Hazardous ecotoxicological impact of two commonly used nitrofuran-derived antibacterial drugs: Furazolidone and nitrofurantoin

Lewkowski, J.; Rogacz, Diana; Rychter, Piotr

doi:10.1016/j.chemosphere.2019.01.144

Cited by 42 publications

(18 citation statements)

References 36 publications

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“…Production in the furazolidone group was the smallest, which might relate to the toxicity of furazolidone. It was proved that furazolidone affected the absorption of water and soluble nutrients in mung bean sprouts [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, it might reduce the shortening effect of antimicrobials on the lengths of mung bean sprouts. The lengths of mung bean sprouts in the furazolidone group were the smallest, which might be associated with the toxicity of furazolidone in mung bean sprouts [ 31 ]. The bud and root lengths of mung bean sprouts in the enrofloxacin, olaquindox, doxycycline and furazolidone groups were obviously shortened, similar to those in the 6-BA group.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Typical Antimicrobials on Growth Performance, Morphology and Antimicrobial Residues of Mung Bean Sprouts

Cao

Wang

et al. 2022

Antibiotics

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Antimicrobials may be used to inhibit the growth of micro-organisms in the cultivation of mung bean sprouts, but the effects on mung bean sprouts are unclear. In the present study, the growth performance, morphology, antimicrobial effect and antimicrobial residues of mung bean sprouts cultivated in typical antimicrobial solutions were investigated. A screening of antimicrobial residues in thick-bud and rootless mung bean sprouts from local markets showed that the positive ratios of chloramphenicol, enrofloxacin, and furazolidone were 2.78%, 22.22%, and 13.89%, respectively. The cultivating experiment indicated that the production of mung bean sprouts in antimicrobial groups was significantly reduced over 96 h (p < 0.05). The bud and root length of mung bean sprouts in enrofloxacin, olaquindox, doxycycline and furazolidone groups were significantly shortened (p < 0.05), which cultivated thick-bud and rootless mung bean sprouts similar to the 6-benzyl-adenine group. Furthermore, linear regression analysis showed average optical density of 450 nm in circulating water and average production had no obvious correlation in mung bean sprouts (p > 0.05). Antimicrobial residues were found in both mung bean sprouts and circulating water. These novel findings reveal that the antimicrobials could cultivate thick-bud and rootless mung bean sprouts due to their toxicity. This study also proposed a new question regarding the abuse of antimicrobials in fast-growing vegetables, which could be a potential food safety issue.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effects of Typical Antimicrobials on Growth Performance, Morphology and Antimicrobial Residues of Mung Bean Sprouts

Cao

Wang

et al. 2022

Antibiotics

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“…Also, the breakdown or depletion of these compounds does not actually make them less lethal or harmless. For example, degradation of furazolidone biologically may lead to the formation and development of carcinogenic metabolites [71]. This further depicts the relevance of biochar application in removing them via the adsorption mechanism.…”

Section: Role Of Biochar In Pollution Managementmentioning

confidence: 94%

Sustainable Use of Biochar in Environmental Management

Abukari¹,

Imoro²,

Imoro³

et al. 2021

Environmental Health

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Conversion of agricultural wastes into eco-friendly and low cost biochar is not only a smart recycling strategy but a panacea to environmental pollution management. Agricultural wastes biochar can be an effective alternative technique for controlling contaminants due to its low cost, high-efficiency, simple to use, ecological sustainability and reliability in terms of public safety. Biochars have made substantial breakthroughs in reducing greenhouse gases emissions, reducing soil nutrient leaching, sequester atmospheric carbon into the soil, increasing agricultural productivity, and reducing bioavailability of environmental contaminants. Recent advances in the understanding of biochars warrant a proper scientific evaluation of the relationship between its properties and impact on soil properties, environmental pollutant remediation, plant growth, yield, and resistance to biotic and abiotic stresses. The main factors controlling biochar properties include the nature of feedstock, heat transfer rate, residence time and pyrolysis temperature. Biochar efficacy in pollutants management largely depends on its elemental composition, ion-exchange capacity, pore size distribution and surface area, which vary with the nature of feedstock, preparation conditions and procedures. The chapter explored the possibility of using biochar from agricultural wastes as a suitable alternative for the remediation of environmental pollutants, soil conditioning and the long-term biochar application in the environment.

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“…Lewkowski et al investigated the effect of furazolidone on growth of oat, radish Sativus, and Alivibrio fischeri bacteria. Their results indicated that furazolidone is very toxic to Alivibrio fischeri with an EC 50 of 2.05 mg/L [45]. The accumulation of furazolidone metabolites have been reported in the literature [5]; its use is prohibited by the Food and Drug Administration due to being a nitrofuran compound and inhibiting monoamine oxidase [46].…”

Section: Nitrofuransmentioning

confidence: 99%

A Review on the Main Antibiotic Drugs Used in Fish Farming: Ecotoxicity, Characterization and Remediation

2021

Aquac Fish Stud

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Aquaculture is a growing industry with a high demand mainly due to its significant contribution to the food sector. One of the main challenges of aquaculture is the prevention and treatment of fish diseases through the extensive application of antibiotics. However, information on the various consequences of pharmaceuticals in fish farms remains limited to this day. Based on the existing scientific literature, this report aims to give an overview of the most commonly used antibiotics in aquaculture, which belong to the groups of quinolones, sulfonamides, tetracyclines, amphenicols and macrolides. This review paper summarizes the information available on the characterization, ecotoxicology and application of florfenicol, erythromycin, furazolidone, oxolinic acid, ciprofloxacin, ofloxacin, sulfadiazine, sulfadimethoxine, sulfamethoxazole, oxytetracycline and tetracycline.

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Hazardous ecotoxicological impact of two commonly used nitrofuran-derived antibacterial drugs: Furazolidone and nitrofurantoin

Cited by 42 publications

References 36 publications

Effects of Typical Antimicrobials on Growth Performance, Morphology and Antimicrobial Residues of Mung Bean Sprouts

Effects of Typical Antimicrobials on Growth Performance, Morphology and Antimicrobial Residues of Mung Bean Sprouts

Sustainable Use of Biochar in Environmental Management

A Review on the Main Antibiotic Drugs Used in Fish Farming: Ecotoxicity, Characterization and Remediation

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