Hashimoto's encephalopathy presenting with progressive cerebellar ataxia

Nakagawa, Hiroto; Yoneda, Makoto; Fujii, Akihiro; Kinomoto, Keiko; Kuriyama, Masaru

doi:10.1136/jnnp.2006.093005

Cited by 47 publications

(41 citation statements)

References 5 publications

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“…In regards to autoimmune cerebellar ataxia, GADantibody-positive cerebellar ataxia (13,14), gluten ataxia (15) and thyroid-antibody-positive cerebellar ataxia (16,17) …”

Section: In the Present Study Ivig Therapy Was Administered In Sevenmentioning

confidence: 99%

Intravenous Immunoglobulin Therapy for Autoantibody-Positive Cerebellar Ataxia

et al. 2009

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“…In regards to autoimmune cerebellar ataxia, GADantibody-positive cerebellar ataxia (13,14), gluten ataxia (15) and thyroid-antibody-positive cerebellar ataxia (16,17) …”

Section: In the Present Study Ivig Therapy Was Administered In Sevenmentioning

confidence: 99%

Intravenous Immunoglobulin Therapy for Autoantibody-Positive Cerebellar Ataxia

et al. 2009

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“…A similar case has been reported by Nakagawa and cols. (10). Necropsies of patients with hypothyroidism and cerebellar ataxia have been reported.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Ataxia as A Presenting Feature of Hypothyroidism

et al. 2016

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SUMMARYSymptoms and signs of the hypothyroidism vary in relation to the magnitude and acuteness of the thyroid hormone deficiency. The usual clinical features are constipation, fatigue, cold intolerance and weight gain. Rarely it can present with neurologic problems like reversible cerebellar ataxia, dementia, peripheral neuropathy, psychosis and coma. Hypothyroidism should be suspected in all cases of ataxia, as it is easily treatable. A 40 year-old male presented with the history facial puffiness, hoarseness of voice and gait-ataxia. Investigations revealed frank primary hypothyroidism. Anti-TPO antibody was positive. Thyroxine was started and patient improved completely within eight weeks. Hypothyroidism can present with ataxia as presenting feature. Hypothyroidism should be considered in all cases of cerebellar ataxia as it is a reversible cause of ataxia. Arch Endocrinol Metab. 2016;60(2):183-5

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“…Rarely, HE manifests as a cerebellopathy with or without encephalopathy (8)(9)(10). Diagnosis is based on elevated TPO Abs in patients with compatible clinical presentation after ruling out other conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Other less common presentations include chorea, cerebellopathy, and myelopathy (8)(9)(10). Early recognition and treatment of HE is crucial and in most cases reversible (3).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Resolution of Postpartum Hashimoto Encephalopathy with Levothyroxine Therapy Alone

Nehme

Kadhem

Ebrahem

et al. 2018

AACE Clinical Case Reports

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Objective: Hashimoto encephalopathy (HE) is an uncommon syndrome characterized by seizures, movement disorders, cognitive or neuropsychiatric symptoms associated with dysthyroidism, and elevated anti-thyroperoxidase antibodies. It is more prevalent in females and all age groups can be affected. While its pathophysiology remains unclear, it is commonly defined as a steroid-responsive condition. Rarely, HE manifests with cerebellar ataxia.Methods: We report the case of a 21-year-old female presenting with cerebellar HE after delivery spontaneously resolving without corticosteroid treatment.Results: This case adds to the limited data available on HE and challenges the common conception of HE as a steroid-responsive disease.Conclusion: While our case suggests that HE might spontaneously recover, it is too limited to be conclusive and further studies are needed to clearly define the mechanism, exacerbating factors, and treatment options. HE should be considered in patients with otherwise unexplained cerebellar ataxia. (AACE Clinical Case Rep. 2018;4:e13-e15) Abbreviations: HE = Hashimoto encephalopathy; TPO Abs = antithyroperoxidase antibodies

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Hashimoto's encephalopathy presenting with progressive cerebellar ataxia

Abstract: Hashimoto's encephalopathy presenting with progressive cerebellar ataxiaHashimoto's encephalopathy is an autoimmune encephalopathy that came to be regarded as a new clinical entity distinct from myxo-oedema encephalopathy, associated with Hashimoto's thyroiditis.

Cited by 47 publications

References 5 publications

Intravenous Immunoglobulin Therapy for Autoantibody-Positive Cerebellar Ataxia

Intravenous Immunoglobulin Therapy for Autoantibody-Positive Cerebellar Ataxia

Cerebellar Ataxia as A Presenting Feature of Hypothyroidism

Spontaneous Resolution of Postpartum Hashimoto Encephalopathy with Levothyroxine Therapy Alone

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