Has India met this enemy before? From an eternal optimist’s perspective: SARS-CoV-2

Mehta, Prashant G.; Parikh, Purvish M.; Aggarwal, Sandeep; Batra, Atul; Patel, Arvind; Kulkarni, Padmaj; Sahoo, Ranjit Kumar; Gupta, Vineet; Bahl, Charu; Kumar, Rohit; Pabbi, Swati; Sharma, Anusha

doi:10.25259/ijms_30_2020

Cited by 13 publications

(14 citation statements)

References 5 publications

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“…That study was initiated mainly due to the small number of confirmed cases of COVID-19 at the African region with high malaria-prevalence ( references 4–6 of ( Iesa et al., 2020 )). This lower incidence was highlighted in an earlier study as well ( references 1,2 of ( Mehta et al., 2020 )). The presence of zoonotic viral genome in P. vivax ( Charon et al., 2019 ), which was pointed also by others ( De Souza, 2020 ), was mentioned as a basis of related work ( Mehta et al., 2020 ).…”

Section: Introductionsupporting

confidence: 54%

“…This lower incidence was highlighted in an earlier study as well ( references 1,2 of ( Mehta et al., 2020 )). The presence of zoonotic viral genome in P. vivax ( Charon et al., 2019 ), which was pointed also by others ( De Souza, 2020 ), was mentioned as a basis of related work ( Mehta et al., 2020 ). Also, one case study reported co-infection with COVID-19 and P. vivax in a 10-year-old boy ( Kishore et al., 2020 ).…”

Section: Introductionsupporting

confidence: 54%

“…Yet, re-infection with P. vivax simultaneously with COVID-19 or a relapse in its natural course was not ruled out. However, incidences of malaria and SARS-CoV-2 were found to have a negative correlation ( Mehta et al., 2020 ). The genomic similarity between various strains of SARS-CoV-2 and the matryoshka RNA virus 1 (MaRNAV-1), associated with P. vivax , was also investigated ( Charon et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Adıgüzel

2021

Acta Tropica

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Aim This study is looking for a common pathogenicity between SARS-CoV-2 and Plasmodium species, in individuals with certain HLA serotypes. Methods 1 . Tblastx searches of SARS-CoV-2 are performed by limiting searches to five Plasmodium species that infect humans. 2 . Aligned sequences in the respective organisms’ proteomes are searched with blastp. 3 . Binding predictions of the identified SARS-CoV-2 peptide to HLA supertype representatives are performed. 4 . Blastp searches of predicted epitopes that bind strongly to the identified HLA allele are performed by limiting searches to H. sapiens and Plasmodium species, separately. 5 . Peptides with minimum 60% identity to the predicted epitopes are found in results. 6 . Peptides among those, which bind strongly to the same HLA allele, are predicted. 7 . Step- 4 is repeated by limiting searches to H. sapiens , followed by the remaining steps until step- 7 , for peptides sourced by Plasmodium species after step -6 . Results SARS-CoV-2 peptide with single letter amino acid code CFLGYFCTCYFGLFC has the highest identity to P. vivax . Its YFCTCYFGLF part is predicted to bind strongly to HLA-A*24:02. Peptides in the human proteome both homologous to YFCTCYFGLF and with a strong binding affinity to HLA-A*24:02 are YYCARRFGLF, YYCHCPFGVF, and YYCQQYFFLF. Such peptides in the Plasmodium species’ proteomes are FFYTFYFELF, YFVACLFILF, and YFPTITFHLF. The first one belonging to P. falciparum has a homologous peptide (YFYLFSLELF) in the human proteome, which also has a strong binding affinity to the same HLA allele. Conclusion Immune responses to the identified-peptides with similar sequences and strong binding affinities to HLA-A*24:02 can be related to autoimmune response risk in individuals with HLA-A*24:02 serotypes, upon getting infected with SARS-CoV-2 or P. falciparum .

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Section: Introductionsupporting

confidence: 54%

Section: Introductionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Adıgüzel

2021

Acta Tropica

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“…Mankind has, more often than not, been at the receiving end of certain unprecedented events that have hogged the limelight and become history [1]. Diseases which were never there in the past have gained currency and become a part of the popular parlance.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 pandemic and its recovery time of patients in India: A pilot study

Barman

Rahman

Bora

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background and aims: Covid-19 virus started from Wuhan, China and has brought the world down to its knees. It has catapulted as a venomous global phenomenon. This study focuses on the Covid-19 situation in India and its recovery time. Method: The study period is from March 1, 2020 to April 25, 2020. A random sample of 221 individuals found positive with Covid-19 from March 1, 2020 to 31st March is included in the study which is followed up April 25, 2020. There is a male preponderance in the sample with 66% of the Covid-19 patients being male and about 34% being female. Kaplan-Meier Product limit estimator, Kaplan-Meier survival curve and Log-rank test are used to analyze the recovery time of Covid-19 patients. Result: From the results of the study, it is found that the average recovery time of Covid-19 patients in India is 25 days (95% C.I. 16 days to 34 days). Only 4% of the patients get cured after 10 days of treatment. The recovery time of male and female patients is not statistically different. Recovery time of patients belonging to different age groups is also not statistically significant. Conclusion: This information on recovery time of Covid-19 patients will help planners to chalk out effective strategies.

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“…[ 3 ] Specifically, there is a lot of criticism regarding the adequacy of testing and whether all the cases are being detected. [ 4 ]…”

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confidence: 99%

COVID-19 testing in India in comparison to the rest of the world. If Indian testing strategy was replicated in the other top 15 COVID-19 affected countries in the world, the status would be startlingly different

Parikh

Bapna

Krishna³

et al. 2020

IJMS

Self Cite

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In terms of the absolute number of COVID-19 positive cases, India is among the top four countries in the world. There is a lot of unwarranted criticism about the alleged inadequacy of COVID-19 testing in India. The facts available from international and publicly available online non-government source covering the entire world show otherwise. While India is fourth in terms of an absolute number of cases, its rank is 132nd in terms of cases per million population and 107th for deaths per million population. These are indications that India is doing much better in the battle against COVID-19 than it is getting credit for. The correct benchmark for the adequacy of testing is the percentage of COVID-19 positive results as compared to the total number of tests performed. India ranks 5th (out of 215) in this respect – being better than some western countries such as the USA, Spain, and France. Thus, the Indian strategy for COVID-19 testing is better and more appropriate than the majority of other countries with the large absolute number of positive cases.

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Has India met this enemy before? From an eternal optimist’s perspective: SARS-CoV-2

Cited by 13 publications

References 5 publications

Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

COVID-19 pandemic and its recovery time of patients in India: A pilot study

COVID-19 testing in India in comparison to the rest of the world. If Indian testing strategy was replicated in the other top 15 COVID-19 affected countries in the world, the status would be startlingly different

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