Topography can be directly observed, but what controls topographic variation is not readily known. To investigate a prominent and remarkably consistent along‐trend topographic gradient belt (TGB) in intraplate eastern China and its connection to ongoing deformation and geodynamics, we examine the regional density structure of the crust and mantle lithosphere. We first use S velocities to derive an initial density and then refine the density model by joint inversion of topography and gravity. We use the final density model and receiver functions to strip away topographic contributions from the crust, and we subsequently estimate the thickness of the mantle lithosphere required to satisfy flexural isostasy. Crustal buoyancy overcompensates for the elevation change across the TGB. East of the TGB (eastern north China craton and southeastern south China), the lithosphere is thin (~ 90 km), suggesting that not only the eastern north China craton but also much of the eastern China has experienced lithospheric dismemberment. The TGB behaves as an important contour for the lithospheric thickness, except for the northeast China and Qinling‐Dabie. Proposed refertilization of the altered mantle lithosphere in the east side of TGB would result in even lower lithospheric thickness, while hydration and asthenosphere upwelling have the opposite effect. This systematic calculation gives a regional analysis of eastern China and could be a useful guide for the regions lacking seismic investigations.