2020
DOI: 10.3389/fcell.2020.605609
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HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation

Abstract: Odontoblast differentiation is an important process during tooth development in which pre-odontoblasts undergo elongation, polarization, and finally become mature secretory odontoblasts. Many factors have been found to regulate the process, and our previous studies demonstrated that autophagy plays an important role in tooth development and promotes odontoblastic differentiation in an inflammatory environment. However, it remains unclear how autophagy is modulated during odontoblast differentiation. In this st… Show more

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Cited by 10 publications
(3 citation statements)
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“…As described previously, HDAC6 can also function as a ubiquitin-binding protein to participate in aggresome formation ( 22 ). Additionally, HDAC6 can also mediate the acetylation of cortactin and microtubules to regulate autophagy via autophagosome-lysosome fusion and autophagosome transportation ( 23 , 86 , 156 ). Furthermore, HDAC6 interacts with p62 to regulate autophagy via various mechanisms ( 23 , 91 , 104 , 107 ).…”
Section: Discussionmentioning
confidence: 99%
“…As described previously, HDAC6 can also function as a ubiquitin-binding protein to participate in aggresome formation ( 22 ). Additionally, HDAC6 can also mediate the acetylation of cortactin and microtubules to regulate autophagy via autophagosome-lysosome fusion and autophagosome transportation ( 23 , 86 , 156 ). Furthermore, HDAC6 interacts with p62 to regulate autophagy via various mechanisms ( 23 , 91 , 104 , 107 ).…”
Section: Discussionmentioning
confidence: 99%
“…Among all HDAC enzymes, HDAC6 is increasingly emerging as a pivotal player in autophagy since it has been associated with the modulation of different pathways related to this biological process ( Figure 1 ) [ 76 ]. HDAC6 works in cooperation with the ubiquitin–proteasome system (UPS), favoring the processing of misfolded proteins [ 77 ].…”
Section: Role Of Hdac6 In Autophagic Processesmentioning
confidence: 99%
“…HDAC6 regulates the fusion of autophagosomes and lysosome during odontoblast differentiation. Decreased autophagy results in downregulation of odontoblastic differentiation capacity (75).…”
Section: Epigeneticsmentioning
confidence: 99%