Haversian bone formation rates determined by a new method in a mastodon, and in human diabetes mellitus and osteoporosis

Wu, Kao; Schubeck, K. E.; Frost, Harold M.; Villanueva, A. R.

doi:10.1007/bf02196201

Cited by 126 publications

(93 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Evidence for reduced osteoblastic activity and osteopenia has been reported in type 1 diabetes (11)(12)(13)(14)48,49). The results of the present studies indicate that type 1 diabetes impairs intramembranous bone healing, as demonstrated by our finding that the degree of healing of circular osteotomies was reduced by 40% in diabetic animals versus nondiabetic controls.…”

Section: Discussionsupporting

confidence: 81%

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes

et al. 2003

View full text Add to dashboard Cite

The effect of type 1 diabetes on bone healing and bone formation in standardized craniotomy defects created in BALB/cByJ mice was determined. The hypothesis that advanced glycation end products (AGEs) contribute to diminished bone healing in diabetes was evaluated by assessing for the presence of the receptor for advanced glycation end products (RAGE) by immunohistochemistry in healing craniotomy defects in diabetic animals. The effect of local application of a known RAGE protein ligand, N ⑀ -(carboxymethyl)lysine (CML)؊mouse serum albumin (MSA), on craniotomy defect healing in normal animals was then assessed and compared to the effects of control MSA. Finally, evidence in support of the expression of RAGE mRNA and protein in osteoblastic cells was obtained. The results indicated that craniotomy defects in diabetic animals healed ϳ40% of the degree to which they healed in nondiabetic animals (P < 0.05). RAGE was expressed at higher levels in healing bone tissues in diabetic compared to control animals. Further studies in nondiabetic animals indicated that bone healing was reduced by 63 and 42% in lesions treated with 900 and 90 g CML-MSA, respectively, compared to in animals treated with MSA alone (P < 0.05). Evidence for the expression of RAGE was obtained in mouse and rat osteoblastic cultures. These results support the contribution of AGEs to diminished bone healing in type 1 diabetes, possibly mediated by RAGE. Diabetes

show abstract

Section: Discussionsupporting

confidence: 81%

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes

et al. 2003

View full text Add to dashboard Cite

show abstract

“…We observed the same trend of the remodeling space. The age-related increase in the number of intact and fragmentary os teons, previously recorded in the femur, tibia and fibula [32,33], and in the 6th rib [34], is also mainly dependent on the activation fre quency [31]. Many factors such as interperson variability, local differences, osteon size, and even random temporary variations, can in fluence the activation frequency and thus the osteon population [31.…”

Section: Discussionmentioning

confidence: 99%

Structural Changes with Aging in Cortical Bone of the Human Tibia

Behets¹,

Duchesne²,

Dhem³

1997

Gerontology

View full text Add to dashboard Cite

Structural modifications are considered to play a significant role in the age-related alterations of bone quality and strength. Senescent compact bone is characterized by an increasing heterogeneity of aspects, including high numbers of lowly mineralized osteons as well as the presence of osteons with hypermineralized lamellae or with a notched haversian canal wall, and of double-zone osteons. These latter three types of osteons are different from the structures involved in the haversian remodeling. In the present study, blocks of midshaft tibia from 7 young men (18-39 years), 14 aged men (50-92 years) and 15 aged women (57-96 years) were embedded in methyl methacrylate in order to perform microradiographic and histomorphometric analysis of undecalcified sections. The intracortical porosity was higher in the aged men than in the young ones, as were the numbers of haversian structures and, to a lesser extent, the diameters of the haversian canals. The aged women showed the same tendency, with cortical porosity still higher than in the men. The osteons with hypermineralized lamellae, those with a notched canal and the double-zone osteons appear to constitute large subgroups of the total haversian population, even in the early adult life. Among them, only the osteons with a notched canal wall increased in frequency with age. The 3 types are much more numerous than the structures involved in the typical haversian remodeling. The correlations between their frequencies as well as their significant topographic association corroborates the hypothesis that the hypermineralized lamellae may crumble down because of their excessive brittleness, giving rise to the haversian canals with notched walls. These enlarged canals could be refilled-by bone apposition and result in the double-zone osteons. The 3 types of osteons could constitute different steps of one mechanism of bone desinte-gration and repair occurring very progressively, which might contribute to modify the bone quality and to increase the intracortical porosity.

show abstract

“…Kim et al (2007) and Wu et al (1970) directly stated that the number of osteons reaches its maximum at the age of 60 years, and individuals in the senilis age range can display degenerative changes that affect the results. However, it is difficult to determine whether the maximal number of osteons has been achieved, as the highest age of individuals analysed in this study was almost 50 years.…”

Section: Historical Materials Analyses (Methodological Issues)mentioning

confidence: 99%

Estimating age at death from an archaeological bone sample – a preliminary study based on comparison of histomorphometric methods

Mnich

Skrzat

Szostek

2017

Anthropological Review

View full text Add to dashboard Cite

The estimation of age at death is one of the most fundamental biological parameters, determined on skeletal remains in anthropological context. That is why, there is a constant need to improve applied methods. Histomorphometry, which uses microscopic analysis of bone tissue is suggested to be one alternative method. In general, this technique is based on measurements and the determination of the number and density of basic bone structural units, osteons. Osteon density is found to be related with age of the individual. The main goal of this research was to compare results of determined age at death, on the basis of ribs histology, comes from methods proposed by different authors. We analyzed ground cross sections of ribs from archeological origin. The presented methodology is simple in use and effective. Four different methods were tested (Stout and Paine 1992;Cho et al. 2002;Kim et al. 2007;Bednarek et al. 2009). The obtained age results were compared with each other as well as related to the age estimated by standard macroscopic method used in anthropology. Bednarek's method is recognized to be the most supportive for anthropological analyzes. Methodological issues connected with grinding methodology and results interpretation are also presented. Hypothesis about interpopulation as well as histological and dimorphic differences were confirmed.

show abstract

Haversian bone formation rates determined by a new method in a mastodon, and in human diabetes mellitus and osteoporosis

Cited by 126 publications

References 5 publications

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes

Structural Changes with Aging in Cortical Bone of the Human Tibia

Estimating age at death from an archaeological bone sample – a preliminary study based on comparison of histomorphometric methods

Contact Info

Product

Resources

About