HbA1c levels are associated with severity of hypoxemia and not with apnea hypopnea index in patients with type 2 diabetes: Results from a cross‐sectional study

Abstract

The presence of sleep apnea is associated with poorer glycemic control in patients with T2D. In patients with sleep apnea and T2D, greater levels of oxygen desaturation are associated with poorer glycemic control.

Response to Kawada: Untreated sleep apnea syndrome and glycemic control in patients with type 2 diabetes

“…After adjustment for age, gender, diabetes duration, diabetes treatment, and body mass index, HbA1c was associated with mean and lowest O 2 saturation during sleep (β = −0.23 [ P = 0.03] and β = −0.24 [ P = 0.007], respectively). Further adjustment for waist circumference showed that HbA1c was independently associated only with the lowest O 2 saturation during sleep (β = −0.21; P = 0.05) . We did not observe any association between the apnea–hypopnea index and HbA1c …”

“…Further adjustment for waist circumference showed that HbA1c was independently associated only with the lowest O 2 saturation during sleep (β = −0.21; P = 0.05) . We did not observe any association between the apnea–hypopnea index and HbA1c …”

“…In our study enrolling 100 consecutive patients with type 2 diabetes (T2D), 64 had sleep apnea syndrome (SAS; SAS prevalence 64%), as assessed by a portable sleep diagnostic device (ApneaLink; ResMed, Poway, CA, USA), and we showed that patients with SAS had poorer diabetes control than those without SAS (HbA1c 8.4% vs 7.6%, respectively P = 0.04) . After adjustment for age, gender, diabetes duration, diabetes treatment, and body mass index, HbA1c was associated with mean and lowest O 2 saturation during sleep (β = −0.23 [ P = 0.03] and β = −0.24 [ P = 0.007], respectively).…”

“…To add to this, sleep duration and sleep quality may also have affected the glycemic control of the patients enrolled in our study. We acknowledged these and other limitations in our paper . A larger number of patients and collection of data on other potentially cofounding variables would have increased the generalizability of our analysis.…”

Untreated sleep apnea syndrome and glycemic control in patients with type 2 diabetes

“…Rusu et al 1 evaluated the relationship between untreated sleep apnea syndrome (SAS) and glycemic control in patients with type 2 diabetes (T2D). Among 100 patients with T2D, 64 patients had untreated SAS.…”