HCC advances in diagnosis and prognosis: Digital and Imaging

Abstract

Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide. Understanding of the pathogenesis of HCC has significantly improved in the past few years due to advances in genetics, molecular biology and pathology. Several subtypes have been identified with different backgrounds and outcomes, leading to possible changes in disease management and challenging the role of imaging. Indeed, despite its pivotal role in the diagnostic workup, prognosis, and the decision‐making process in patients with HCC, these recent developments are progressively redefining the role of imaging. First and most important, liver imaging is shifting from a purely qualitative to a quantitative paradigm, integrating quantitative imaging and radiomics in a digital era. Second, to improve patient management, imaging has gradually moved beyond tumor‐centered assessment to include a broader evaluation of the liver and its function. This review describes and discusses these advances in the imaging for the diagnosis and prognosis of HCC.

Oncogenic lncRNA BBOX1-AS1 promotes PHF8-mediated autophagy and elicits sorafenib resistance in hepatocellular carcinoma

“… 17 Most patients with HCC are diagnosed at an advanced stage and have a poor prognosis. 18 One significant factor for the adverse prognosis of advanced-stage HCC patients is acquired drug resistance during treatment, and its underlying mechanism has not been clearly elucidated. 19 Recent studies indicate that some oncogenic ncRNAs are associated with acquired drug resistance.…”

Low APOA-1 Expression in Hepatocellular Carcinoma Patients Is Associated With DNA Methylation and Poor Overall Survival

“…As one of the leading causes of cancer-related deaths, HCC is a significant public health burden ( Sartoris et al, 2021 ). Therefore, it is of great importance to detect indicators for optimizing early diagnosis and improving the prognosis of HCC ( Mustafa et al, 2013 ).…”

ALKBH5-mediated m6A modification of lincRNA LINC02551 enhances the stability of DDX24 to promote hepatocellular carcinoma growth and metastasis

“…Hepatocellular carcinoma (HCC) is one of the most common cancer and the third leading cause of cancer-related deaths worldwide [ 1 ]. The high mortality rate results from late presentation at an advanced stage, a high incidence of tumor metastasis, and tumor recurrence after surgical resection [ 2 ]. Although significant progress has been achieved, very few approaches can be utilized in the clinic to prevent the recurrence and metastasis of HCC [ 3 ].…”