single-cell Data From Db/db Mice Pancreatic Islet Cellsmentioning

confidence: 99%

Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications

Begum,

Choubey,

Tirumalasetty

et al. 2023

Life

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Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, presents a formidable global health challenge with its associated complications. Adiponectin, an adipocyte-derived hormone, has emerged as a significant player in glucose metabolism and insulin sensitivity. Beyond its metabolic effects, adiponectin exerts anti-inflammatory, anti-oxidative, and vasoprotective properties, making it an appealing therapeutic target for mitigating diabetic complications. The molecular mechanisms by which adiponectin impacts critical pathways implicated in diabetic nephropathy, retinopathy, neuropathy, and cardiovascular problems are thoroughly examined in this study. In addition, we explore possible treatment options for increasing adiponectin levels or improving its downstream signaling. The multifaceted protective roles of adiponectin in diabetic complications suggest its potential as a novel therapeutic avenue. However, further translational studies and clinical trials are warranted to fully harness the therapeutic potential of adiponectin in the management of diabetic complications. This review highlights adiponectin as a promising target for the treatment of diverse diabetic complications and encourages continued research in this pivotal area of diabetes therapeutics.

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“…Several intermittent fasting patterns Downloaded from http://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20222151/942443/bsr-2022-2151c-t.pdf by guest on 06 February 2023 including fasting-mimicking diet (FMD) or leucine deprivation can increase β cell proliferation rate with a higher expression of Ki-67 in db/db mouse models to improve insulin sensitivity and β cell function or increase β cell mass [45; 86]. What's more, intermittent protein restriction for 4 weeks can also increase β cell replication in pancreatic islets to improve β cell mass and function which was verified by single-cell sequencing to have an elevated expression of cell cycle-related genes [57]. Although the increase of proliferation rate of β cells by intermittent protein restriction are not robust, this dietary strategy could potentially prevent the continuous loss of β cell mass occurring in T2D.…”

Section: Improvement Of β Cells In Pancreatic Islets By Nutritional I...mentioning

confidence: 99%

“…Intermittent protein restriction (IPR), which is similar to amino acid restriction, refers to a cycle of certain days of 5% daily protein consumption followed by ad libitum for the rest of time. Recently, four cycles IPR was found to reduce the hyperglycemia in diabetic mice and increase the cell number and function in pancreatic islets [ 57 ]. Mediterranean and DASH diet emphasize the consumption of plant-based foods and avoidance of animal-based food have been recently used in the treatment of patients with T2D [ 58 , 59 ].…”

Section: Different Nutritional Strategies For Diabetes Interventionmentioning

confidence: 99%

Nutritional strategies for intervention of diabetes and improvement of β-cell function

et al. 2023

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Diabetes mellitus, especially type 2 diabetes (T2D), is caused by multiple factors including genetics, diets and lifestyles. Diabetes is a chronic condition and is among the top 10 causes of death globally. Nutritional intervention is one of the most important and effective strategies for T2D management. It is well known that most of intervention strategies can lower blood glucose level and improve insulin sensitivity in peripheral tissues. However, the regulation of pancreatic b cells by dietary intervention is not well characterized. In this review, we summarized some of the commonly used nutritional methods for diabetes intervention. We then discussed the effects and the underlying mechanisms of nutritional intervention in improving the cell mass and function of pancreatic islet b cells. With emerging intervention strategies and in-depth investigation, we are expecting to have a better understanding about the effectiveness of dietary interventions in ameliorating T2D in the future.

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Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice

Cited by 12 publications

References 40 publications

Dietary regulation in health and disease

Dietary regulation in health and disease

Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications

Nutritional strategies for intervention of diabetes and improvement of β-cell function

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