Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet

Hatipoglu, Aydan; Kanbagli, Öznur; Balkan, Jale; Küçük, Mutlu; Çevikbaş, Uğur; Aykaç‐Toker, Gülçin; Berkkan, Hakan; Uysal, Müjdat

doi:10.1271/bbb.68.2050

Cited by 28 publications

(22 citation statements)

References 36 publications

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“…They also demonstrated that almond pellicle flavonoids act in synergy with vitamins C and E. Hatipoglu et al (2004) investigated the effect of hazelnut oil on prooxidant-antioxidant status in rabbits fed a highcholesterol diet. As expected, a high-cholesterol diet significantly increased lipid and lipid peroxide levels in the plasma, liver and aorta and led to histopathological atherosclerotic changes in the aorta.…”

Section: Protective Effects Of Nut Antioxidants On Ldl Oxidation In Imentioning

confidence: 99%

“…Anderson et al (2001) used polyphenol-rich extracts from English walnuts and ellagic acid and studied both their ability to inhibit LDL oxidation in vitro and their effects on LDL alpha-tocopherol during oxidative stress: 2,2'-Azobis'(2-amidino propane) hydrochloride-induced LDL oxidation was significantly inhibited by 87 and 38 % with the highest concentration (1·0 micromol/l) of ellagic acid and walnut Chen et al (2005) demonstrated that almond-pellicle flavonoids have a relatively high bioavailability in hamsters and increase the resistance of copper-mediated LDL in vitro and ex vivo. They also demonstrated that almond pellicle flavonoids act in synergy with vitamins C and E. Hatipoglu et al (2004) investigated the effect of hazelnut oil on prooxidant-antioxidant status in rabbits fed a highcholesterol diet. As expected, a high-cholesterol diet significantly increased lipid and lipid peroxide levels in the plasma, liver and aorta and led to histopathological atherosclerotic changes in the aorta.…”

Section: Protective Effects Of Nut Antioxidants On Ldl Oxidation In Imentioning

confidence: 99%

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Health benefits of nuts: potential role of antioxidants

et al. 2006

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A diet rich in fruits, vegetables and minimally refined cereals is associated with lower risk for chronic degenerative diseases. Since oxidative stress is common in chronic degenerative disease, it has been assumed that dietary antioxidants may explain this protective effect. Every dietary plant contains numerous types of antioxidants with different properties. Many of these antioxidants cooperate in oxidative stress reduction in plants, and we hypothesize that many different antioxidants may also be needed for the proper protection of animal cells. To test this hypothesis, it is useful to identify dietary plants with high total antioxidant content. Several nuts are among the dietary plants with the highest content of total antioxidants. Of the tree nuts, walnuts, pecans and chestnuts have the highest contents of antioxidants. Walnuts contain more than 20 mmol antioxidants per 100 g, mostly in the walnut pellicles. Peanuts (a legume) also contribute significantly to dietary intake of antioxidants. These data are in accordance with our present extended analysis of an earlier report on nut intake and death attributed to various diseases in the Iowa Women's Health Study. We observed that the hazard ratio for total death rates showed a U-shaped association with nut/peanut butter consumption. Hazard ratio was 0·89 (CI ¼ 0·81 -0·97) and 0·81 (CI ¼ 0·75 -0·88) for nut/peanut butter intake once per week and 1-4 times per week, respectively. Death attributed to cardiovascular and coronary heart diseases showed strong and consistent reductions with increasing nut/peanut butter consumption. Further studies are needed to clarify whether antioxidants contribute to this apparent beneficial health effect of nuts. Nuts: Antioxidants: LDL oxidation: Flavonoids: FRAP: Antioxidant defence: Oxidative damageNuts are not easily defined in a manner that would be both compatible with popular usage and acceptable to botanists. For example, the groundnut or peanut is a legume, and the chufa nut, which is common in south Europe and Africa, is a tuber. Some languages such as French, even lack an umbrella word equivalent to nuts. 'Noix' in French looks like one, but just means walnuts. In this text we will not only include botanically defined nuts, but will also include data on some foods which have traditionally been defined as nuts.Nuts are highly nutritious and of prime importance for people in several regions in Asia and Africa. Most nuts contain a great deal of fat (e.g. pecan 70 %, macadamia nut 66 %, Brazil nut 65 %, walnut 60 %, almonds 55 % and peanut butter 55 %). Most have a good protein content (in the 10 -30 % range), and only a few have a very high starch content (Davidson, 1999). Recently, many nuts have also been identified as especially rich in antioxidants (Halvorsen et al. 2002;Wu et al. 2004). Nuts therefore constitute one of the most nutritionally concentrated kinds of food available. Most nuts, left in their shell, have a remarkably long shelf-life and can conveniently be stored for winter use.The aim of this paper is ...

