Harnessing the Natural Healing Power of Colostrum: Bovine Milk‐Derived Extracellular Vesicles from Colostrum Facilitating the Transition from Inflammation to Tissue Regeneration for Accelerating Cutaneous Wound Healing

et al. 2022

Pharmaceutics

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In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage.

Section: Skin Elasticity Improvement Effect Of Col M-exo On Fibroblastssupporting

confidence: 91%

Section: Skin Elasticity Improvement Effect Of Col M-exo On Fibroblastssupporting

confidence: 91%

The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells

Han

et al. 2022

Pharmaceutics

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“…Oral ingestion of bovine colostrum particularly showed no side effects in clinical research even on repeated application of high doses, except lactose intolerance ( Struff and Sprotte, 2008 ). Moreover, milk-derived exosomes have a very high yield compared to animal cell-derived exosomes, which has economic advantages for drug commercialization ( Kim et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

Jang

et al. 2022

Front. Cell Dev. Biol.

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Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells. In this paper, we suggested exosomes derived from bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for hair loss. Results showed that Milk-exo promoted the proliferation of hair DP cells and rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest of follicle development. Milk-exo also induced dorsal hair re-growth in mice at the level comparable to minoxidil treatment, without associated adverse effects such as skin rashes. Our data demonstrated that Milk-exo accelerated the hair cycle transition from telogen to anagen phase by activating the Wnt/β-catenin pathway. Interestingly, Milk-exo has been found to stably retain its original properties and efficacy for hair regeneration after freeze-drying and resuspension, which is considered critical to use it as a raw material applied in different types of alopecia medicines and treatments. Overall, this study highlights a great potential of an exosome from colostrum as a therapeutic modality for hair loss.

“…Bovine colosEVs also showed shared effects with the mEVs that were mediated by the inflammatory immune regulation, thereby improving colitis symptoms in a mouse model [ 197 ]. The capacity to reduce inflammation could be useful also in wound healing, for which colosEVs shifted the inflammatory process to fibroblast proliferation, migration, and endothelial tube formation, thereby accelerating the wound recovery [ 198 ]. Like bovine mEVs, cow colosEVs were able to shape the microbiota; this was correlated with bone remodelling and partial recovery in an osteoporosis mouse model [ 199 ].…”

Section: Intrinsic Therapeutic Potential Of Mevsmentioning

confidence: 99%

Extracellular Vesicles from Animal Milk: Great Potentialities and Critical Issues

Mecocci

Trabalza‐Marinucci

Cappelli

2022

Animals

Other than representing the main source of nutrition for newborn mammals, milk delivers a sophisticated signaling system from mother to child that promotes postnatal health. The bioactive components transferred through the milk intake are important for the development of the newborn immune system and include oligosaccharides, lactoferrin, lysozyme, α-La, and immunoglobulins. In the last 15 years, a pivotal role in this mother-to-child exchange has been attributed to extracellular vesicles (EVs). EVs are micro- and nanosized structures enclosed in a phospholipidic double-layer membrane that are produced by all cell types and released in the extracellular environment, reaching both close and distant cells. EVs mediate the intercellular cross-talk from the producing to the receiving cell through the transfer of molecules contained within them such as proteins, antigens, lipids, metabolites, RNAs, and DNA fragments. The complex cargo can induce a wide range of functional modulations in the recipient cell (i.e., anti-inflammatory, immunomodulating, angiogenetic, and pro-regenerative modulations) depending on the type of producing cells and the stimuli that these cells receive. EVs can be recovered from every biological fluid, including blood, urine, bronchoalveolar lavage fluid, saliva, bile, and milk, which is one of the most promising scalable vesicle sources. This review aimed to present the state-of-the-art of animal-milk-derived EV (mEV) studies due to the exponential growth of this field. A focus on the beneficial potentialities for human health and the issues of studying vesicles from milk, particularly for the analytical methodologies applied, is reported.