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Section: Protective Effects Of Nut Antioxidants On Ldl Oxidation In Imentioning

confidence: 99%

Section: Protective Effects Of Nut Antioxidants On Ldl Oxidation In Imentioning

confidence: 99%

Health benefits of nuts: potential role of antioxidants

et al. 2006

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“…The clinical studies suggested that the supplementation of human diet with hazelnuts, walnuts or pistachios is beneficial for the amelioration of blood plasma antioxidant potential and lipid profiles that are closely related to cardiovascular risks (Edwards et al, 1999;Durak et al, 1999;Tapsell et al, 2004;Koçyigit et al, 2006;Lavedrine et al, 1999). The consumption of the oils of the indicated nuts also has beneficial effects on improvement of blood lipid profiles and/or reduction of lipid peroxide levels (Lavedrine et al, 1999;Balkan et al, 2003;Zibaeenezhad et al, 2003;Hatipoglu et al, 2004). Recently, some of the health-related phenolic compounds in nuts have been identified.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and phenolic content of fresh and dry nuts with or without the seed coat

Arcan

Yemenicioğlu

2009

Journal of Food Composition and Analysis

123

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Total antioxidant activities based on ABTS free radical scavenging activity and phenolic content of fresh or dry hazelnuts, walnuts and pistachios assayed with their seed coats changed between 3063 and 11,076 μmol trolox equivalents/100 g d.w. and 256 and 755 mg gallic acid equivalents/100 g d.w., respectively. The walnuts used in this study showed the highest antioxidant activity, followed by pistachios and hazelnuts. The removal of seed coat reduced the total antioxidant activity of hazelnuts, walnuts and pistachios almost 36, 90 and 55%, respectively. The total antioxidant activities of investigated fresh and dry nuts are not considerably different. However, phenolic content and antioxidant activity in hydrophilic and ethanolic fractions obtained by successive extraction of nuts showed some variation. The antioxidant activity in 1-serving portion of fresh or dry walnuts is equivalent to that in almost 2-serving portions of black tea, and 1.2-1.7-serving portions of green and Earl Grey tea. One-serving portions of dry hazelnuts and fresh or dry pistachios contained antioxidant activity equivalent to that in 0.7-1-serving portions of black tea. The antioxidant activity measurements correlated with phenolic content (r2 = 0.70). This study showed the potential of using fresh or dry nuts to develop functional foods with high antioxidant activity

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“…Various levels of dietary cholesterol (0.2-1.3%) have been used to create the disease experimentally [12,13] and concomitant administration of other potentially beneficial substances has been studied for periods varying from 8 [12] up to 14 weeks [10,12]. …”

Section: Discussionmentioning

confidence: 99%

“…Several dietary studies have used this model, including the administration of olive or fish oil and different seed extracts or oils, derived from sunflower seeds, peanuts, flaxseeds or hazelnuts [7-10]. An edible nut, consumed either alone or as an ingredient in traditional recipes, is the pistachio nut from the tree Pistacia vera , which belongs to the Anacardiaceae family and is distributed in central and southeastern Greece, as well as other Mediterranean and Middle East countries.…”

Section: Introductionmentioning

confidence: 99%

Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: an experimental study

et al. 2010

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BackgroundLipid-enriched diets and oxidative stress are risk factors for the development of atherosclerosis. The effects of the methanolic (ME) and cyclohexane (CHE) extracts of the Pistacia vera nut, often included in the Mediterranean diet, were studied in the rabbit model of atherosclerosis.Methods and resultsTwenty-four New Zealand White rabbits received atherogenic diet (Control Group), supplemented with ME (Group ME) or CHE (Group CHE) for 3 months. Previously, a GC-MS and a UHPLC LC-DAD-ESI(-)-HRMS/MS method were developed to investigate the extracts' chemical profiles. Blood samples at baseline and monthly determined lipid profile, lipid peroxidation and liver function. The aorta, myocardium and liver were examined histologically at 3 months.Groups ME and CHE had significantly higher HDL- and non-significantly lower LDL-cholesterol median % changes from baseline than the Control Group. Triacylglycerol was significantly higher in Group CHE vs. Control. MDA values were significantly lower in Group ME vs. Control and CHE. ALT and AST were significantly higher in Group CHE vs. Control. γ-GT was lower in Group ME vs. Control. Aortic intimal thickness was significantly less in Groups ME and CHE vs. Control; Group ME atherosclerotic lesions were significantly less extensive vs. Groups Control and CHE. Only Group CHE had significant liver fatty infiltration.ConclusionsDuring short-term administration concomitantly with atherogenic diet, both P. vera extracts were beneficial on HDL-, LDL-cholesterol and aortic intimal thickness. The ME additionally presented an antioxidant effect and significant decrease of aortic surface lesions. These results indicate that P. vera dietary inclusion, in particular its ME, is potentially beneficial in atherosclerosis management.

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Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet

Cited by 28 publications

References 36 publications

Health benefits of nuts: potential role of antioxidants

Health benefits of nuts: potential role of antioxidants

Antioxidant activity and phenolic content of fresh and dry nuts with or without the seed coat

Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: an experimental study

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